{"id":6872,"date":"2026-04-27T01:40:52","date_gmt":"2026-04-26T16:40:52","guid":{"rendered":"https:\/\/www.takeuchi-iin.jp\/blog\/?p=6872"},"modified":"2026-04-27T02:05:22","modified_gmt":"2026-04-26T17:05:22","slug":"ages-anti-glycation-practical-guide-2026","status":"publish","type":"post","link":"https:\/\/www.takeuchi-iin.jp\/blog\/ages-anti-glycation-practical-guide-2026\/","title":{"rendered":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7cd6\u5316\uff09\u5bfe\u7b56\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9\uff5c\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u30fb\u85ac\u5264\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8001\u5316\u3068\u5408\u4f75\u75c7\u3092\u9632\u3050\u3010\u7530\u5712\u8abf\u5e03\u3011"},"content":{"rendered":"

\u7686\u3055\u307e\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u306e\u4e94\u85e4\u826f\u5c06\u3067\u3059\u3002<\/p>\n

\u524d\u56de\u306e\u30d6\u30ed\u30b0\u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185\u300d<\/strong><\/a>\u3067\u306f\u3001AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u304c\u52d5\u8108\u786c\u5316\u30fb\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u30fb\u8a8d\u77e5\u75c7\u30fb\u9aa8\u7c97\u9b06\u75c7\u30fb\u3046\u3064\u75c5\u30fb\u30d5\u30ec\u30a4\u30eb\u306a\u3069\u591a\u5f69\u306a\u75be\u60a3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u304a\u4f1d\u3048\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u300c\u3067\u306f\u3001\u3059\u3067\u306b\u4f53\u5185\u306b\u84c4\u7a4d\u3057\u59cb\u3081\u305fAGEs\u3092\u3069\u3046\u6e1b\u3089\u305b\u3070\u3088\u3044\u306e\u304b\uff1f\u300d\u300c\u65e5\u5e38\u751f\u6d3b\u3067\u4f55\u304b\u3089\u53d6\u308a\u7d44\u3080\u3079\u304d\u304b\uff1f\u300d\u2500\u2500\u4eca\u56de\u306f\u305d\u306e\u5b9f\u8df5\u7de8<\/strong>\u3068\u3057\u3066\u3001\u6700\u65b0\u306e\u533b\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u5916\u56e0\u6027AGEs\u3092\u6e1b\u3089\u3059\u98df\u4e8b\u3068\u8abf\u7406\u6cd5<\/strong>\u3001\u98df\u5f8c\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/strong>\u3001\u305d\u3057\u3066\u8fd1\u5e74\u6025\u901f\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528<\/strong>\u307e\u3067\u3001\u7530\u5712\u8abf\u5e03\u306e\u5f53\u9662\u3067\u5b9f\u969b\u306b\u304a\u4f1d\u3048\u3057\u3066\u3044\u308b\u5bfe\u7b56\u3092\u4f53\u7cfb\u7684\u306b\u89e3\u8aac\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n

\n

\u3053\u306e\u8a18\u4e8b\u306e\u30dd\u30a4\u30f3\u30c8<\/p>\n

AGEs\u306f \u300c\u5185\u56e0\u6027\uff08\u9ad8\u8840\u7cd6\u7531\u6765\uff09\u300d<\/strong> \u3068 \u300c\u5916\u56e0\u6027\uff08\u98df\u4e8b\u30fb\u55ab\u7159\u7531\u6765\uff09\u300d<\/strong> \u306e2\u7d4c\u8def\u3067\u84c4\u7a4d\u3057\u3001\u4e21\u65b9\u3078\u306e\u5bfe\u7b56\u304c\u5fc5\u8981\u3067\u3059\u3002\u98df\u4e8bAGEs\u306e\u524a\u6e1b\u3001\u98df\u5f8c\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3001\u9069\u5ea6\u306a\u904b\u52d5\u30fb\u7761\u7720\u30fb\u7981\u7159\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u306b\u52a0\u3048\u3001\u8fd1\u5e74\u306f\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3084SGLT2\u963b\u5bb3\u85ac\u3068\u3044\u3063\u305f\u7cd6\u5c3f\u75c5\u85ac\u304cAGE-RAGE\u8ef8\u3092\u6291\u5236\u3059\u308b<\/strong>\u3053\u3068\u304c\u57fa\u790e\u30fb\u81e8\u5e8a\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u9662\u3067\u306f\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\uff08\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff1aSAF\uff09\u3092\u7528\u3044\u3066\u3001\u751f\u6d3b\u7fd2\u6163\u30fb\u85ac\u7269\u7642\u6cd5\u306e\u52b9\u679c\u3092\u300c\u898b\u3048\u308b\u5316\u300d\u3057\u306a\u304c\u3089\u500b\u5225\u5316\u5bfe\u7b56\u3092\u9032\u3081\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n
\n1<\/text><\/svg>\n<\/td>\n\n

AGEs\u5bfe\u7b56\u306e\u5168\u4f53\u50cf \u2015 \u300c3\u3064\u306e\u8ef8\u300d\u3067\u8003\u3048\u308b<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

AGEs\u5bfe\u7b56\u306f\u3001\u5927\u304d\u304f3\u3064\u306e\u8ef8\u306b\u6574\u7406\u3057\u3066\u8003\u3048\u308b\u3068\u5206\u304b\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u30893\u3064\u306f\u4e92\u3044\u306b\u72ec\u7acb\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u305f\u3068\u3048\u3070\u98df\u5f8c\u306e\u904b\u52d5\u306f\u98df\u4e8b\u306e\u8840\u7cd6\u4e0a\u6607\u3092\u6291\u3048\u3001\u904b\u52d5\u306e\u7d99\u7d9a\u306f\u5185\u81d3\u8102\u80aa\u3092\u6e1b\u3089\u3057\u3066\u5185\u56e0\u6027AGEs\u3092\u6291\u5236\u3059\u308b\u306a\u3069\u3001\u76f8\u4e57\u52b9\u679c\u3092\u751f\u307f\u307e\u3059\u3002<\/p>\n\n\n\n\n\n
\u8ef8<\/th>\n\u5bfe\u8c61<\/th>\n\u4e3b\u306a\u5bfe\u7b56<\/th>\n<\/tr>\n
\u2460<\/td>\n\u5916\u56e0\u6027AGEs\u306e\u524a\u6e1b<\/strong>
\u98df\u54c1\u30fb\u55ab\u7159\u304b\u3089\u306e\u6442\u53d6\u3092\u6e1b\u3089\u3059<\/td>\n		\u8abf\u7406\u6cd5\u306e\u898b\u76f4\u3057\uff08\u713c\u304f\u30fb\u63da\u3052\u308b\u2192\u716e\u308b\u30fb\u84b8\u3059\uff09
\u9ad8AGE\u98df\u54c1\u306e\u983b\u5ea6\u3092\u4e0b\u3052\u308b
\u9178\u6027\u30de\u30ea\u30cd\uff08\u30ec\u30e2\u30f3\u30fb\u9162\uff09\u306e\u6d3b\u7528
\u7981\u7159<\/td>\n<\/tr>\n
\u2461<\/td>\n\u5185\u56e0\u6027AGEs\u306e\u6291\u5236<\/strong>
\u4f53\u5185\u3067\u306e\u7cd6\u5316\u53cd\u5fdc\u3092\u9045\u3089\u305b\u308b<\/td>\n		\u98df\u5f8c\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u306e\u6291\u5236
\u98df\u7269\u7e4a\u7dad\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u4f4eGI\u98df\u54c1
\u98df\u5f8c10\u301c20\u5206\u306e\u6b69\u884c
\u6709\u9178\u7d20\u904b\u52d5\u30fb\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\u306e\u7d99\u7d9a
\u5341\u5206\u306a\u7761\u7720\u3068\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/td>\n<\/tr>\n
\u2462<\/td>\n\u85ac\u5264\u306b\u3088\u308b\u6297\u7cd6\u5316<\/strong>
\u7cd6\u5c3f\u75c5\u30fb\u5fc3\u8840\u7ba1\u75c5\u306e\u3042\u308b\u65b9<\/td>\n		\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306b\u3088\u308bAMPK\u6d3b\u6027\u5316\u30fbRAGE\/NF-\u03baB\u6291\u5236
SGLT2\u963b\u5bb3\u85ac\u306b\u3088\u308b\u8840\u4e2dAGE\uff08MG-H1\uff09\u4f4e\u4e0b
\u4e3b\u6cbb\u533b\u306b\u3088\u308b\u500b\u5225\u5316\u306e\u85ac\u5264\u9078\u629e<\/td>\n<\/tr>\n<\/table>\n
\n

\u6ce8\u610f\uff1a<\/strong>\u8ef8\u2462\uff08\u85ac\u5264\uff09\u306f\u7cd6\u5c3f\u75c5\u306a\u3069\u9069\u5fdc\u306e\u3042\u308b\u65b9\u306b\u51e6\u65b9\u3055\u308c\u308b\u533b\u7642\u884c\u70ba\u3067\u3042\u308a\u3001\u5065\u5eb7\u306a\u65b9\u306e\u300c\u6297\u8001\u5316\u76ee\u7684\u306e\u81ea\u5df1\u670d\u7528\u300d\u3092\u52e7\u3081\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7cd6\u5c3f\u75c5\u6cbb\u7642\u3068\u6297\u7cd6\u5316\u3092\u4e21\u7acb\u3055\u305b\u305f\u3044\u65b9\u306f\u3001\u5f53\u9662\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda<\/strong><\/a>\u8a18\u4e8b\u3082\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/div>\n\n\n
\n2<\/text><\/svg>\n<\/td>\n\n

\u5916\u56e0\u6027AGEs\u3092\u6e1b\u3089\u3059 \u2015 \u8abf\u7406\u6cd5\u304c\u6700\u5927\u306e\u30dd\u30a4\u30f3\u30c8<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u4f53\u5185\u306eAGEs\u306e\u4e00\u90e8\u306f\u3001\u6bce\u65e5\u306e\u98df\u4e8b\u304b\u3089\u53d6\u308a\u8fbc\u307e\u308c\u308b\u300c\u5916\u56e0\u6027AGEs\u300d\u304c\u7531\u6765\u3067\u3059\u3002\u30de\u30a6\u30f3\u30c8\u30b5\u30a4\u30ca\u30a4\u533b\u79d1\u5927\u5b66\u306eUribarri\u535a\u58eb\u3089\u306f549\u7a2e\u985e\u306e\u98df\u54c1\u3092\u6e2c\u5b9a\u3057\u3001\u300c\u98df\u54c1\u4e2d\u306eAGE\u542b\u91cf\u306f\u98df\u6750\u305d\u306e\u3082\u306e\u3088\u308a\u3082\u3001\u8abf\u7406\u6cd5\u30fb\u6e29\u5ea6\u30fb\u6c34\u5206\u306e\u6709\u7121<\/strong>\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3059\u308b\u300d\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08Uribarri J et al. J Am Diet Assoc<\/em>. 2010\uff09\u3002<\/p>\n\n\n
\n2-1<\/text><\/svg>\n<\/td>\n\n

\u540c\u3058\u98df\u6750\u3067\u3082\u8abf\u7406\u6cd5\u3067AGEs\u306f10\u301c100\u500d\u5909\u308f\u308b<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

Uribarri\u3089\u306e\u98df\u54c1\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff082010\uff09\u306b\u3088\u308c\u3070\u3001\u98df\u54c1AGEs\uff08CML\u3067\u8a55\u4fa1\uff09\u306f\u4e7e\u71b1\u8abf\u7406\uff08\u63da\u3052\u308b\u30fb\u30aa\u30fc\u30d6\u30f3\u713c\u304d\u30fb\u76f4\u706b\u713c\u304d\uff09\u3067\u3082\u3063\u3068\u3082\u5897\u52a0<\/strong>\u3057\u3001\u672a\u52a0\u71b1\u72b6\u614b\u3068\u6bd4\u8f03\u3057\u306610\u301c100\u500d\u306b\u9054\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u540c\u3058\u9d8f\u8089\u3067\u3082\u3001\u63da\u3052\u308b\u30fb\u76f4\u706b\u713c\u304d\u3067\u8abf\u7406\u3057\u305f\u3082\u306e\u3068\u3001\u716e\u308b\u30fb\u84b8\u3059\u3067\u8abf\u7406\u3057\u305f\u3082\u306e\u3067\u306f\u3001AGE\u542b\u91cf\u304c\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n\n\n
\u8abf\u7406\u6cd5<\/th>\n\u6e29\u5ea6\u306e\u76ee\u5b89<\/th>\nAGEs\u751f\u6210\u50be\u5411<\/th>\n<\/tr>\n
\u8339\u3067\u308b\u30fb\u716e\u308b<\/td>\n100\u2103<\/td>\n⭕ \u6700\u3082\u4f4e\u3044<\/td>\n<\/tr>\n
\u84b8\u3059<\/td>\n100\u2103<\/td>\n⭕ \u4f4e\u3044<\/td>\n<\/tr>\n
\u6e6f\u305b\u3093\u30fb\u4f4e\u6e29\u8abf\u7406<\/td>\n60\u301c80\u2103<\/td>\n⭕ \u4f4e\u3044<\/td>\n<\/tr>\n
\u30d5\u30e9\u30a4\u30d1\u30f3\u713c\u304d<\/td>\n150\u301c200\u2103<\/td>\n\u25b3 \u3084\u3084\u9ad8\u3044<\/td>\n<\/tr>\n
\u30b0\u30ea\u30eb\u30fb\u76f4\u706b\u713c\u304d<\/td>\n200\u301c250\u2103<\/td>\n\u25b3 \u9ad8\u3044<\/td>\n<\/tr>\n
\u63da\u3052\u308b<\/td>\n170\u301c200\u2103<\/td>\n\u2715 \u975e\u5e38\u306b\u9ad8\u3044<\/td>\n<\/tr>\n
\u30aa\u30fc\u30d6\u30f3\u713c\u304d\uff08\u30ed\u30fc\u30b9\u30c8\uff09<\/td>\n200\u2103\u4ee5\u4e0a<\/td>\n\u2715 \u6700\u3082\u9ad8\u3044<\/td>\n<\/tr>\n<\/table>\n

\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u300c\u6c34\u5206\u306e\u6709\u7121\u300d\u3068\u300c\u6e29\u5ea6\u300d<\/strong>\u3067\u3059\u3002\u6c34\u3092\u4ecb\u3057\u305f\u52a0\u71b1\uff08\u8339\u3067\u308b\u30fb\u84b8\u3059\u30fb\u716e\u308b\uff09\u306f\u6700\u9ad8\u3067\u3082100\u2103\u306b\u3057\u304b\u306a\u3089\u305a\u3001AGEs\u751f\u6210\u306f\u7a4f\u3084\u304b\u3067\u3059\u3002\u4e00\u65b9\u3001\u6cb9\u3084\u76f4\u706b\u306b\u3088\u308b\u4e7e\u71b1\u8abf\u7406\u306f150\u301c250\u2103\u306b\u9054\u3057\u3001\u30e1\u30a4\u30e9\u30fc\u30c9\u53cd\u5fdc\u304c\u7206\u767a\u7684\u306b\u9032\u884c\u3057\u307e\u3059\u3002<\/p>\n\n\n
\n2-2<\/text><\/svg>\n<\/td>\n\n

\u9178\u6027\u30de\u30ea\u30cd\uff08\u30ec\u30e2\u30f3\u30fb\u9162\uff09\u3067AGEs\u309220\u301c30%\u30ab\u30c3\u30c8<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u8abf\u7406\u524d\u306b\u8089\u3092\u30ec\u30e2\u30f3\u6c41\u30fb\u9162\u30fb\u30c8\u30de\u30c8\u306a\u3069\u306e\u9178\u6027\u98df\u6750<\/strong>\u3067\u30de\u30ea\u30cd\u3059\u308b\u3068\u3001\u52a0\u71b1\u6642\u306eAGE\u751f\u6210\u3092\u6291\u3048\u308b\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Uribarri J et al. J Am Diet Assoc<\/em>. 2010\uff09\u3002\u9178\u6027\u6761\u4ef6\u4e0b\u3067\u306f\u30e1\u30a4\u30e9\u30fc\u30c9\u53cd\u5fdc\u306e\u9032\u884c\u304c\u9045\u304f\u306a\u308b\u305f\u3081\u3067\u3059\u3002\u540c\u3058\u8abf\u7406\u6cd5\u3067\u3082\u3001\u30de\u30ea\u30cd\u306e\u4e00\u624b\u9593\u3067\u98df\u4e8bAGEs\u3092\u5927\u304d\u304f\u6e1b\u3089\u305b\u308b\u3001\u7c21\u5358\u3067\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u3067\u3059\u3002<\/p>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a\u30de\u30ea\u30cd\u306b\u3088\u308bAGE\u6291\u5236<\/p>\n

Uribarri\u3089\u306f\u3001\u8089\u3092\u30ec\u30e2\u30f3\u6c41\u307e\u305f\u306f\u9162\u3067\u30de\u30ea\u30cd\u3059\u308b\u3068\u3001\u540c\u6761\u4ef6\u3067\u8abf\u7406\u3057\u305f\u975e\u30de\u30ea\u30cd\u8089\u3068\u6bd4\u8f03\u3057\u3066AGE\u542b\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08Uribarri J et al. J Am Diet Assoc<\/em>. 2010\uff09\u3002\u5bb6\u5ead\u3067\u3082\u3001\u5510\u63da\u3052\u3092\u4f5c\u308b\u524d\u306b\u4e0b\u5473\u3068\u3057\u3066\u9162\u3084\u30ec\u30e2\u30f3\u3092\u52a0\u3048\u308b\u3001\u30b9\u30c6\u30fc\u30ad\u306e\u524d\u306b\u30d0\u30eb\u30b5\u30df\u30b3\u9162\u3067\u6f2c\u3051\u8fbc\u3080\u3068\u3044\u3063\u305f\u5de5\u592b\u3067\u5b9f\u8df5\u3067\u304d\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n
\n2-3<\/text><\/svg>\n<\/td>\n\n

\u9ad8AGE\u98df\u54c1 vs \u4f4eAGE\u98df\u54c1<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u98df\u54c1\u7531\u6765AGEs\u306e\u4e00\u822c\u7684\u306a\u50be\u5411\u3068\u3057\u3066\u3001Uribarri\u3089\u306e\u5927\u898f\u6a21\u98df\u54c1\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff082010\uff09\u3067\u306f\u4ee5\u4e0b\u306e\u50be\u5411\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
\u9ad8AGE\u98df\u54c1\uff08\u8981\u6ce8\u610f\uff09<\/th>\n\u4f4eAGE\u98df\u54c1\uff08\u63a8\u5968\uff09<\/th>\n<\/tr>\n
\n\u30fb\u9ad8\u6e29\u8abf\u7406\u3057\u305f\u8089\u985e\uff08\u63da\u3052\u7269\u30fb\u30b0\u30ea\u30eb\uff09
\n\u30fb\u52a0\u5de5\u8089\uff08\u30d9\u30fc\u30b3\u30f3\u30fb\u30bd\u30fc\u30bb\u30fc\u30b8\u30fb\u30cf\u30e0\uff09
\n\u30fb\u9ad8\u8102\u80aa\u306e\u30c1\u30fc\u30ba\uff08\u30d1\u30eb\u30e1\u30b6\u30f3\u7b49\uff09
\n\u30fb\u30b9\u30ca\u30c3\u30af\u83d3\u5b50\u30fb\u30af\u30e9\u30c3\u30ab\u30fc\u30fb\u30dd\u30c6\u30c8\u30c1\u30c3\u30d7\u30b9
\n\u30fb\u30af\u30c3\u30ad\u30fc\u30fb\u30d3\u30b9\u30b1\u30c3\u30c8\u30fb\u713c\u304d\u83d3\u5b50
\n\u30fb\u30c8\u30fc\u30b9\u30c8\u30fb\u30d1\u30f3\u306e\u7126\u3052\u76ee
\n\u30fb\u63da\u3052\u7269\u5168\u822c\uff08\u30d5\u30e9\u30a4\u30c9\u30dd\u30c6\u30c8\u30fb\u5929\u3077\u3089\uff09\n<\/td>\n		\n\u30fb\u91ce\u83dc\uff08\u751f\u30fb\u84b8\u3057\u30fb\u716e\uff09
\n\u30fb\u679c\u7269\uff08\u751f\uff09
\n\u30fb\u8c46\u985e\u30fb\u5927\u8c46\u88fd\u54c1\uff08\u8c46\u8150\u30fb\u7d0d\u8c46\uff09
\n\u30fb\u5168\u7c92\u7a40\u7269\uff08\u7384\u7c73\u30fb\u96d1\u7a40\uff09
\n\u30fb\u4f4e\u8102\u80aa\u306e\u4e73\u88fd\u54c1\u30fb\u30e8\u30fc\u30b0\u30eb\u30c8
\n\u30fb\u716e\u9b5a\u30fb\u84b8\u3057\u9b5a
\n\u30fb\u6c34\u716e\u306e\u9d8f\u3080\u306d\u8089\u30fb\u3057\u3083\u3076\u3057\u3083\u3076\n<\/td>\n<\/tr>\n<\/table>\n

\u305f\u3060\u3057\u3001\u3053\u308c\u306f\u300c\u8089\u3084\u4e73\u88fd\u54c1\u3092\u5b8c\u5168\u306b\u907f\u3051\u308b\u3079\u304d\u300d\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u540c\u3058\u98df\u6750\u3067\u3082\u8abf\u7406\u6cd5\u3092\u5909\u3048\u308b\u3053\u3068\u304c\u5148\u6c7a<\/strong>\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u300c\u713c\u304d\u9ce5\u300d\u3092\u300c\u6c34\u708a\u304d\u300d\u3084\u300c\u9d8f\u30cf\u30e0\uff08\u4f4e\u6e29\u8abf\u7406\uff09\u300d\u306b\u5909\u3048\u308b\u3060\u3051\u3067\u3001\u6804\u990a\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3055\u305a\u306bAGE\u6442\u53d6\u91cf\u3092\u5927\u304d\u304f\u6e1b\u3089\u305b\u307e\u3059\u3002<\/p>\n\n\n
\n3<\/text><\/svg>\n<\/td>\n\n

\u98df\u4e8bAGEs\u524a\u6e1b\u306e\u81e8\u5e8a\u52b9\u679c \u2015 \u4f53\u91cd\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u30fb\u708e\u75c7\u304c\u6539\u5584<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u98df\u4e8bAGEs\u306e\u524a\u6e1b\u306f\u3001\u5358\u306a\u308b\u300c\u4e88\u9632\u300d\u3067\u306f\u306a\u304f\u3001\u3059\u3067\u306b\u4ee3\u8b1d\u7570\u5e38\u304c\u3042\u308b\u65b9\u306e\u81e8\u5e8a\u6307\u6a19\u3092\u6539\u5584\u3059\u308b<\/strong>\u3053\u3068\u304c\u8907\u6570\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\u2460\uff1a\u30e1\u30bf\u30dc\u60a3\u8005\u3067\u306eAGE\u5236\u9650RCT\uff08Vlassara H et al. Diabetologia<\/em>. 2016\uff09<\/p>\n

\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3092\u6709\u3059\u308b\u80a5\u6e80\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u3001AGE\u5236\u9650\u98df\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u30fb\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u98df\u4e8bAGEs\u306e\u524a\u6e1b\u304c\u3001\u30e1\u30bf\u30dc\u306e\u75c5\u614b\u305d\u306e\u3082\u306e\u306b\u4ecb\u5165\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u91cd\u8981\u306a\u8a66\u9a13\u3067\u3059\u3002<\/p>\n<\/div>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\u2461\uff1a2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306eAGE\u5236\u9650\uff08Uribarri J et al. Diabetes Care<\/em>. 2011\uff09<\/p>\n

2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8a66\u9a13\u3067\u3001AGE\u5236\u9650\u98df\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u3001\u6297\u708e\u75c7\u6027\u306eAGE\u53d7\u5bb9\u4f53\uff08AGER1\uff09\u3068\u9577\u5bff\u95a2\u9023\u5206\u5b50SIRT1\u306e\u767a\u73fe\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u300c\u98df\u4e8bAGE\u524a\u6e1b \u2192 \u7d30\u80de\u30ec\u30d9\u30eb\u306e\u6297\u708e\u75c7\u30fb\u6297\u8001\u5316\u30b7\u30b0\u30ca\u30eb\u6539\u5584\u300d\u3068\u3044\u3046\u6a5f\u5e8f\u7684\u306a\u88cf\u4ed8\u3051\u304c\u5f97\u3089\u308c\u305f\u7814\u7a76\u3067\u3059\u3002<\/p>\n<\/div>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\u2462\uff1a\u690d\u7269\u6027\u98df\u306b\u3088\u308b16\u9031RCT\uff08Kahleova H et al. Obes Sci Pract<\/em>. 2023\uff09<\/p>\n

\u904e\u4f53\u91cd\u306e\u6210\u4eba244\u540d\u3092\u5bfe\u8c61\u306b\u3001\u4f4e\u8102\u80aa\u306e\u690d\u7269\u6027\u98df\u309216\u9031\u9593\u7d9a\u3051\u305fRCT\u3067\u306f\u3001\u98df\u4e8bAGEs\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3001\u305d\u306e\u6e1b\u5c11\u5e45\u306f\u4f53\u91cd\u6e1b\u5c11\u30fb\u4f53\u8102\u80aa\u6e1b\u5c11\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u6539\u5584<\/strong>\u3068\u6709\u610f\u306b\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u6442\u53d6\u91cf\u3067\u88dc\u6b63\u5f8c\u3082\u52b9\u679c\u304c\u6b8b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u300c\u30ab\u30ed\u30ea\u30fc\u3092\u6e1b\u3089\u3057\u305f\u52b9\u679c\u300d\u3060\u3051\u3067\u306f\u306a\u304f\u300cAGEs\u3092\u6e1b\u3089\u3057\u305f\u52b9\u679c\u300d\u304c\u72ec\u7acb\u3057\u3066\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\u3053\u308c\u3089\u306f\u3001\u30e1\u30bf\u30dc\u3084\u7cd6\u5c3f\u75c5\u306e\u9032\u884c\u304c\u6c17\u306b\u306a\u308b\u65b9\u306b\u3068\u3063\u3066\u3001\u98df\u4e8bAGEs\u306e\u524a\u6e1b\u305d\u306e\u3082\u306e\u304c\u6cbb\u7642\u7684\u4fa1\u5024\u3092\u6301\u3064\u4ecb\u5165<\/strong>\u306b\u306a\u308a\u3046\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\u306e\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\uff5c2024\u5e74\u65b0\u57fa\u6e96\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3092\u5fb9\u5e95\u89e3\u8aac\u300d<\/strong><\/a>\u3082\u3042\u308f\u305b\u3066\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n
\n4<\/text><\/svg>\n<\/td>\n\n

\u98df\u5f8c\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u306e\u6291\u5236 \u2015 \u5185\u56e0\u6027AGEs\u3092\u6e1b\u3089\u3059\u6700\u91cd\u8981\u30dd\u30a4\u30f3\u30c8<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u4f53\u5185\u306b\u84c4\u7a4d\u3059\u308bAGEs\u306e\u4e3b\u8981\u4f9b\u7d66\u6e90\u306f\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u4e0a\u6607\u306b\u4f34\u3046\u5185\u56e0\u6027AGE\u751f\u6210<\/strong>\u3067\u3059\u3002HbA1c\uff08\u904e\u53bb1\u301c2\u304b\u6708\u306e\u5e73\u5747\u8840\u7cd6\uff09\u304c\u540c\u3058\u3067\u3082\u3001\u98df\u5f8c\u306b180mg\/dL\u3092\u8d85\u3048\u308b\u6642\u9593\uff08Time Above Range\uff09\u304c\u9577\u3044\u4eba\u307b\u3069\u3001\u7d44\u7e54\u306eAGE\u5316\u304c\u9032\u307f\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n
\n4-1<\/text><\/svg>\n<\/td>\n\n

\u98df\u7269\u7e4a\u7dad\u30d5\u30a1\u30fc\u30b9\u30c8\u3067\u98df\u5f8c\u8840\u7cd6\u3092\u5e73\u5766\u306b<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u540c\u3058\u30ab\u30ed\u30ea\u30fc\u30fb\u540c\u3058\u6804\u990a\u7d20\u3067\u3082\u3001\u98df\u3079\u308b\u9806\u756a<\/strong>\u3092\u5909\u3048\u308b\u3053\u3068\u3067\u98df\u5f8c\u8840\u7cd6\u306e\u4e0a\u6607\u30ab\u30fc\u30d6\u306f\u5927\u304d\u304f\u5909\u308f\u308a\u307e\u3059\u3002\u5f53\u9662\u3067\u306f\u4ee5\u4e0b\u306e\u9806\u756a\u3092\u304a\u52e7\u3081\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n\n\n
\u9806\u756a<\/th>\n\u98df\u54c1\u4f8b<\/th>\n\u671f\u5f85\u3055\u308c\u308b\u52b9\u679c<\/th>\n<\/tr>\n
1. \u98df\u7269\u7e4a\u7dad<\/td>\n\u91ce\u83dc\u30fb\u6d77\u85fb\u30fb\u304d\u306e\u3053\u30fb\u5927\u8c46<\/td>\n\u7cd6\u306e\u5438\u53ce\u901f\u5ea6\u3092\u7de9\u3084\u304b\u306b\u3059\u308b<\/td>\n<\/tr>\n
2. \u30bf\u30f3\u30d1\u30af\u8cea\u30fb\u8102\u8cea<\/td>\n\u8089\u30fb\u9b5a\u30fb\u5375\u30fb\u8c46\u8150<\/td>\n\u6e80\u8179\u611f\u3092\u51fa\u3057\u3001\u7cd6\u8cea\u6442\u53d6\u91cf\u3092\u6291\u3048\u308b<\/td>\n<\/tr>\n
3. \u70ad\u6c34\u5316\u7269<\/td>\n\u3054\u306f\u3093\u30fb\u30d1\u30f3\u30fb\u9eba<\/td>\n\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u306e\u30d4\u30fc\u30af\u3092\u6291\u3048\u308b<\/td>\n<\/tr>\n<\/table>\n

\u3042\u308f\u305b\u3066\u3001\u3086\u3063\u304f\u308a\u3088\u304f\u565b\u3093\u3067\u98df\u3079\u308b<\/strong>\u3053\u3068\u30011\u98df\u309220\u5206\u4ee5\u4e0a\u304b\u3051\u3066\u98df\u3079\u308b<\/strong>\u3053\u3068\u3082\u3001\u8840\u7cd6\u4e0a\u6607\u30ab\u30fc\u30d6\u3092\u5e73\u5766\u5316\u3055\u305b\u308b\u5358\u7d14\u3067\u5f37\u529b\u306a\u624b\u6bb5\u3067\u3059\u3002<\/p>\n\n\n
\n4-2<\/text><\/svg>\n<\/td>\n\n

\u98df\u5f8c10\u301c20\u5206\u306e\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u98df\u5f8c\u306e\u8840\u7cd6\u5024\u306f\u3001\u98df\u4e8b\u958b\u59cb\u304b\u3089\u304a\u304a\u3080\u306d30\u301c60\u5206\u5f8c\u306b\u30d4\u30fc\u30af\u3092\u8fce\u3048\u307e\u3059\u3002\u3053\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u8eab\u4f53\u3092\u52d5\u304b\u3059\u3053\u3068\u3067\u3001\u9aa8\u683c\u7b4b\u304c\u7cd6\u3092\u53d6\u308a\u8fbc\u307f\u3001\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u306e\u30d4\u30fc\u30af\u3092\u6291\u3048\u308b<\/strong>\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u6fc0\u3057\u3044\u904b\u52d5\u3067\u3042\u308b\u5fc5\u8981\u306f\u306a\u304f\u3001\u5bb6\u4e8b\u30fb\u8cb7\u3044\u7269\u30fb\u8fd1\u6240\u306e\u6563\u6b69\u7a0b\u5ea6\u3067\u5341\u5206\u3067\u3059\u3002\u300c\u98df\u5f8c\u306b\u5ea7\u308a\u3053\u307e\u306a\u3044\u300d\u3092\u5408\u8a00\u8449\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n
\n4-3<\/text><\/svg>\n<\/td>\n\n

CGM\u306b\u3088\u308b\u300c\u898b\u3048\u308b\u5316\u300d \u2015 \u5f53\u9662\u306e\u7279\u9577<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u300c\u81ea\u5206\u306e\u8840\u7cd6\u5024\u304c\u3001\u3069\u306e\u98df\u4e8b\u3067\u3069\u308c\u3060\u3051\u4e0a\u304c\u3063\u3066\u3044\u308b\u306e\u304b\u300d\u3092\u5ba2\u89b3\u7684\u306b\u628a\u63e1\u3059\u308b\u6700\u3082\u6709\u529b\u306a\u65b9\u6cd5\u304c\u3001CGM\uff08\u6301\u7d9a\u8840\u7cd6\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff09<\/strong>\u3067\u3059\u3002FreeStyle\u30ea\u30d6\u30ec\u306a\u3069\u3092\u4e0a\u8155\u306b\u88c5\u7740\u3059\u308b\u3068\u300124\u6642\u9593\u306e\u8840\u7cd6\u5909\u52d5\u3092\u9023\u7d9a\u7684\u306b\u53ef\u8996\u5316\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u540c\u3058\u300c\u767d\u7c73\u300d\u3067\u3082\u3001\u3042\u308b\u4eba\u306f\u6025\u4e0a\u6607\u3059\u308b\u304c\u5225\u306e\u4eba\u306f\u7a4f\u3084\u304b\u3001\u307e\u305f\u300c\u30d1\u30f3\u300d\u3067\u4e0a\u304c\u308a\u3084\u3059\u3044\u304b\u300c\u854e\u9ea6\u300d\u3067\u4e0a\u304c\u308a\u3084\u3059\u3044\u304b\u306f\u500b\u4eba\u5dee\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u3001CGM\u3067\u521d\u3081\u3066\u898b\u3048\u3066\u304d\u307e\u3059\u3002\u300c\u81ea\u5206\u306b\u3068\u3063\u3066\u306e\u9ad8AGE\u98df\u300d\u3092\u7279\u5b9a\u3059\u308b\u500b\u5225\u5316\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002CGM\u306e\u5b9f\u969b\u306e\u6d3b\u7528\u306b\u3064\u3044\u3066\u306f\u3001\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda<\/strong><\/a>\u8a18\u4e8b\u306b\u8a73\u3057\u304f\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n
\n5<\/text><\/svg>\n<\/td>\n\n

\u904b\u52d5\u30fb\u7761\u7720\u30fb\u7981\u7159 \u2015 \u5185\u56e0\u6027AGEs\u3092\u6291\u3048\u308b3\u3064\u306e\u571f\u53f0<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n\n\n
\n5-1<\/text><\/svg>\n<\/td>\n\n

\u904b\u52d5\uff1a\u6709\u9178\u7d20\uff0b\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u306e\u4f75\u7528<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u904b\u52d5\u306f\u77ed\u671f\u7684\u306b\u306f\u98df\u5f8c\u8840\u7cd6\u3092\u4e0b\u3052\u3001\u9577\u671f\u7684\u306b\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u6539\u5584\u3057\u3001\u5185\u81d3\u8102\u80aa\u3092\u6e1b\u3089\u3059\u3053\u3068\u3067\u5185\u56e0\u6027AGEs\u751f\u6210\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u9031150\u5206\u4ee5\u4e0a\u306e\u4e2d\u5f37\u5ea6\u6709\u9178\u7d20\u904b\u52d5\uff08\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u30fb\u81ea\u8ee2\u8eca\uff09\u306b\u52a0\u3048\u3066\u3001\u90312\u56de\u7a0b\u5ea6\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\uff08\u8efd\u3044\u7b4b\u30c8\u30ec\uff09<\/strong>\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089\u3082\u6709\u5229\u3067\u3059\u3002AGEs\u3068\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u306e\u95a2\u9023\u306f\u3001Rotterdam Study\u306e\u30c7\u30fc\u30bf\u3067\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u65e2\u5b58\u306eAGEs\u7dcf\u8ad6\u8a18\u4e8b<\/strong><\/a>\u3092\u53c2\u7167\uff09\u3002<\/p>\n\n\n
\n5-2<\/text><\/svg>\n<\/td>\n\n

\u7761\u7720\uff1a6\u301c7\u6642\u9593\u4ee5\u4e0a\u3092\u78ba\u4fdd<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u7761\u7720\u4e0d\u8db3\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u3092\u6e1b\u3089\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u8840\u7cd6\u4e0a\u6607\u3068AGE\u84c4\u7a4d\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u82b1\u738b\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u4f1a\u306b\u3088\u308b\u65e5\u672c\u4eba\u7d041\u4e071,000\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8abf\u67fb\u3067\u3082\u3001\u7761\u7720\u4e0d\u8db3\u306f\u5e74\u9f62\u3068\u306f\u72ec\u7acb\u3057\u3066\u76ae\u819aAGEs\u84c4\u7a4d\u91cf\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5c31\u5bdd\u6642\u9593\u3092\u4e00\u5b9a\u306b\u4fdd\u3064\u30fb\u5c31\u5bdd\u524d\u306e\u30b9\u30de\u30db\u3092\u63a7\u3048\u308b\u30fb\u5bdd\u5ba4\u306e\u5149\u3068\u6e29\u5ea6\u3092\u6574\u3048\u308b<\/strong>\u3068\u3044\u3063\u305f\u57fa\u672c\u7684\u306a\u7761\u7720\u885b\u751f\u304c\u3001\u6297\u7cd6\u5316\u5bfe\u7b56\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n\n
\n5-3<\/text><\/svg>\n<\/td>\n\n

\u7981\u7159\uff1a\u5916\u56e0\u6027AGEs\u306e\u5927\u304d\u306a\u4f9b\u7d66\u6e90<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u30bf\u30d0\u30b3\u306e\u8449\u3092\u4e7e\u71e5\u30fb\u71c3\u713c\u3055\u305b\u308b\u904e\u7a0b\u3067\u751f\u3058\u308bAGEs\u306f\u3001\u80ba\u304b\u3089\u76f4\u63a5\u8840\u4e2d\u306b\u5438\u53ce\u3055\u308c\u307e\u3059\u3002\u55ab\u7159\u8005\u306f\u975e\u55ab\u7159\u8005\u3068\u6bd4\u8f03\u3057\u3066\u8840\u4e2d\u30fb\u76ae\u819a\u4e2d\u306eAGE\u6fc3\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u7981\u7159\u306f\u5916\u56e0\u6027AGEs\u524a\u6e1b\u7b56\u306e\u306a\u304b\u3067\u3082\u6700\u3082\u52b9\u679c\u304c\u5927\u304d\u3044\u3082\u306e\u306e\u3072\u3068\u3064<\/strong>\u3067\u3059\u3002\u5f53\u9662\u3067\u3082\u7981\u7159\u5916\u6765\u3067\u652f\u63f4\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n
\n6<\/text><\/svg>\n<\/td>\n\n

\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528 \u2015 \u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u7cd6\u5c3f\u75c5\u3092\u304a\u6301\u3061\u306e\u65b9\u306b\u3068\u3063\u3066\u3001\u7cd6\u5c3f\u75c5\u85ac\u305d\u306e\u3082\u306e\u304c\u6297\u7cd6\u5316\u306b\u8ca2\u732e\u3059\u308b<\/strong>\u53ef\u80fd\u6027\u304c\u3001\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u6b21\u3005\u3068\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u300c\u8840\u7cd6\u3092\u4e0b\u3052\u308b\u3053\u3068\u3067\u9593\u63a5\u7684\u306bAGEs\u3092\u6e1b\u3089\u3059\u300d\u3068\u3044\u3046\u5f93\u6765\u306e\u7406\u89e3\u3092\u8d85\u3048\u305f\u3001\u85ac\u5264\u306e\u591a\u9762\u7684\u52b9\u679c\uff08pleiotropic effects\uff09<\/strong>\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n
\n6-1<\/text><\/svg>\n<\/td>\n\n

\u30e1\u30c8\u30db\u30eb\u30df\u30f3 \u2015 AMPK\u6d3b\u6027\u5316\u3068RAGE\u6291\u5236<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u306e\u4e00\u3064\u3067\u3042\u308b\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306f\u3001AMPK\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u9175\u7d20\uff09\u3092\u6d3b\u6027\u5316<\/strong>\u3059\u308b\u3053\u3068\u3067\u3001AGE-RAGE\u30b7\u30b0\u30ca\u30eb\u3092\u4e0b\u6d41\u307e\u3067\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u57fa\u790e\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u6297AGE\u4f5c\u7528\uff08Han L et al. 2016, PMID 27761470\uff09<\/p>\n

\u30de\u30a6\u30b9\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u3001AGEs\u306fRAGE\u767a\u73fe\u3068NF-\u03baB\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1\u03b2\u3001IL-6\u3001TNF-\u03b1\uff09\u306e\u7523\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059\u304c\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u524d\u51e6\u7f6e\u306f\u3053\u308c\u3089\u3092\u3059\u3079\u3066\u6291\u5236\u3057\u3001\u6297\u708e\u75c7\u6027\u306eM2\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3078\u306e\u6975\u6027\u5316\u3092\u4fc3\u9032\u3057\u307e\u3057\u305f\u3002AMPK\u963b\u5bb3\u5264\u3092\u52a0\u3048\u308b\u3068\u3053\u306e\u52b9\u679c\u306f\u6e1b\u5f31\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u6297AGE\u708e\u75c7\u4f5c\u7528\u306fAMPK\u6d3b\u6027\u5316\u3092\u4ecb\u3059\u308b<\/strong>\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001Ishibashi Y\u3089\u306e\u7814\u7a76\uff08PMID 23225247, 2012\uff09\u3067\u306f\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304cAMPK\u7d4c\u8def\u3092\u4ecb\u3057\u3066RAGE\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6291\u5236\u3057\u3001AGE\u8a98\u5c0e\u6027\u306eVEGF\u767a\u73fe\u3068\u7d30\u80de\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002Schurman L\u3089\u306e\u7814\u7a76\uff08PMID 18273753\uff09\u3067\u306f\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u9aa8\u82bd\u7d30\u80de\u3092AGEs\u306e\u7d30\u80de\u6b7b\u4f5c\u7528\u304b\u3089\u4fdd\u8b77\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n

\u3053\u308c\u3089\u306e\u57fa\u790e\u7814\u7a76\u306f\u3001\u300c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u9032\u5c55\u3092\u6291\u3048\u308b\u80cc\u666f\u306b\u306f\u3001\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u306b\u52a0\u3048\u3066\u6297AGE\u4f5c\u7528\u304c\u3042\u308b<\/strong>\u300d\u3068\u3044\u3046\u89e3\u91c8\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n
\n6-2<\/text><\/svg>\n<\/td>\n\n

SGLT2\u963b\u5bb3\u85ac \u2015 \u8840\u4e2dAGE\uff08MG-H1\uff09\u306e\u6709\u610f\u306a\u4f4e\u4e0b<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

SGLT2\u963b\u5bb3\u85ac\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u30fb\u814e\u4e0d\u5168\u9032\u884c\u3092\u6291\u3048\u308b\u52b9\u679c\u304cEMPA-REG OUTCOME\u8a66\u9a13\u7b49\u3067\u793a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u5206\u5b50\u6a5f\u5e8f\u306e\u3072\u3068\u3064\u3068\u3057\u3066AGE-RAGE\u8ef8\u306e\u6291\u5236\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aSGLT2\u963b\u5bb3\u85ac\u306e\u30d2\u30c8\u3067\u306eAGE\u4f4e\u4e0b\u4f5c\u7528\uff08Tsuruta H, Ono J. 2024, PMID 38286421\uff09<\/p>\n

2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092SGLT2\u963b\u5bb3\u85ac\u7fa4\u3068DPP-4\u963b\u5bb3\u85ac\u7fa4\u306b\u5206\u3051\u30013\u304b\u6708\u5f8c\u306eAGE\uff08\u30e1\u30c1\u30eb\u30b0\u30ea\u30aa\u30ad\u30b5\u30fc\u30eb\u7531\u6765\u306eMG-H1\uff09\u3068\u8840\u7cd6\u95a2\u9023\u6307\u6a19\u3092\u6bd4\u8f03\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3067\u3059\u3002SGLT2\u963b\u5bb3\u85ac\u7fa4\u3067\u306fHbA1c\u3068\u8840\u4e2dMG-H1\u304c\u3044\u305a\u308c\u3082\u6709\u610f\u306b\u4f4e\u4e0b<\/strong>\u3057\u305f\u4e00\u65b9\u3001DPP-4\u963b\u5bb3\u85ac\u7fa4\u3067\u306fHbA1c\u306f\u4f4e\u4e0b\u3057\u305f\u3082\u306e\u306e\u8840\u4e2dMG-H1\u306f\u6709\u610f\u306b\u5909\u5316\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8457\u8005\u3089\u306f\u3001SGLT2\u963b\u5bb3\u85ac\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u52b9\u679c\u306b\u306f\u8840\u4e2dAGE\u4f4e\u4e0b\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306b\u3088\u308bAGE-RAGE\u8ef8\u6291\u5236\uff08Mol Med 2025, PMC11887197\uff09<\/p>\n

\u80a5\u6e802\u578b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u306edb\/db\u30de\u30a6\u30b9\u306b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u309213\u9031\u6295\u4e0e\u3057\u305f\u8a66\u9a13\u3067\u306f\u3001\u814e\u81d3\u3068\u8102\u80aa\u7d44\u7e54\u3067AGE-RAGE\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u6291\u5236\u3055\u308c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u814e\u6a5f\u80fd\u30fb\u4ee3\u8b1d\u6307\u6a19\u304c\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002SGLT2\u963b\u5bb3\u85ac\u306e\u814e\u4fdd\u8b77\u30fb\u5fc3\u4fdd\u8b77\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3068\u3057\u3066AGE-RAGE\u6291\u5236\u304c\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u88cf\u4ed8\u3051\u308b\u7814\u7a76\u3067\u3059\u3002<\/p>\n<\/div>\n\n\n
\n6-3<\/text><\/svg>\n<\/td>\n\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac \u2015 \u4f53\u91cd\u6e1b\u5c11\u3092\u4ecb\u3057\u305f\u9593\u63a5\u7684\u6297\u7cd6\u5316<\/h3>\n<\/td>\n<\/tr>\n<\/table>\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff08\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u7b49\uff09\u306f\u3001\u4f53\u91cd\u6e1b\u5c11\u3068\u8840\u7cd6\u6539\u5584\u3092\u901a\u3058\u3066\u5185\u56e0\u6027AGEs\u751f\u6210\u3092\u9593\u63a5\u7684\u306b\u6291\u5236\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002AGE-RAGE\u7d4c\u8def\u3078\u306e\u76f4\u63a5\u4f5c\u7528\u306b\u3064\u3044\u3066\u306e\u81e8\u5e8a\u7814\u7a76\u306f\u307e\u3060\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u84c4\u7a4d\u304c\u671f\u5f85\u3055\u308c\u308b\u9818\u57df\u3067\u3059\u3002<\/p>\n

\n

\u91cd\u8981\u306a\u6ce8\u610f\uff1a<\/strong>\u3053\u308c\u3089\u306e\u6297\u7cd6\u5316\u4f5c\u7528\u306f\u3001\u7cd6\u5c3f\u75c5\u30fb\u5fc3\u8840\u7ba1\u75c5\u30fb\u814e\u81d3\u75c5\u306a\u3069\u9069\u5fdc\u306e\u3042\u308b\u65b9\u306b\u51e6\u65b9\u3055\u308c\u308b\u85ac\u5264<\/strong>\u3067\u306e\u52b9\u679c\u3067\u3059\u3002\u5065\u5eb7\u306a\u65b9\u304c\u300c\u6297\u8001\u5316\u76ee\u7684\u300d\u3067\u81ea\u5df1\u5224\u65ad\u3067\u5185\u670d\u3059\u308b\u3053\u3068\u306f\u3001\u526f\u4f5c\u7528\uff08\u4e73\u9178\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u3001\u8131\u6c34\u3001\u6027\u5668\u611f\u67d3\u75c7\u3001\u30d3\u30bf\u30df\u30f3B12\u4f4e\u4e0b\u306a\u3069\uff09\u306e\u30ea\u30b9\u30af\u306e\u307f\u3092\u8ca0\u3046\u3053\u3068\u306b\u306a\u308a\u3001\u63a8\u5968\u3055\u308c\u307e\u305b\u3093\u3002\u3053\u308c\u3089\u306e\u6cbb\u7642\u306e\u9069\u5fdc\u306f\u3001\u5fc5\u305a\u4e3b\u6cbb\u533b\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u7cd6\u5c3f\u75c5\u85ac\u3068\u8001\u5316\u533b\u79d1\u5b66\uff08Geroscience\uff09\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u3001\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda<\/strong><\/a>\u8a18\u4e8b\u306b\u8a73\u7d30\u3092\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n
\n7<\/text><\/svg>\n<\/td>\n\n

\u7cd6\u5c3f\u75c5\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u65b9\u306f\u65e9\u3081\u306e\u5bfe\u7b56\u3092<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u300c\u89aa\u304c\u7cd6\u5c3f\u75c5\u3060\u3063\u305f\u306e\u3067\u3001\u81ea\u5206\u3082\u5fc3\u914d\u300d\u3068\u3044\u3046\u65b9\u306f\u3001\u3059\u3067\u306b\u8010\u7cd6\u80fd\u7570\u5e38\uff08\u5883\u754c\u578b\u7cd6\u5c3f\u75c5\uff09\u306e\u6bb5\u968e\u3067AGEs\u304c\u84c4\u7a4d\u3057\u59cb\u3081\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u304c\u9855\u5728\u5316\u3059\u308b\u524d\u304b\u3089\u98df\u4e8bAGEs\u524a\u6e1b\u30fb\u98df\u5f8c\u8840\u7cd6\u7ba1\u7406\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u304c\u3001\u5408\u4f75\u75c7\u306e\u767a\u75c7\u3092\u9045\u3089\u305b\u308b\u3046\u3048\u3067\u91cd\u8981\u3067\u3059\u3002\u5bb6\u65cf\u6b74\u306e\u3042\u308b\u65b9\u306e\u65e9\u671f\u5bfe\u7b56\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u89aa\u304c\u7cd6\u5c3f\u75c5\u3060\u3068\u81ea\u5206\u3082\uff1f\uff5c\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u4eba\u306e\u65e9\u671f\u5bfe\u7b56\u30fb\u62e1\u5927\u8102\u8cea\u691c\u67fb\u30fbFH\u3092\u89e3\u8aac\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n
\n8<\/text><\/svg>\n<\/td>\n\n

\u5f53\u9662\u3067\u306e\u500b\u5225\u5316\u30a2\u30d7\u30ed\u30fc\u30c1 \u2015 \u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u3068\u6cbb\u7642\u306e\u9023\u643a<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u5f53\u9662\u3067\u306f\u3001AGEs\u5bfe\u7b56\u3092\u300c\u6307\u5c0e\u300d\u3060\u3051\u3067\u7d42\u308f\u3089\u305b\u305a\u3001\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\uff08\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff1aSAF\uff09\u3067\u898b\u3048\u308b\u5316<\/strong>\u3057\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u30fb\u85ac\u5264\u6cbb\u7642\u306e\u52b9\u679c\u3092\u5ba2\u89b3\u7684\u306b\u8a55\u4fa1\u3059\u308b\u4ed5\u7d44\u307f\u3092\u53d6\u308a\u5165\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n\n\n\n\n
\u30b9\u30c6\u30c3\u30d7<\/th>\n\u5185\u5bb9<\/th>\n<\/tr>\n
\u2460\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6e2c\u5b9a<\/td>\n\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\uff08SAF\u3001\u7d0412\u79d2\u30fb\u63a1\u8840\u4e0d\u8981\uff09\u3067AGE\u84c4\u7a4d\u91cf\u3092\u300c\u5e74\u9f62\u76f8\u5f53\u300d\u300c\u5b9f\u5e74\u9f62\u3088\u308a\u9ad8\u3044\u300d\u306a\u3069\u8a55\u4fa1<\/td>\n<\/tr>\n
\u2461\u751f\u6d3b\u7fd2\u6163\u306e\u8a55\u4fa1<\/td>\n\u98df\u4e8b\u5185\u5bb9\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u7fd2\u6163\u30fb\u7761\u7720\u30fb\u55ab\u7159\u30fb\u30b9\u30c8\u30ec\u30b9\u3092\u554f\u8a3a\u3067\u78ba\u8a8d\u3001\u6539\u5584\u30dd\u30a4\u30f3\u30c8\u3092\u5171\u6709<\/td>\n<\/tr>\n
\u2462CGM\u306e\u6d3b\u7528\uff08\u5fc5\u8981\u6642\uff09<\/td>\n\u98df\u5f8c\u8840\u7cd6\u306e\u500b\u5225\u30d1\u30bf\u30fc\u30f3\u30922\u9031\u9593\u53ef\u8996\u5316\u3057\u3001\u81ea\u5206\u306b\u3068\u3063\u3066\u306e\u9ad8\u8840\u7cd6\u98df\u3092\u7279\u5b9a<\/td>\n<\/tr>\n
\u2463\u85ac\u5264\u306e\u6700\u9069\u5316<\/td>\n\u7cd6\u5c3f\u75c5\u30fb\u8102\u8cea\u7570\u5e38\u30fb\u9ad8\u8840\u5727\u3092\u304a\u6301\u3061\u306e\u65b9\u306b\u306f\u3001\u6297\u7cd6\u5316\u4f5c\u7528\u3082\u52a0\u5473\u3057\u305f\u500b\u5225\u5316\u51e6\u65b9\u3092\u691c\u8a0e<\/td>\n<\/tr>\n
\u2464\u5b9a\u671f\u518d\u6e2c\u5b9a<\/td>\n3\u301c6\u304b\u6708\u5f8c\u306bSAF\u3092\u518d\u6e2c\u5b9a\u3057\u3001\u6539\u5584\u30fb\u7dad\u6301\u30fb\u60aa\u5316\u3092\u5ba2\u89b3\u7684\u306b\u8a55\u4fa1<\/td>\n<\/tr>\n<\/table>\n

\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u8cbb\u7528\u30fb\u5b9f\u65bd\u306e\u6d41\u308c\u306f\u3001AGEs\u7dcf\u8ad6\u8a18\u4e8b<\/strong><\/a>\u306b\u8a73\u3057\u304f\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n
\n9<\/text><\/svg>\n<\/td>\n\n

\u9662\u9577\u304b\u3089 \u2015 \u6297\u7cd6\u5316\u306f\u300c\u7279\u5225\u306a\u3053\u3068\u300d\u3067\u306f\u306a\u304f\u300c\u65e5\u3005\u306e\u5c0f\u3055\u306a\u9078\u629e\u300d<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

\u7cd6\u5316\u5bfe\u7b56\u3068\u805e\u304f\u3068\u300c\u9ad8\u4fa1\u306a\u30b5\u30d7\u30ea\u300d\u300c\u7279\u5225\u306a\u691c\u67fb\u300d\u3092\u60f3\u50cf\u3055\u308c\u308b\u65b9\u304c\u591a\u3044\u306e\u3067\u3059\u304c\u3001\u672c\u8cea\u306f\u6bce\u65e5\u306e\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u30fb\u7761\u7720\u306e\u5c0f\u3055\u306a\u9078\u629e\u306e\u7a4d\u307f\u91cd\u306d<\/strong>\u3067\u3059\u3002\u300c\u713c\u304d\u9ce5\u3092\u90311\u56de\u6e1b\u3089\u3057\u3066\u6c34\u708a\u304d\u306b\u7f6e\u304d\u63db\u3048\u308b\u300d\u300c\u63da\u3052\u7269\u306e\u524d\u306b\u30ec\u30e2\u30f3\u3067\u30de\u30ea\u30cd\u3059\u308b\u300d\u300c\u98df\u5f8c\u306b5\u5206\u6563\u6b69\u3059\u308b\u300d\u2500\u2500\u3053\u3046\u3057\u305f\u4e00\u3064\u3072\u3068\u3064\u306e\u5c0f\u3055\u306a\u5909\u5316\u304c\u300110\u5e74\u5f8c\u30fb20\u5e74\u5f8c\u306e\u8840\u7ba1\u30fb\u814e\u81d3\u30fb\u9aa8\u30fb\u8133\u306e\u72b6\u614b\u3092\u78ba\u5b9f\u306b\u5909\u3048\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n

\u9662\u9577\u4e94\u85e4\u306e\u8457\u66f8 \u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f<\/strong>\uff08\u30a2\u30b9\u30b3\u30e0\u30012024\u5e74\uff09<\/a>\u3067\u3082\u3001\u5185\u81d3\u8102\u80aa\u30fb\u4e2d\u6027\u8102\u80aa\u30fb\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0b\u3052\u306a\u304c\u3089\u7cd6\u5316\u5bfe\u7b56\u306b\u3082\u3064\u306a\u304c\u308b\u30b9\u30fc\u30d7\u30ec\u30b7\u30d4\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002\u300c\u7121\u7406\u306a\u304f\u7d9a\u3051\u3089\u308c\u308b\u300d\u3092\u6700\u91cd\u8996\u3057\u305f\u5b9f\u8df5\u66f8\u3067\u3059\u306e\u3067\u3001\u5408\u308f\u305b\u3066\u3054\u6d3b\u7528\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n
\n10<\/text><\/svg>\n<\/td>\n\n

\u307e\u3068\u3081 \u2015 \u4eca\u65e5\u304b\u3089\u59cb\u3081\u3089\u308c\u308b5\u3064\u306e\u30a2\u30af\u30b7\u30e7\u30f3<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n\n\n\n\n\n\n\n
No.<\/th>\n\u30a2\u30af\u30b7\u30e7\u30f3<\/th>\n<\/tr>\n
1<\/td>\n\u8abf\u7406\u6cd5\u3092\u4e00\u6bb5\u968e\u4e0b\u3052\u308b<\/strong>\u3002\u63da\u3052\u308b\u2192\u713c\u304f\u3001\u713c\u304f\u2192\u84b8\u3059\u30fb\u716e\u308b\u306b\u7f6e\u304d\u63db\u3048\u308b<\/td>\n<\/tr>\n
2<\/td>\n\u98df\u4e8b\u306e\u6700\u521d\u306b\u91ce\u83dc\u30fb\u6d77\u85fb\u30fb\u304d\u306e\u3053<\/strong>\u3092\u98df\u3079\u308b\u300c\u98df\u7269\u7e4a\u7dad\u30d5\u30a1\u30fc\u30b9\u30c8\u300d\u3092\u5fb9\u5e95\u3059\u308b<\/td>\n<\/tr>\n
3<\/td>\n\u98df\u5f8c10\u301c20\u5206\u306f\u5ea7\u3089\u306a\u3044<\/strong>\u3002\u5bb6\u4e8b\u30fb\u8cb7\u3044\u7269\u30fb\u8fd1\u6240\u306e\u6563\u6b69\u3092\u300c\u8840\u7cd6\u306e\u85ac\u300d\u3068\u8003\u3048\u308b<\/td>\n<\/tr>\n
4<\/td>\n\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u3067\u73fe\u5728\u5730\u3092\u78ba\u8a8d<\/strong>\u3002\u6570\u5024\u306e\u898b\u3048\u308b\u5316\u304c\u884c\u52d5\u5909\u5bb9\u306e\u6700\u3082\u5f37\u3044\u52d5\u6a5f\u306b\u306a\u308b<\/td>\n<\/tr>\n
5<\/td>\n\u7cd6\u5c3f\u75c5\u30fb\u524d\u7cd6\u5c3f\u75c5\u3092\u304a\u6301\u3061\u306e\u65b9\u306f\u4e3b\u6cbb\u533b\u306b\u76f8\u8ac7<\/strong>\u3002\u6297\u7cd6\u5316\u4f5c\u7528\u3082\u52a0\u5473\u3057\u305f\u500b\u5225\u5316\u6cbb\u7642\u3092\u4e00\u7dd2\u306b\u8003\u3048\u308b<\/td>\n<\/tr>\n<\/table>\n

\u300c\u4f55\u304b\u3089\u59cb\u3081\u308c\u3070\u3088\u3044\u304b\u5206\u304b\u3089\u306a\u3044\u300d\u300c\u81ea\u5206\u306eAGE\u30b9\u30b3\u30a2\u3092\u77e5\u308a\u305f\u3044\u300d\u300c\u7cd6\u5c3f\u75c5\u85ac\u306e\u9078\u629e\u3092\u898b\u76f4\u3057\u305f\u3044\u300d\u2500\u2500\u305d\u3093\u306a\u65b9\u306f\u3001\u305c\u3072\u7530\u5712\u8abf\u5e03\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u9662\u9577\u4e94\u85e4\u304c\u3001\u3042\u306a\u305f\u306e\u751f\u6d3b\u80cc\u666f\u30fb\u5065\u5eb7\u72b6\u614b\u306b\u5408\u308f\u305b\u305f\u6297\u7cd6\u5316\u30d7\u30e9\u30f3\u3092\u3054\u63d0\u6848\u3057\u307e\u3059\u3002<\/p>\n\n\n
\n11<\/text><\/svg>\n<\/td>\n\n

\u53c2\u8003\u6587\u732e<\/h2>\n<\/td>\n<\/tr>\n<\/table>\n

1. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc<\/em>. 2010;110(6):911-916.e12.<\/p>\n

2. Vlassara H, Cai W, Tripp E, et al. Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial. Diabetologia<\/em>. 2016;59(10):2181-2192.<\/p>\n

3. Uribarri J, Cai W, Ramdas M, et al. Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. Diabetes Care<\/em>. 2011;34(7):1610-1616.<\/p>\n

4. Kahleova H, Znayenko-Miller T, Uribarri J, Holubkov R, Barnard ND. Dietary advanced glycation products and their associations with insulin sensitivity and body weight: A 16-week randomized clinical trial. Obes Sci Pract<\/em>. 2023.<\/p>\n

5. Kahleova H, Znayenko-Miller T, Motoa G, et al. Dietary advanced glycation end-products and their associations with body weight on a Mediterranean diet and low-fat vegan diet: a randomized, cross-over trial. Front Nutr<\/em>. 2024;11:1426642.<\/p>\n

6. Tsuruta H, Ono J. Effects of SGLT2 Inhibitors and DPP-4 Inhibitors on Advanced Glycation End Products. J Clin Med Res<\/em>. 2024 (PMID 38286421).<\/p>\n

7. Ishibashi Y, Matsui T, Maeda S, et al. Empagliflozin ameliorates renal and metabolic derangements in obese type 2 diabetic mice by blocking advanced glycation end product-receptor axis. Mol Med<\/em>. 2025;31:7 (PMC11887197).<\/p>\n

8. Han L, Fan Q, Wang K, et al. Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE\/NF\u03baB Pathway Suppression. J Diabetes Res<\/em>. 2016 (PMID 27761470).<\/p>\n

9. Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S. Metformin inhibits advanced glycation end products (AGEs)-induced growth and VEGF expression in MCF-7 breast cancer cells by suppressing AGEs receptor expression via AMP-activated protein kinase. Horm Metab Res<\/em>. 2012;44(12):891-895.<\/p>\n

10. Schurman L, McCarthy AD, Sedlinsky C, et al. Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells. Exp Clin Endocrinol Diabetes<\/em>. 2008;116(6):333-340.<\/p>\n

11. Waqas K, et al. Skin Autofluorescence, a Noninvasive Biomarker of Advanced Glycation End-products, Is Associated With Frailty: The Rotterdam Study. J Gerontol A Biol Sci Med Sci<\/em>. 2022;77(10):2032-2039.<\/p>\n

12. \u4e94\u85e4\u826f\u5c06\u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f\u30a2\u30b9\u30b3\u30e0, 2024.<\/p>\n

<\/p>\n

\n
\n
GORYOKAI GROUP<\/div>\n
\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662<\/div>\n<\/div>\n
\n\n\n\n
\u5185\u79d1<\/td>\n\u5c0f\u5150\u79d1<\/td>\n\u7cd6\u5c3f\u75c5\u5185\u79d1<\/td>\n\u4ee3\u8b1d\u5185\u79d1<\/td>\n\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/td>\n<\/tr>\n
\u76ae\u819a\u79d1<\/td>\n\u751f\u6d3b\u7fd2\u6163\u75c5<\/td>\n\u8a2a\u554f\u8a3a\u7642<\/td>\n\u5fc3\u7642\u5185\u79d1<\/td>\n\u5065\u5eb7\u8a3a\u65ad<\/td>\n<\/tr>\n<\/table>\n

\u6771\u4eac\u90fd\u5927\u7530\u533a\u7530\u5712\u8abf\u5e03\u672c\u753a40-12 \u30b3\u30f3\u30c9\u7530\u5712\u8abf\u5e03\uff12\u968e<\/p>\n

\u591a\u6469\u5ddd\u99c5\uff08\u6771\u6025\u6771\u6a2a\u7dda\u30fb\u591a\u6469\u5ddd\u7dda\uff09\u5f92\u6b695\u5206<\/p>\n

\u571f\u66dc\u65e5\u3082\u5348\u524d\u8a3a\u7642\u3042\u308a<\/span><\/p>\n\n\n\n\n
\u8a3a\u7642\u6642\u9593<\/th>\n\u6708<\/th>\n\u706b<\/th>\n\u6c34<\/th>\n\u6728<\/th>\n\u91d1<\/th>\n\u571f<\/th>\n\u65e5\u795d<\/th>\n<\/tr>\n
\u5348\u524d 9:00\u301c12:00<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u4f11<\/td>\n<\/tr>\n
\u5348\u5f8c 15:30\u301c19:00<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u4f11<\/td>\n\u4f11<\/td>\n<\/tr>\n<\/table>\n

\u4f11\u8a3a\u65e5\uff1a\u571f\u66dc\u5348\u5f8c\u30fb\u65e5\u66dc\u30fb\u795d\u65e5<\/p>\n\n\n
\n
\n\"CLINICS\"
\nWEB\u4e88\u7d04<\/span>
\n<\/a>\n<\/td>\n		\n
\n\"CLINICS\"
\nWEB\u554f\u8a3a<\/span>
\n<\/a>\n<\/td>\n		\n
\n<\/svg>
\nLINE<\/span>
\n<\/a>\n<\/td>\n		\n
\n<\/svg>
\n03-3721-5222<\/span>
\n<\/a>\n<\/td>\n<\/tr>\n<\/table>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u7686\u3055\u307e\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u306e\u4e94\u85e4\u826f\u5c06\u3067\u3059\u3002 \u524d\u56de\u306e\u30d6\u30ed\u30b0\u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185\u300d\u3067\u306f\u3001AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u304c\u52d5\u8108\u786c\u5316\u30fb\u7cd6…<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[459,566,22,814,676,4,103,697,353,14,12,344],"tags":[504,955,731,505,245,244,35,506,507,772],"class_list":["post-6872","post","type-post","status-publish","format-standard","hentry","category-459","category-566","category-22","category-814","category-676","category-4","category-103","category-697","category-353","category-14","category-12","category-344","tag-age","tag-sglt2","tag-731","tag-505","tag-245","tag-244","tag-35","tag-506","tag-507","tag-772","wpcat-459-id","wpcat-566-id","wpcat-22-id","wpcat-814-id","wpcat-676-id","wpcat-4-id","wpcat-103-id","wpcat-697-id","wpcat-353-id","wpcat-14-id","wpcat-12-id","wpcat-344-id"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts\/6872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/comments?post=6872"}],"version-history":[{"count":2,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts\/6872\/revisions"}],"predecessor-version":[{"id":6875,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts\/6872\/revisions\/6875"}],"wp:attachment":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/media?parent=6872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/categories?post=6872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/tags?post=6872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}