{"id":6864,"date":"2026-04-24T22:18:44","date_gmt":"2026-04-24T13:18:44","guid":{"rendered":"https:\/\/www.takeuchi-iin.jp\/blog\/?p=6864"},"modified":"2026-04-24T22:48:14","modified_gmt":"2026-04-24T13:48:14","slug":"diabetes-treatment-metformin-sglt2-cgm-geroscience-2026","status":"publish","type":"post","link":"https:\/\/www.takeuchi-iin.jp\/blog\/diabetes-treatment-metformin-sglt2-cgm-geroscience-2026\/","title":{"rendered":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\uff5c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u30fbCGM\u500b\u5225\u5316\uff0b\u6297\u8001\u5316\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3010\u7530\u5712\u8abf\u5e03\u3011"},"content":{"rendered":"<p>\u3053\u308c\u307e\u3067\u306e\u30d6\u30ed\u30b0\u30b7\u30ea\u30fc\u30ba\u3067\u306f\u3001<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%8e%e7%b3%96%e5%b0%bf%e7%97%85%e5%88%9d%e6%9c%9f%e7%97%87%e7%8a%b6%e3%80%8f%e9%9a%a0%e3%82%8c%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%ab%e3%81%84%e3%81%a1%e6%97%a9%e3%81%8f%e6%b0%97%e3%81%a5%e3%81%93\/\">\u5883\u754c\u578b\u7cd6\u5c3f\u75c5\u306e\u65e9\u671f\u767a\u898b<\/a>\u3001<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/metabolic-syndrome-diabetes-progression-2026\/\">\u30e1\u30bf\u30dc\u304b\u3089\u306e\u9032\u884c\u30e1\u30ab\u30cb\u30ba\u30e0<\/a>\u3001<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/diabetes-family-history-fh-2026\/\">\u5bb6\u65cf\u6b74\u3068\u907a\u4f1d\u7684\u30ea\u30b9\u30af<\/a>\u306b\u3064\u3044\u3066\u304a\u4f1d\u3048\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7d9a\u7de8\u3067\u306f\u3001\u3053\u308c\u307e\u3067\u306e<strong>\u300c\u4e88\u9632\u300d\u300c\u767a\u898b\u300d<\/strong>\u306e\u30b9\u30c6\u30fc\u30b8\u304b\u3089\u4e00\u6b69\u9032\u3093\u3067\u3001\u5b9f\u969b\u306b\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u305f\u65b9\u306e\u305f\u3081\u306e<strong>\u300c\u6cbb\u7642\u300d\u306e\u6700\u524d\u7dda<\/strong>\u306b\u30d5\u30a9\u30fc\u30ab\u30b9\u3057\u307e\u3059\u3002\u7279\u306b\u6ce8\u76ee\u3044\u305f\u3060\u304d\u305f\u3044\u306e\u306f\u3001\u3053\u306e10\u5e74\u3067\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306f\u5927\u304d\u306a\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8\u3092\u8fce\u3048\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u5358\u306b\u8840\u7cd6\u5024\u3092\u4e0b\u3052\u308b\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u5fc3\u81d3\u30fb\u814e\u81d3\u3092\u5b88\u308b\u85ac\u5264<\/strong>\u306e\u767b\u5834\u3001<strong>CGM\uff08\u6301\u7d9a\u8840\u7cd6\u30e2\u30cb\u30bf\u30fc\uff09<\/strong>\u306b\u3088\u308b\u500b\u5225\u5316\u533b\u7642\u3001\u305d\u3057\u3066<strong>\u75c5\u614b\u306b\u5fdc\u3058\u305f\u85ac\u306e\u4f7f\u3044\u5206\u3051<\/strong>\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2024\/04\/image-55.png\" alt=\"\u7cd6\u5c3f\u75c5\u6cbb\u7642\" \/><\/p>\n<p>\u4eca\u56de\u306e\u30d6\u30ed\u30b0\u3067\u306f<\/p>\n<p>\u3000\u25a0\u65e5\u672c\u3068\u6b27\u7c73\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u6226\u7565\u306e\u6839\u672c\u7684\u306a\u9055\u3044<br \/>\n\u3000\u25a0\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u250060\u5e74\u4ee5\u4e0a\u4f7f\u308f\u308c\u308b\u300c\u7b2c\u4e00\u9078\u629e\u85ac\u300d\u306e\u5b9f\u529b<br \/>\n\u3000\u25a0SGLT2\u963b\u5bb3\u85ac\u2500\u5fc3\u81d3\u3068\u814e\u81d3\u3092\u5b88\u308b\u65b0\u4e16\u4ee3\u306e\u7cd6\u5c3f\u75c5\u85ac<br \/>\n\u3000\u25a0GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u2500\u8840\u7cd6\u30fb\u4f53\u91cd\u30fb\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u540c\u6642\u306b\u6539\u5584<br \/>\n\u3000\u25a0\u75c5\u614b\u5225\u306e\u85ac\u5264\u9078\u629e\u2500\u80a5\u6e80\u578b\u30fb\u75e9\u305b\u578b\u30fb\u9ad8\u9f62\u8005\u30fbCKD\u4f75\u767a<br \/>\n\u3000\u25a0CGM\uff08\u30ea\u30d6\u30ec\uff09\u306b\u3088\u308b\u500b\u5225\u5316\u6cbb\u7642\u306e\u5b9f\u969b<br \/>\n\u3000\u25a0<strong>\u7cd6\u5c3f\u75c5\u85ac\u306f\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u304b\uff1f \u2500 Geroscience\uff08\u8001\u5316\u533b\u79d1\u5b66\uff09\u306e\u8996\u70b9<\/strong><br \/>\n\u3000\u25a0\u5408\u4f75\u75c7\uff08\u7db2\u819c\u75c7\u30fb\u814e\u75c7\u30fb\u795e\u7d4c\u969c\u5bb3\u30fb\u5fc3\u8840\u7ba1\u75c5\uff09\u306e\u65e9\u671f\u767a\u898b\u3068\u4e88\u9632<br \/>\n\u3000\u25a0\u98df\u4e8b\u7642\u6cd5\u2500\u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f\u306e\u8003\u3048\u65b9<\/p>\n<p>\u306b\u3064\u3044\u3066\u304a\u4f1d\u3048\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<figure class=\"wp-block-image size-full\"> <img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2026\/04\/62d41b5c47f4df193a489a5822470911.jpg\" alt=\"\" class=\"wp-image-3403\" style=\"width:100%;height:auto;display:block;\" \/> <\/figure>\n<p><!-- ===== \u30dd\u30a4\u30f3\u30c8\u30dc\u30c3\u30af\u30b9\uff08\u9752\uff09 ===== --><\/p>\n<div style=\"background:#e3f2fd; border-left:6px solid #1976d2; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#0d47a1; font-weight:bold; margin:0 0 10px 0; font-size:1.1em;\">\u3053\u306e\u8a18\u4e8b\u306e\u30dd\u30a4\u30f3\u30c8<\/p>\n<p style=\"margin:0; line-height:1.8;\">\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u76ee\u7684\u306f\u300cHbA1c\u3092\u4e0b\u3052\u308b\u3053\u3068\u300d\u3067\u306f\u306a\u304f\u3001<strong>\u5408\u4f75\u75c7\u3092\u9632\u3044\u3067\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068<\/strong>\u3067\u3059\u3002\u8fd1\u5e74\u3001SGLT2\u963b\u5bb3\u85ac\u3084GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u767b\u5834\u306b\u3088\u308a\u3001<strong>\u5358\u306a\u308b\u8840\u7cd6\u964d\u4e0b\u85ac\u3067\u306f\u306a\u304f\u5fc3\u81d3\u30fb\u814e\u81d3\u3092\u5b88\u308b\u85ac<\/strong>\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u304c\u5909\u308f\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u65e5\u672c\u3067\u306f\u3001\u6b27\u7c73\u578b\u306e\u300c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u4e00\u629e\u306e\u7b2c\u4e00\u9078\u629e\u300d\u3067\u306f\u306a\u304f\u3001<strong>\u60a3\u8005\u3055\u3093\u306e\u75c5\u614b\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u578b\u304b\u62b5\u6297\u6027\u578b\u304b\u3001\u80a5\u6e80\u306e\u6709\u7121\u3001\u814e\u6a5f\u80fd\u306a\u3069\uff09\u306b\u5fdc\u3058\u3066\u85ac\u3092\u9078\u3076<\/strong>\u500b\u5225\u5316\u6226\u7565\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u65e5\u672c\u3068\u6b27\u7c73\u306e\u6cbb\u7642\u6226\u7565\u306f\u306a\u305c\u9055\u3046\u306e\u304b<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u3044\u308b\u3068\u3001\u300c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u4e16\u754c\u6a19\u6e96\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u300d\u3068\u3044\u3046\u60c5\u5831\u306b\u89e6\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u65e5\u672c\u306e\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001<strong>\u4e00\u5f8b\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3092\u5b9a\u3081\u3066\u3044\u307e\u305b\u3093<\/strong>\u3002\u3053\u308c\u306f\u65e5\u672c\u306e\u6cbb\u7642\u304c\u9045\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001<strong>\u65e5\u672c\u4eba\u3068\u6b27\u7c73\u4eba\u306e\u7cd6\u5c3f\u75c5\u306e\u75c5\u614b\u304c\u6839\u672c\u7684\u306b\u7570\u306a\u308b<\/strong>\u305f\u3081\u3067\u3059\u3002<\/p>\n<p>\u6b27\u7c73\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u306f\u3001\u591a\u304f\u304c\u9ad8\u5ea6\u306a\u80a5\u6e80\u3068\u5f37\u3044\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u80cc\u666f\u306b\u767a\u75c7\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001\u65e5\u672c\u4eba\u3092\u542b\u3080\u6771\u30a2\u30b8\u30a2\u4eba\u3067\u306f\u3001<strong>\u81b5\u03b2\u7d30\u80de\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u304c\u907a\u4f1d\u7684\u306b\u4f4e\u3044<\/strong>\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u80a5\u6e80\u304c\u8efd\u5ea6\u3067\u3082\u7cd6\u5c3f\u75c5\u3092\u767a\u75c7\u3059\u308b\u300c\u75e9\u305b\u578b\u7cd6\u5c3f\u75c5\u300d\u306e\u65b9\u304c\u534a\u6570\u8fd1\u304f\u3092\u5360\u3081\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6b27\u7c73\u3067\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6226\u7565\u304c\u3001\u65e5\u672c\u4eba\u306b\u306f\u305d\u306e\u307e\u307e\u9069\u7528\u3067\u304d\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n<p><!-- ===== \u30a8\u30d3\u30c7\u30f3\u30b9\u30dc\u30c3\u30af\u30b9\uff08\u7dd1\uff09 ===== --><\/p>\n<div style=\"background:#e8f5e9; border-left:6px solid #388e3c; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#1b5e20; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff1a\u718a\u672c\u30b9\u30bf\u30c7\u30a3\uff08Kumamoto Study\uff09<\/p>\n<p style=\"margin:0; line-height:1.8;\">1995\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u65e5\u672c\u767a\u306e\u753b\u671f\u7684\u7814\u7a76\u3002\u65e5\u672c\u4eba2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005110\u540d\u3092\u5bfe\u8c61\u306b\u3001\u5f37\u5316\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\u3068\u5f93\u6765\u7642\u6cd5\u30926\u301c8\u5e74\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001<strong>\u5f37\u5316\u7642\u6cd5\u7fa4\u3067\u7db2\u819c\u75c7\u306e\u9032\u884c\u309269%\u3001\u814e\u75c7\u306e\u9032\u884c\u309270%\u6291\u5236<\/strong>\u3057\u307e\u3057\u305f\u3002HbA1c 6.5%\u672a\u6e80\u3001\u7a7a\u8179\u6642\u8840\u7cd6110mg\/dL\u672a\u6e80\u3001\u98df\u5f8c2\u6642\u9593\u8840\u7cd6180mg\/dL\u672a\u6e80\u3068\u3044\u3046\u65e5\u672c\u72ec\u81ea\u306e\u7ba1\u7406\u76ee\u6a19\u306e\u6839\u62e0\u3068\u306a\u308a\u3001\u73fe\u5728\u3082\u65e5\u672c\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u790e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\uff08Ohkubo Y et al. Diabetes Res Clin Pract 1995; Shichiri M et al. Diabetes Care 2000\uff09\u3002<\/p>\n<\/div>\n<p>\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u306f2022\u5e74\u306b\u300c<strong>2\u578b\u7cd6\u5c3f\u75c5\u306e\u85ac\u7269\u7642\u6cd5\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0<\/strong>\u300d\u3092\u516c\u8868\u3057\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u306f\u3001Step1\u3067<strong>\u300c\u75c5\u614b\u306b\u5fdc\u3058\u305f\u85ac\u5264\u9078\u629e\u300d<\/strong>\u3001Step2\u3067<strong>\u300c\u5b89\u5168\u6027\u3078\u306e\u914d\u616e\u300d<\/strong>\u3001Step3\u3067<strong>\u300cAdditional benefits\uff08\u5408\u4f75\u75c7\u4e88\u9632\u52b9\u679c\uff09\u300d<\/strong>\u306e\u89b3\u70b9\u304b\u3089\u85ac\u5264\u3092\u9078\u3076\u30013\u30b9\u30c6\u30c3\u30d7\u306e\u8003\u3048\u65b9\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8003\u3048\u65b9\u304c\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u57fa\u672c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\uff08\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u300e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u30ac\u30a4\u30c92024-2025\u300f\uff09\u3002<\/p>\n<table style=\"width:100%; border-collapse:collapse; margin:20px 0; font-size:0.95em;\">\n<thead>\n<tr style=\"background:#00796b; color:#fff;\">\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u9805\u76ee<\/th>\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u6b27\u7c73\uff08ADA\/EASD\uff09<\/th>\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u65e5\u672c\uff08\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\uff09<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u60a3\u8005\u306e\u4e3b\u306a\u75c5\u614b<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u80a5\u6e80\u578b\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u4e3b\u4f53<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u75e9\u305b\u578b\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u3082\u534a\u6570\u8fd1\u304f<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u7b2c\u4e00\u9078\u629e\u85ac<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3092\u63a8\u5968\uff08\u6b74\u53f2\u7684\u306b\u306f\uff09<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u75c5\u614b\u306b\u5fdc\u3058\u3066\u9078\u629e\uff08\u4e00\u5f8b\u306e\u7b2c\u4e00\u9078\u629e\u306a\u3057\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u6cbb\u7642\u306e\u8003\u3048\u65b9<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u30fb\u814e\u75c7\u306e\u6709\u7121\u3067\u5206\u5c90<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">3\u30b9\u30c6\u30c3\u30d7\uff08\u75c5\u614b\u2192\u5b89\u5168\u6027\u2192\u8ffd\u52a0\u52b9\u679c\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u7642\u6cd5\u306e\u4f4d\u7f6e\u3065\u3051<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u6700\u7d42\u624b\u6bb5\u3068\u3057\u3066\u5f8c\u56de\u3057<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u5fc5\u8981\u6642\u306b\u306f\u65e9\u671f\u5c0e\u5165\u3092\u63a8\u5968\uff08\u718a\u672c\u30b9\u30bf\u30c7\u30a3\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u250060\u5e74\u4ee5\u4e0a\u4f7f\u308f\u308c\u308b\u300c\u7b2c\u4e00\u9078\u629e\u85ac\u300d\u306e\u5b9f\u529b<\/h2>\n<p>\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306f1957\u5e74\u306b\u30d5\u30e9\u30f3\u30b9\u3067\u767a\u58f2\u3055\u308c\u305f\u30d3\u30b0\u30a2\u30ca\u30a4\u30c9\u7cfb\u306e\u7cd6\u5c3f\u75c5\u85ac\u3067\u3059\u3002\u5b9f\u306b60\u5e74\u4ee5\u4e0a\u306e\u6b74\u53f2\u304c\u3042\u308a\u306a\u304c\u3089\u3001\u4eca\u306a\u304a\u4e16\u754c\u3067\u6700\u3082\u51e6\u65b9\u3055\u308c\u3066\u3044\u308b\u7cd6\u5c3f\u75c5\u85ac\u306e\u4e00\u3064\u3002\u5b89\u4fa1\u3067\u3001\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u306b\u512a\u308c\u3001\u4f53\u91cd\u5897\u52a0\u3092\u8d77\u3053\u3055\u305a\u3001\u4f4e\u8840\u7cd6\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u3044\u3068\u3044\u3046\u512a\u308c\u305f\u7279\u6027\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n<p><!-- ===== \u30e1\u30ab\u30cb\u30ba\u30e0\u56f3\u89e3\uff08\u7d2b\uff09 ===== --><\/p>\n<div style=\"background:#f3e5f5; border-left:6px solid #7b1fa2; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#4a148c; font-weight:bold; margin:0 0 14px 0; font-size:1.05em;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e3\u3064\u306e\u4f5c\u7528\u6a5f\u5e8f<\/p>\n<table style=\"width:100%; border-collapse:collapse; margin:0;\">\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">1<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u809d\u81d3\u306e\u7cd6\u65b0\u751f\u3092\u6291\u5236<\/strong><br \/>\u4e3b\u4f5c\u7528\u3002\u809d\u81d3\u3067\u4f5c\u3089\u308c\u308b\u7cd6\uff08\u7cd6\u65b0\u751f\uff09\u3092\u6e1b\u3089\u3057\u3001\u7a7a\u8179\u6642\u8840\u7cd6\u3092\u6539\u5584\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">2<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u7b4b\u8089\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u6539\u5584<\/strong><br \/>\u7b4b\u8089\u3067\u306e\u7cd6\u53d6\u308a\u8fbc\u307f\u3092\u4fc3\u9032\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u6539\u5584\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">3<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u8178\u7ba1\u304b\u3089\u306e\u7cd6\u5438\u53ce\u3092\u7de9\u3084\u304b\u306b<\/strong><br \/>\u6d88\u5316\u7ba1\u3067\u306e\u7cd6\u5438\u53ce\u3092\u9045\u3089\u305b\u3001\u98df\u5f8c\u8840\u7cd6\u306e\u6025\u4e0a\u6607\u3092\u6291\u3048\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/table>\n<\/div>\n<p><!-- ===== \u30a8\u30d3\u30c7\u30f3\u30b9\u30dc\u30c3\u30af\u30b9\uff08\u7dd1\uff09 ===== --><\/p>\n<div style=\"background:#e8f5e9; border-left:6px solid #388e3c; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#1b5e20; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aUKPDS 34\u8a66\u9a13\uff08\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u52b9\u679c\uff09<\/p>\n<p style=\"margin:0; line-height:1.8;\">1998\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u82f1\u56fd\u306e\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u3002\u904e\u4f53\u91cd\u306e\u65b0\u898f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005753\u540d\u3092\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u5f37\u5316\u7642\u6cd5\u7fa4\u3068\u98df\u4e8b\u7642\u6cd5\u7fa4\u306710.7\u5e74\u9593\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u7fa4\u3067\u306f<strong>\u7cd6\u5c3f\u75c5\u95a2\u9023\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c32%\u6e1b\u5c11\u3001\u5168\u6b7b\u4ea1\u304c36%\u6e1b\u5c11\u3001\u5fc3\u7b4b\u6897\u585e\u304c39%\u6e1b\u5c11<\/strong>\u3002\u3055\u3089\u306b\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3084\u30b9\u30eb\u30db\u30cb\u30eb\u5c3f\u7d20\u85ac\u3068\u6bd4\u8f03\u3057\u3066\u4f53\u91cd\u5897\u52a0\u3068\u4f4e\u8840\u7cd6\u304c\u5c11\u306a\u3044\u3053\u3068\u304b\u3089\u3001<strong>\u904e\u4f53\u91cd\u60a3\u8005\u306b\u304a\u3051\u308b\u7b2c\u4e00\u9078\u629e\u85ac<\/strong>\u3068\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u307e\u3057\u305f\uff08UKPDS 34 Group, Lancet 1998\uff09\u3002<\/p>\n<\/div>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c\u5411\u3044\u3066\u3044\u308b\u65b9<\/h3>\n<p>\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u65b9\u306b\u7279\u306b\u304a\u52e7\u3081\u3067\u3059\uff1a<\/p>\n<ul>\n<li>\u80a5\u6e80\u307e\u305f\u306f\u904e\u4f53\u91cd\uff08BMI 25\u4ee5\u4e0a\uff09\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u4e3b\u4f53\u306e\u65b9<\/li>\n<li>\u4f53\u91cd\u3092\u5897\u3084\u3057\u305f\u304f\u306a\u3044\u65b9<\/li>\n<li>\u98df\u5f8c\u8840\u7cd6\u304c\u9ad8\u3044\u65b9<\/li>\n<li>\u7d4c\u6e08\u7684\u306a\u8ca0\u62c5\u3092\u8efd\u304f\u3057\u305f\u3044\u65b9\uff08\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u85ac\u30671\u932010\u5186\u7a0b\u5ea6\uff09<\/li>\n<\/ul>\n<p><!-- ===== \u8b66\u544a\u30dc\u30c3\u30af\u30b9\uff08\u30aa\u30ec\u30f3\u30b8\uff09 ===== --><\/p>\n<div style=\"background:#fff3e0; border-left:6px solid #e65100; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#bf360c; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u4f7f\u7528\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u306a\u65b9<\/p>\n<p style=\"margin:0 0 8px 0; line-height:1.8;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306f\u6975\u3081\u3066\u7a00\u3067\u3059\u304c\u3001\u4e73\u9178\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u3068\u3044\u3046\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u65b9\u3067\u306f\u614e\u91cd\u6295\u4e0e\u307e\u305f\u306f\u7981\u5fcc\u3068\u306a\u308a\u307e\u3059\uff1a<\/p>\n<ul style=\"margin:6px 0 0 20px; line-height:1.8;\">\n<li>\u814e\u6a5f\u80fd\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u65b9\uff08eGFR 30\u672a\u6e80\u306f\u7981\u5fcc\uff09<\/li>\n<li>\u9ad8\u9f62\u8005\uff08\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u300e\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u9069\u6b63\u4f7f\u7528\u306b\u95a2\u3059\u308bRecommendation 2020\u300f\u3067\u306f75\u6b73\u4ee5\u4e0a\u306f\u614e\u91cd\u6295\u4e0e\uff09<\/li>\n<li>\u8131\u6c34\u3001\u5927\u91cf\u98f2\u9152\u3001\u5fc3\u4e0d\u5168\u30fb\u809d\u4e0d\u5168\u306e\u3042\u308b\u65b9<\/li>\n<li>\u30e8\u30fc\u30c9\u9020\u5f71\u5264\u4f7f\u7528\u524d\u5f8c\uff0848\u6642\u9593\u306e\u4f11\u85ac\u304c\u5fc5\u8981\uff09<\/li>\n<\/ul>\n<\/div>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">SGLT2\u963b\u5bb3\u85ac\u2500\u5fc3\u81d3\u3068\u814e\u81d3\u3092\u5b88\u308b\u65b0\u4e16\u4ee3\u306e\u7cd6\u5c3f\u75c5\u85ac<\/h2>\n<p>SGLT2\uff08Sodium-Glucose Cotransporter 2\uff09\u963b\u5bb3\u85ac\u306f\u3001\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6982\u5ff5\u3092\u4e00\u5909\u3055\u305b\u305f\u753b\u671f\u7684\u306a\u85ac\u5264\u3067\u3059\u3002\u814e\u81d3\u306e\u5c3f\u7d30\u7ba1\u3067\u7cd6\u304c\u518d\u5438\u53ce\u3055\u308c\u308b\u306e\u3092\u963b\u5bb3\u3057\u3001<strong>\u4f59\u5206\u306a\u7cd6\u3092\u5c3f\u304b\u3089\u6392\u6cc4\u3055\u305b\u308b<\/strong>\u3068\u3044\u3046\u72ec\u7279\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6301\u3061\u307e\u3059\u30021\u65e5\u3042\u305f\u308a\u7d0470\u301c80g\u306e\u7cd6\u3092\u5c3f\u304b\u3089\u6392\u51fa\u3059\u308b\u305f\u3081\u3001\u30ab\u30ed\u30ea\u30fc\u3067\u3044\u3046\u3068\u7d04300kcal\u3092\u300c\u5782\u308c\u6d41\u3057\u300d\u306b\u3059\u308b\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u3001SGLT2\u963b\u5bb3\u85ac\u306e\u771f\u306e\u4fa1\u5024\u306f\u3001\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u305d\u306e\u3082\u306e\u3088\u308a\u3082\u3001<strong>\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6291\u5236\u30fb\u814e\u6a5f\u80fd\u4fdd\u8b77\u30fb\u5fc3\u4e0d\u5168\u4e88\u9632<\/strong>\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3060\u3051\u3067\u306f\u8aac\u660e\u3067\u304d\u306a\u3044\u72ec\u7acb\u3057\u305f\u52b9\u679c\u3067\u3042\u308a\u3001\u300c\u7cd6\u5c3f\u75c5\u85ac\u300d\u3068\u3044\u3046\u67a0\u3092\u8d85\u3048\u3066\u5fc3\u81d3\u75c5\u3084\u814e\u81d3\u75c5\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3082\u4f7f\u308f\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><!-- ===== \u30a8\u30d3\u30c7\u30f3\u30b9\u30dc\u30c3\u30af\u30b9\uff08\u7dd1\uff09 ===== --><\/p>\n<div style=\"background:#e8f5e9; border-left:6px solid #388e3c; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#1b5e20; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aEMPA-REG OUTCOME\u8a66\u9a13<\/p>\n<p style=\"margin:0; line-height:1.8;\">\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u30442\u578b\u7cd6\u5c3f\u75c5\u60a3\u80057,020\u540d\u3092\u5bfe\u8c61\u306b\u3057\u305f\u5927\u898f\u6a21\u8a66\u9a13\u3002\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08SGLT2\u963b\u5bb3\u85ac\uff09\u7fa4\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001<strong>\u5fc3\u8840\u7ba1\u6b7b\u304c38%\u6e1b\u5c11\u3001\u5168\u6b7b\u4ea1\u304c32%\u6e1b\u5c11\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u304c35%\u6e1b\u5c11<\/strong>\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u814e\u6a5f\u80fd\u89e3\u6790\u3067\u306f\u3001<strong>\u9855\u6027\u814e\u75c7\u3078\u306e\u9032\u884c\u304c39%\u6e1b\u5c11\u3001\u900f\u6790\u5c0e\u5165\u304c55%\u6e1b\u5c11<\/strong>\u3068\u3044\u3046\u885d\u6483\u7684\u306a\u7d50\u679c\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08Zinman B et al. NEJM 2015; Wanner C et al. NEJM 2016\uff09\u3002<\/p>\n<\/div>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">SGLT2\u963b\u5bb3\u85ac\u304c\u5411\u3044\u3066\u3044\u308b\u65b9<\/h3>\n<ul>\n<li>\u5fc3\u4e0d\u5168\u306e\u65e2\u5f80\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u65b9<\/li>\n<li>\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u3092\u4f75\u767a\u3057\u3066\u3044\u308b\u65b9<\/li>\n<li>\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u6897\u585e\u306e\u65e2\u5f80\u304c\u3042\u308b\u65b9<\/li>\n<li>\u80a5\u6e80\u3067\u4f53\u91cd\u3092\u6e1b\u3089\u3057\u305f\u3044\u65b9\uff08116\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u5e73\u57471.79kg\u6e1b\u91cf\u3001Cheong AJY et al. Obesity 2022\uff09<\/li>\n<li>\u8840\u5727\u304c\u9ad8\u3081\u306e\u65b9\uff08SGLT2\u963b\u5bb3\u85ac\u306b\u306f\u964d\u5727\u52b9\u679c\u3082\u3042\u308a\uff09<\/li>\n<\/ul>\n<p><!-- ===== \u8b66\u544a\u30dc\u30c3\u30af\u30b9\uff08\u30aa\u30ec\u30f3\u30b8\uff09 ===== --><\/p>\n<div style=\"background:#fff3e0; border-left:6px solid #e65100; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#bf360c; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">SGLT2\u963b\u5bb3\u85ac\u306e\u6ce8\u610f\u70b9<\/p>\n<ul style=\"margin:6px 0 0 20px; line-height:1.8;\">\n<li><strong>\u8131\u6c34<\/strong>\uff1a\u5c3f\u91cf\u304c\u5897\u3048\u308b\u305f\u3081\u3001\u3053\u307e\u3081\u306a\u6c34\u5206\u88dc\u7d66\u304c\u5fc5\u9808\uff08\u7279\u306b\u590f\u5834\u30fb\u9ad8\u9f62\u8005\uff09<\/li>\n<li><strong>\u5c3f\u8def\u30fb\u6027\u5668\u611f\u67d3\u75c7<\/strong>\uff1a\u7cd6\u304c\u5c3f\u306b\u51fa\u308b\u305f\u3081\u3001\u5973\u6027\u3067\u983b\u5ea6\u304c\u3084\u3084\u5897\u52a0<\/li>\n<li><strong>\u75e9\u305b\u578b\u30fb\u9ad8\u9f62\u8005\u3067\u306f\u614e\u91cd\u306b<\/strong>\uff1a\u904e\u5ea6\u306e\u4f53\u91cd\u6e1b\u5c11\u30fb\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\uff08\u7b4b\u8089\u91cf\u4f4e\u4e0b\uff09\u306e\u30ea\u30b9\u30af<\/li>\n<li><strong>\u30b7\u30c3\u30af\u30c7\u30a4\u306b\u306f\u4f11\u85ac<\/strong>\uff1a\u767a\u71b1\u30fb\u4e0b\u75e2\u30fb\u8131\u6c34\u6642\u306f\u4e00\u6642\u4e2d\u6b62<\/li>\n<li><strong>\u6b63\u5e38\u8840\u7cd6\u30b1\u30c8\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9<\/strong>\uff1a\u7a00\u3060\u304c\u91cd\u7be4\u3002\u8840\u7cd6\u5024\u304c\u6b63\u5e38\u3067\u3082\u8d77\u304d\u3046\u308b<\/li>\n<\/ul>\n<\/div>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u2500\u8840\u7cd6\u30fb\u4f53\u91cd\u30fb\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u540c\u6642\u306b\u6539\u5584<\/h2>\n<p>GLP-1\uff08Glucagon-Like Peptide-1\uff09\u306f\u3001\u98df\u4e8b\u3092\u3059\u308b\u3068\u5c0f\u8178\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30a4\u30f3\u30af\u30ec\u30c1\u30f3\u3068\u3044\u3046\u6d88\u5316\u7ba1\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u7a2e\u3067\u3059\u3002GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001<strong>\u8840\u7cd6\u5024\u304c\u9ad8\u3044\u6642\u3060\u3051\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032<\/strong>\u3059\u308b\u3068\u3044\u3046\u753b\u671f\u7684\u306a\u4f5c\u7528\u3092\u6301\u3061\u3001\u4f4e\u8840\u7cd6\u3092\u8d77\u3053\u3057\u306b\u304f\u3044\u85ac\u5264\u3067\u3059\u3002\u307e\u305f\u3001\u8133\u306e\u98df\u6b32\u4e2d\u67a2\u306b\u50cd\u304d\u304b\u3051\u3066\u98df\u6b32\u3092\u6291\u3048\u3001\u80c3\u306e\u52d5\u304d\u3092\u3086\u3063\u304f\u308a\u306b\u3059\u308b\u3053\u3068\u3067\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3082\u767a\u63ee\u3057\u307e\u3059\u3002<\/p>\n<p>\u6ce8\u5c04\u85ac\u3068\u3057\u3066\u767b\u5834\u3057\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u306f<strong>\u7d4c\u53e3\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff08\u30ea\u30d9\u30eb\u30b5\u30b9\u00ae\uff09<\/strong>\u3068\u3044\u3046\u98f2\u307f\u85ac\u3082\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u6ce8\u5c04\u304c\u82e6\u624b\u306a\u65b9\u306b\u3082\u9078\u629e\u80a2\u304c\u5e83\u304c\u308a\u307e\u3057\u305f\u3002\u80a5\u6e80\u75c7\u6cbb\u7642\u85ac\uff08\u30a6\u30b4\u30fc\u30d3\u00ae\uff09\u3068\u3057\u3066\u3082\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><!-- ===== \u30a8\u30d3\u30c7\u30f3\u30b9\u30dc\u30c3\u30af\u30b9\uff08\u7dd1\uff09 ===== --><\/p>\n<div style=\"background:#e8f5e9; border-left:6px solid #388e3c; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#1b5e20; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aLEADER\u8a66\u9a13\uff08\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u306e\u5fc3\u8840\u7ba1\u4fdd\u8b77\uff09<\/p>\n<p style=\"margin:0; line-height:1.8;\">2\u578b\u7cd6\u5c3f\u75c5\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u80059,340\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8a66\u9a13\u3002\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\uff08GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff09\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001<strong>\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c13%\u6e1b\u5c11\u3001\u5fc3\u8840\u7ba1\u6b7b\u304c22%\u6e1b\u5c11\u3001\u5168\u6b7b\u4ea1\u304c15%\u6e1b\u5c11<\/strong>\u3057\u307e\u3057\u305f\u3002\u540c\u6642\u306bHbA1c\u3092\u7d040.4%\u4f4e\u4e0b\u3055\u305b\u3001\u4f53\u91cd\u3082\u5e73\u57472.3kg\u6e1b\u5c11\u3002GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u8840\u7cd6\u964d\u4e0b\u30fb\u4f53\u91cd\u6e1b\u5c11\u30fb\u5fc3\u8840\u7ba1\u4fdd\u8b77\u306e\u300c\u4e00\u77f3\u4e09\u9ce5\u300d\u52b9\u679c\u304c\u78ba\u7acb\u3057\u305f\u753b\u671f\u7684\u8a66\u9a13\u3067\u3059\uff08Marso SP et al. NEJM 2016\uff09\u3002<\/p>\n<\/div>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u304c\u5411\u3044\u3066\u3044\u308b\u65b9<\/h3>\n<ul>\n<li>\u80a5\u6e80\u3092\u4f34\u3046\u7cd6\u5c3f\u75c5\u3067\u3001\u5f37\u3044\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u671f\u5f85\u3057\u305f\u3044\u65b9<\/li>\n<li>\u98df\u4e8b\u91cf\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u96e3\u3057\u3044\u65b9\uff08\u98df\u6b32\u6291\u5236\u52b9\u679c\uff09<\/li>\n<li>\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u6897\u585e\u306e\u65e2\u5f80\u304c\u3042\u308b\u65b9<\/li>\n<li>\u4f4e\u8840\u7cd6\u304c\u6016\u3044\u65b9\uff08GLP-1\u5358\u72ec\u3067\u306f\u4f4e\u8840\u7cd6\u3092\u307b\u307c\u8d77\u3053\u3055\u306a\u3044\uff09<\/li>\n<\/ul>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u75c5\u614b\u5225\u306e\u85ac\u5264\u9078\u629e\u2500\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0<\/h2>\n<p>\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u306e\u300c2\u578b\u7cd6\u5c3f\u75c5\u306e\u85ac\u7269\u7642\u6cd5\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u300d\uff082022\u5e74\uff09\u3067\u306f\u3001\u6b21\u306e\u89b3\u70b9\u304b\u3089\u85ac\u5264\u3092\u9078\u3073\u307e\u3059\u3002\u5b9f\u969b\u306e\u8a3a\u7642\u3067\u306f\u3001\u3053\u308c\u3089\u3092\u7dcf\u5408\u7684\u306b\u7d44\u307f\u5408\u308f\u305b\u3066\u6700\u9069\u306a\u51e6\u65b9\u3092\u691c\u8a0e\u3057\u307e\u3059\u3002<\/p>\n<table style=\"width:100%; border-collapse:collapse; margin:20px 0;\">\n<thead>\n<tr style=\"background:#00796b; color:#fff;\">\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u75c5\u614b\u30fb\u60a3\u8005\u80cc\u666f<\/th>\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u512a\u5148\u3055\u308c\u3084\u3059\u3044\u85ac\u5264<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u80a5\u6e80\u578b\uff08BMI 25\u4ee5\u4e0a\uff09\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u4e3b\u4f53<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3001SGLT2\u963b\u5bb3\u85ac\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u75e9\u305b\u578b\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4f4e\u4e0b\u4e3b\u4f53<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">DPP-4\u963b\u5bb3\u85ac\u3001\u30b0\u30ea\u30cb\u30c9\u85ac\u3001\u5c11\u91cfSU\u85ac<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u5fc3\u4e0d\u5168\u65e2\u5f80\u30fb\u5fc3\u4e0d\u5168\u30ea\u30b9\u30af\u9ad8<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">SGLT2\u963b\u5bb3\u85ac\uff08\u7b2c\u4e00\u9078\u629e\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>CKD\uff08\u6162\u6027\u814e\u81d3\u75c5\uff09\u5408\u4f75<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">SGLT2\u963b\u5bb3\u85ac\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\u65e2\u5f80<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3001SGLT2\u963b\u5bb3\u85ac<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u9ad8\u9f62\u8005\uff0875\u6b73\u4ee5\u4e0a\uff09\u30fb\u30d5\u30ec\u30a4\u30eb<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">DPP-4\u963b\u5bb3\u85ac\uff08\u4f4e\u8840\u7cd6\u30ea\u30b9\u30af\u5c11\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u98df\u5f8c\u9ad8\u8840\u7cd6\u304c\u4e3b\u4f53<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u03b1-\u30b0\u30eb\u30b3\u30b7\u30c0\u30fc\u30bc\u963b\u5bb3\u85ac\u3001\u30b0\u30ea\u30cb\u30c9\u85ac<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><!-- ===== \u30dd\u30a4\u30f3\u30c8\u30dc\u30c3\u30af\u30b9\uff08\u9752\uff09 ===== --><\/p>\n<div style=\"background:#e3f2fd; border-left:6px solid #1976d2; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#0d47a1; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u540c\u3058\u300c\u7cd6\u5c3f\u75c5\u300d\u3067\u3082\u85ac\u306f\u4e00\u4eba\u3072\u3068\u308a\u9055\u3046<\/p>\n<p style=\"margin:0; line-height:1.8;\">\u4ee5\u524d\u306f\u300c\u307e\u305a\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3001\u52b9\u304b\u306a\u3051\u308c\u3070SU\u85ac\u3092\u8ffd\u52a0\u300d\u3068\u3044\u3046\u753b\u4e00\u7684\u306a\u6cbb\u7642\u304c\u4e3b\u6d41\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u73fe\u5728\u306f\u3001\u60a3\u8005\u3055\u3093\u306e<strong>\u4f53\u578b\u3001\u5e74\u9f62\u3001\u814e\u6a5f\u80fd\u3001\u5fc3\u81d3\u306e\u72b6\u614b\u3001\u751f\u6d3b\u30ea\u30ba\u30e0\u3001\u7d4c\u6e08\u72b6\u6cc1<\/strong>\u306a\u3069\u3092\u7dcf\u5408\u7684\u306b\u8003\u616e\u3057\u3066\u3001\u4e00\u4eba\u3072\u3068\u308a\u306b\u5408\u3063\u305f\u85ac\u3092\u9078\u3076\u6642\u4ee3\u3067\u3059\u3002<strong>\u3053\u308c\u304c\u300c\u500b\u5225\u5316\u533b\u7642\u300d\u306e\u672c\u8cea<\/strong>\u3067\u3042\u308a\u3001\u540c\u3058\u7cd6\u5c3f\u75c5\u306e\u8a3a\u65ad\u3067\u3082\u3001\u51e6\u65b9\u3055\u308c\u308b\u85ac\u306f\u60a3\u8005\u3055\u3093\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">CGM\uff08\u30ea\u30d6\u30ec\uff09\u306b\u3088\u308b\u500b\u5225\u5316\u6cbb\u7642\u2500\u5f53\u9662\u306e\u7279\u9577<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u3092\u5927\u304d\u304f\u5909\u3048\u305f\u3082\u3046\u4e00\u3064\u306e\u9769\u547d\u304c\u3001<strong>CGM\uff08Continuous Glucose Monitoring\u3001\u6301\u7d9a\u8840\u7cd6\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff09<\/strong>\u3067\u3059\u3002\u4ee3\u8868\u7684\u306aFreeStyle\u30ea\u30d6\u30ec\u306f\u3001\u4e0a\u8155\u306b\u88c5\u7740\u3059\u308b500\u5186\u7389\u5927\u306e\u30bb\u30f3\u30b5\u30fc\u304c\u300124\u6642\u9593\u8840\u7cd6\u5024\u3092\u9023\u7d9a\u6e2c\u5b9a\u3057\u307e\u3059\u3002\u30b9\u30de\u30fc\u30c8\u30d5\u30a9\u30f3\u3084\u5c02\u7528\u30ea\u30fc\u30c0\u30fc\u3067\u3001\u3044\u3064\u3067\u3082\u81ea\u5206\u306e\u8840\u7cd6\u5024\u3068\u5909\u52d5\u30d1\u30bf\u30fc\u30f3\u3092\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u5f93\u6765\u306e\u8840\u7cd6\u7ba1\u7406\u306f\u3001<strong>HbA1c\uff08\u904e\u53bb1\u301c2\u30f6\u6708\u306e\u5e73\u5747\u8840\u7cd6\uff09<\/strong>\u3068<strong>\u6307\u5148\u7a7f\u523a\u306b\u3088\u308b\u81ea\u5df1\u6e2c\u5b9a\uff08SMBG\u3001\u77ac\u9593\u5024\uff09<\/strong>\u306b\u983c\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057HbA1c\u306f\u300c\u5e73\u5747\u5024\u300d\u3067\u3057\u304b\u306a\u304f\u3001<strong>\u98df\u5f8c\u306e\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u3084\u591c\u9593\u4f4e\u8840\u7cd6\u306a\u3069\u3001\u5b9f\u969b\u306e\u8840\u7cd6\u5909\u52d5\u3092\u898b\u9003\u3057\u3066\u3057\u307e\u3046<\/strong>\u3068\u3044\u3046\u5927\u304d\u306a\u6b20\u70b9\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n<p><!-- ===== \u30e1\u30ab\u30cb\u30ba\u30e0\u56f3\u89e3\uff08\u7d2b\uff09 ===== --><\/p>\n<div style=\"background:#f3e5f5; border-left:6px solid #7b1fa2; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#4a148c; font-weight:bold; margin:0 0 14px 0; font-size:1.05em;\">CGM\u3067\u308f\u304b\u308b4\u3064\u306e\u300c\u898b\u3048\u306a\u304b\u3063\u305f\u8840\u7cd6\u300d<\/p>\n<table style=\"width:100%; border-collapse:collapse; margin:0;\">\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">1<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u98df\u5f8c\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\uff08Time Above Range\uff09<\/strong><br \/>HbA1c\uff08\u5e73\u5747\u5024\uff09\u304c\u540c\u3058\u3067\u3082\u3001\u98df\u5f8c\u306b<strong>180mg\/dL\u3092\u8d85\u3048\u308b\u6642\u9593\uff08Time Above Range\uff09<\/strong>\u304c\u9577\u3044\u4eba\u3068\u77ed\u3044\u4eba\u3067\u306f\u3001\u8840\u7ba1\u3078\u306e\u8ca0\u62c5\u304c\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002\u56fd\u969b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\uff08Battelino T et al. Diabetes Care 2019\uff09\u3067\u306f\u3001\u76ee\u6a19\u8840\u7cd6\u7bc4\u56f2\uff0870\u301c180mg\/dL\uff09\u5185\u306b\u5165\u3063\u3066\u3044\u308b\u6642\u9593\u306e\u5272\u5408\uff08Time in Range, TIR\uff09\u3092<strong>70%\u4ee5\u4e0a<\/strong>\u3068\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u300c\u898b\u3048\u306a\u3044\u9ad8\u8840\u7cd6\u300d\u3092\u53ef\u8996\u5316\u3067\u304d\u308b\u3053\u3068\u304cCGM\u306e\u6700\u5927\u306e\u4fa1\u5024\u3067\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">2<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u591c\u9593\u4f4e\u8840\u7cd6<\/strong><br \/>\u5c31\u5bdd\u4e2d\u306e\u4f4e\u8840\u7cd6\uff08\u7279\u306b\u9ad8\u9f62\u8005\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u4f7f\u7528\u8005\uff09\u306f\u81ea\u899a\u75c7\u72b6\u304c\u306a\u304f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u5f15\u304d\u91d1\u306b\u306a\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">3<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u8840\u7cd6\u5909\u52d5\u306e\u5927\u304d\u3055\uff08\u8840\u7cd6\u5909\u52d5\u6027\uff09<\/strong><br \/>\u5e73\u5747\u5024\u304c\u540c\u3058\u3067\u3082\u3001\u5909\u52d5\u304c\u5927\u304d\u3044\u4eba\u307b\u3069\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u5f37\u304f\u3001\u5408\u4f75\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:6px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">4<\/span><\/td>\n<td style=\"vertical-align:top; padding:6px 0;\"><strong>\u98df\u54c1\u30fb\u904b\u52d5\u3054\u3068\u306e\u500b\u4eba\u53cd\u5fdc<\/strong><br \/>\u300c\u767d\u7c73\u3067\u3082\u3053\u306e\u4eba\u306f\u8840\u7cd6\u304c\u4e0a\u304c\u3089\u306a\u3044\u300d\u300c\u3053\u306e\u4eba\u306f\u30d1\u30f3\u3088\u308a\u854e\u9ea6\u3067\u4e0a\u304c\u308b\u300d\u3068\u3044\u3046\u500b\u5225\u30d1\u30bf\u30fc\u30f3\u304c\u53ef\u8996\u5316\u3067\u304d\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/table>\n<\/div>\n<p><!-- ===== \u30a8\u30d3\u30c7\u30f3\u30b9\u30dc\u30c3\u30af\u30b9\uff08\u7dd1\uff09 ===== --><\/p>\n<div style=\"background:#e8f5e9; border-left:6px solid #388e3c; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#1b5e20; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aCGM\u306fHbA1c\u3092\u4e0b\u3052\u308b<\/p>\n<p style=\"margin:0; line-height:1.8;\">\u591a\u65bd\u8a2d\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u591a\u56de\u6ce8\u5c04\u3092\u884c\u3046\u6210\u4eba\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u5bfe\u3057\u3066CGM\u3092\u5c0e\u5165\u3057\u305f\u7fa4\u306f\u3001\u5f93\u6765\u306e\u6307\u5148\u6e2c\u5b9a\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001<strong>24\u9031\u9593\u3067HbA1c\u304c\u6709\u610f\u306b\u4f4e\u4e0b<\/strong>\u3057\u307e\u3057\u305f\uff08Beck RW et al. Ann Intern Med 2017 [DIAMOND\u8a66\u9a13T2D]; Martens T et al. JAMA 2021 [MOBILE\u8a66\u9a13]\uff09\u3002\u307e\u305f\u57fa\u790e\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u307f\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u3082\u540c\u69d8\u306e\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">\u5f53\u9662\u306eCGM\u6d3b\u7528\u65b9\u91dd<\/h3>\n<p>\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u65b9\u306bCGM\u3092\u7a4d\u6975\u7684\u306b\u6d3b\u7528\u3057\u3066\u3044\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u6cbb\u7642\u4e2d\u306e\u60a3\u8005\u3055\u3093<\/strong>\uff08\u4fdd\u967a\u9069\u7528\u3042\u308a\uff09\uff1a\u8840\u7cd6\u5909\u52d5\u306e\u6700\u9069\u5316\u3001\u4f4e\u8840\u7cd6\u56de\u907f<\/li>\n<li><strong>\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u96e3\u3057\u3044\u65b9<\/strong>\uff1a\u5909\u52d5\u30d1\u30bf\u30fc\u30f3\u304b\u3089\u539f\u56e0\u3092\u7279\u5b9a<\/li>\n<li><strong>\u98df\u4e8b\u7642\u6cd5\u306e\u52b9\u679c\u3092\u5b9f\u611f\u3057\u305f\u3044\u65b9<\/strong>\uff08\u81ea\u8cbb\u30fb\u77ed\u671f\u88c5\u7740\uff09\uff1a\u3069\u306e\u98df\u54c1\u3067\u3069\u308c\u3060\u3051\u8840\u7cd6\u304c\u4e0a\u304c\u308b\u304b\u3092\u53ef\u8996\u5316<\/li>\n<li><strong>\u5883\u754c\u578b\u7cd6\u5c3f\u75c5\u30fb\u4e88\u5099\u8ecd\u306e\u65b9<\/strong>\uff08\u81ea\u8cbb\u30fb\u77ed\u671f\u88c5\u7740\uff09\uff1a\u767a\u75c7\u4e88\u9632\u306e\u305f\u3081\u306e\u884c\u52d5\u5909\u5bb9\u30c4\u30fc\u30eb<\/li>\n<\/ul>\n<p>\u9662\u9577\u4e94\u85e4\u306f\u3001<strong>CGM\u30c7\u30fc\u30bf\u3092\u60a3\u8005\u3055\u3093\u3068\u4e00\u7dd2\u306b\u89e3\u6790\u3057\u3001\u98df\u4e8b\u30fb\u904b\u52d5\u30fb\u85ac\u5264\u306e\u8abf\u6574\u3092\u500b\u5225\u5316\u3059\u308b\u8a3a\u7642<\/strong>\u3092\u91cd\u8996\u3057\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u6570\u5024\u3092\u898b\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u306a\u305c\u3053\u306e\u6642\u9593\u306b\u8840\u7cd6\u304c\u4e0a\u304c\u3063\u305f\u306e\u304b\u300d\u3092\u60a3\u8005\u3055\u3093\u3068\u4e00\u7dd2\u306b\u8003\u3048\u308b\u3053\u3068\u3067\u3001<strong>\u7d0d\u5f97\u611f\u306e\u3042\u308b\u884c\u52d5\u5909\u5bb9<\/strong>\u304c\u751f\u307e\u308c\u307e\u3059\u3002<\/p>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u7cd6\u5c3f\u75c5\u85ac\u306f\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u304b\uff1f \u2500 Geroscience\uff08\u8001\u5316\u533b\u79d1\u5b66\uff09\u306e\u8996\u70b9<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\u3092\u8a9e\u308b\u3046\u3048\u3067\u3001\u8fd1\u5e74\u898b\u9003\u305b\u306a\u3044\u30c6\u30fc\u30de\u304c\u300c<strong>\u7cd6\u5c3f\u75c5\u85ac\u304c\u8001\u5316\u305d\u306e\u3082\u306e\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027<\/strong>\u300d\u3067\u3059\u3002\u3053\u308c\u306f<strong>Geroscience\uff08\u8001\u5316\u533b\u79d1\u5b66\uff09<\/strong>\u3068\u547c\u3070\u308c\u308b\u5b66\u554f\u9818\u57df\u306e\u6838\u5fc3\u7684\u306a\u554f\u3044\u3067\u3059\u3002\u300c\u7cd6\u5c3f\u75c5\u30fb\u5fc3\u8840\u7ba1\u75c5\u30fb\u304c\u3093\u30fb\u8a8d\u77e5\u75c7\u306f\u3059\u3079\u3066\u52a0\u9f62\u306b\u4f34\u3063\u3066\u5897\u3048\u308b\u75c5\u6c17\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306b\u5171\u901a\u3059\u308b&#8221;\u8001\u5316&#8221;\u3068\u3044\u3046\u571f\u53f0\u305d\u306e\u3082\u306e\u306b\u85ac\u3067\u4ecb\u5165\u3067\u304d\u308c\u3070\u3001\u8907\u6570\u306e\u75c5\u6c17\u3092\u540c\u6642\u306b\u6e1b\u3089\u305b\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u300d\u2500\u3053\u306e\u767a\u60f3\u304c\u3001\u3044\u307e\u4e16\u754c\u306e\u8001\u5e74\u533b\u5b66\u306e\u6700\u524d\u7dda\u3067\u691c\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30a2\u30e1\u30ea\u30ab\u56fd\u7acb\u8001\u5316\u7814\u7a76\u6240\uff08NIA\uff09\u306f\u3001\u5bff\u547d\u5ef6\u4f38\u30fb\u5065\u5eb7\u5bff\u547d\u5ef6\u4f38\u52b9\u679c\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u85ac\u5264\u3092\u3001<strong>\u907a\u4f1d\u7684\u306b\u591a\u69d8\u306a\u30de\u30a6\u30b9<\/strong>\u3092\u7528\u3044\u3066<strong>\u8907\u6570\u306e\u72ec\u7acb\u3057\u305f\u65bd\u8a2d\u3067\u540c\u6642\u306b\u691c\u8a3c\u3059\u308b\u300cInterventions Testing Program\uff08ITP\uff09\u300d<\/strong>\u3068\u3044\u3046\u67a0\u7d44\u307f\u30922003\u5e74\u304b\u3089\u904b\u55b6\u3057\u3066\u3044\u307e\u3059\u3002\u5358\u4e00\u65bd\u8a2d\u306e\u7d50\u679c\u306b\u5de6\u53f3\u3055\u308c\u305a\u3001\u53b3\u683c\u306a\u6a19\u6e96\u4f5c\u696d\u624b\u9806\uff08SOP\uff09\u306e\u3082\u3068\u3067\u518d\u73fe\u6027\u3092\u78ba\u8a8d\u3059\u308b\u3001\u8001\u5316\u4ecb\u5165\u7814\u7a76\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3067\u3059\u3002<\/p>\n<p><!-- ===== \u30a8\u30d3\u30c7\u30f3\u30b9\u30dc\u30c3\u30af\u30b9\uff08\u7dd1\uff09 ===== --><\/p>\n<div style=\"background:#e8f5e9; border-left:6px solid #388e3c; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#1b5e20; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aNIA-ITP\u3067\u5bff\u547d\u5ef6\u9577\u304c\u78ba\u8a8d\u3055\u308c\u305f\u85ac\u5264<\/p>\n<p style=\"margin:0 0 10px 0; line-height:1.8;\">NIA-ITP\u306b\u304a\u3044\u3066\u3001\u30de\u30a6\u30b9\u3067\u6709\u610f\u306b\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4e3b\u306a\u85ac\u5264\u306f\u3001<strong>\u30e9\u30d1\u30de\u30a4\u30b7\u30f3<\/strong>\uff08Harrison DE et al. Nature 2009\uff09\u3001<strong>\u30a2\u30ab\u30eb\u30dc\u30fc\u30b9<\/strong>\uff08Harrison DE et al. Aging Cell 2014\uff09\u3001<strong>17-\u03b1-\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb<\/strong>\uff08Harrison DE et al. Aging Cell 2014\uff09\u3001<strong>\u30a2\u30b9\u30d4\u30ea\u30f3<\/strong>\uff08Strong R et al. Aging Cell 2008\uff09\u3001<strong>\u30ce\u30eb\u30b8\u30d2\u30c9\u30ed\u30b0\u30a2\u30a4\u30a2\u30ec\u30c1\u30f3\u9178\uff08NDGA\uff09<\/strong>\uff08Strong R et al. Aging Cell 2008\uff09\u3067\u3059\u3002\u3053\u306e\u3046\u3061\u3001<strong>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3067\u3042\u308b\u300c\u30a2\u30ab\u30eb\u30dc\u30fc\u30b9\u300d<\/strong>\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u70b9\u306f\u81e8\u5e8a\u7684\u306b\u3082\u5927\u5909\u8208\u5473\u6df1\u3044\u7d50\u679c\u3067\u3059\u3002<\/p>\n<p style=\"margin:0; line-height:1.8;\">ITP\u4ee5\u5916\u306e\u7814\u7a76\u3067\u306f\u3001<strong>\u30e1\u30c8\u30db\u30eb\u30df\u30f3<\/strong>\uff08Martin-Montalvo A et al. Nat Commun 2013, \u30de\u30a6\u30b9\u3067\u5065\u5eb7\u5bff\u547d\u30fb\u5bff\u547d\u5ef6\u9577\uff09\u3001<strong>\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb<\/strong>\uff08\u9ad8\u8102\u80aa\u98df\u30de\u30a6\u30b9\u3067\u5bff\u547d\u5ef6\u9577\u3001Baur JA et al. Nature 2006\uff09\u3001<strong>ACEi\/ARB<\/strong>\u3082\u5019\u88dc\u85ac\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u3066\u3044\u307e\u3059\uff08Newman JC et al. J Gerontol A Biol Sci Med Sci 2016\uff09\u3002<\/p>\n<\/div>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u3068\u5bff\u547d\u30fb\u5065\u5eb7\u5bff\u547d<\/h3>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u3046\u3061\u3001<strong>\u30e1\u30c8\u30db\u30eb\u30df\u30f3<\/strong>\u306f\u6297\u8001\u5316\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u6700\u3082\u591a\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u85ac\u5264\u3067\u3059\u3002\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u306f\u3001<strong>AMPK\uff08\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u9175\u7d20\uff09\u306e\u6d3b\u6027\u5316<\/strong>\u3001<strong>mTOR\uff08\u7d30\u80de\u6210\u9577\u30b7\u30b0\u30ca\u30eb\uff09\u306e\u6291\u5236<\/strong>\u3001<strong>IGF-1\u30b7\u30b0\u30ca\u30eb\u306e\u4f4e\u4e0b<\/strong>\u3001<strong>\u6162\u6027\u708e\u75c7\uff08\u8001\u5316\u95a2\u9023\u5206\u6ccc\u8868\u73fe\u578b\u3001SASP\uff09\u306e\u6291\u5236<\/strong>\u3068\u3044\u3063\u305f\u3001\u8001\u5316\u306e\u57fa\u672c\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5e83\u304f\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><!-- ===== \u30dd\u30a4\u30f3\u30c8\u30dc\u30c3\u30af\u30b9\uff08\u9752\uff09 ===== --><\/p>\n<div style=\"background:#e3f2fd; border-left:6px solid #1976d2; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#0d47a1; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">TAME\u8a66\u9a13\uff08Targeting Aging with Metformin\uff09<\/p>\n<p style=\"margin:0; line-height:1.8;\">\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u300165\u6b73\u4ee5\u4e0a\u306e\u7d043,000\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u304c<strong>\u5fc3\u8840\u7ba1\u75c5\u30fb\u304c\u3093\u30fb\u8a8d\u77e5\u75c7\u30fb\u7cd6\u5c3f\u75c5\u30fb\u6b7b\u4ea1<\/strong>\u3068\u3044\u3063\u305f\u8907\u6570\u306e\u52a0\u9f62\u95a2\u9023\u75be\u60a3\u306e\u767a\u75c7\u3092\u540c\u6642\u306b\u9045\u3089\u305b\u308b\u304b\u3092\u691c\u8a3c\u3059\u308b\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u300cTAME\u8a66\u9a13\u300d\u304c\u8a08\u753b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f<strong>\u300c\u8001\u5316\u300d\u305d\u306e\u3082\u306e\u3092FDA\uff08\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff09\u306b\u75be\u60a3\u3068\u3057\u3066\u8a8d\u3081\u3066\u3082\u3089\u3046<\/strong>\u3068\u3044\u3046\u6b74\u53f2\u7684\u610f\u7fa9\u3092\u6301\u3064\u8a66\u9a13\u3067\u3059\uff08Newman JC et al. J Gerontol A Biol Sci Med Sci 2016\uff09\u3002<\/p>\n<\/div>\n<p>\u305f\u3060\u3057\u91cd\u8981\u306a\u306e\u306f\u3001\u3053\u3046\u3057\u305f\u6297\u8001\u5316\u52b9\u679c\u306f<strong>\u3042\u304f\u307e\u3067\u7814\u7a76\u6bb5\u968e\u3067\u3042\u308a\u3001\u300c\u5065\u5eb7\u306a\u4eba\u304c\u82e5\u8fd4\u308a\u76ee\u7684\u3067\u7cd6\u5c3f\u75c5\u85ac\u3092\u670d\u7528\u3057\u3066\u3088\u3044\u300d\u3068\u3044\u3046\u8a71\u3067\u306f\u306a\u3044<\/strong>\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u9577\u671f\u89b3\u5bdf\u7814\u7a76\u3067\u306f\u3001\u77ed\u671f\u7684\u306b\u306f\u7cd6\u5c3f\u75c5\u3067\u306a\u3044\u5bfe\u7167\u7fa4\u3068\u540c\u7b49\u306e\u751f\u5b58\u3092\u793a\u3057\u305fBannister CA \u3089\u306e\u5831\u544a\uff08Diabetes Obes Metab 2014\uff09\u304c\u3042\u308b\u4e00\u65b9\u300120\u5e74\u8ffd\u8de1\u3057\u305fStevenson-Hoare J\u3089\u306e\u518d\u89e3\u6790\uff082023\uff09\u3067\u306f\u9577\u671f\u7684\u306b\u306f\u7cd6\u5c3f\u75c5\u7fa4\u306e\u751f\u5b58\u304c\u77ed\u304f\u306a\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u7d50\u679c\u306e\u89e3\u91c8\u306b\u306f\u614e\u91cd\u3055\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">SGLT2\u963b\u5bb3\u85ac\u304c\u5207\u308a\u62d3\u304f\u65b0\u3057\u3044\u53ef\u80fd\u6027<\/h3>\n<p>\u524d\u8ff0\u306eEMPA-REG OUTCOME\u8a66\u9a13\uff08Zinman B et al. NEJM 2015\uff09\u3067<strong>\u5fc3\u8840\u7ba1\u6b7b\u30fb\u5168\u6b7b\u4ea1\u306e\u6709\u610f\u306a\u4f4e\u4e0b<\/strong>\u304c\u793a\u3055\u308c\u305fSGLT2\u963b\u5bb3\u85ac\u306f\u3001\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3092\u8d85\u3048\u305f\u591a\u9762\u7684\u52b9\u679c\uff08\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u6a21\u5023\u3001\u814e\u4fdd\u8b77\u3001\u6297\u708e\u75c7\u3001\u5fc3\u4fdd\u8b77\uff09\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002Geroscience\u7814\u7a76\u8005\u306e\u9593\u3067\u3082\u3001SGLT2\u963b\u5bb3\u85ac\u306f<strong>\u6b21\u4e16\u4ee3\u306e\u6297\u8001\u5316\u5019\u88dc\u85ac<\/strong>\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><!-- ===== \u8b66\u544a\u30dc\u30c3\u30af\u30b9\uff08\u30aa\u30ec\u30f3\u30b8\uff09 ===== --><\/p>\n<div style=\"background:#fff3e0; border-left:6px solid #e65100; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#bf360c; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u8aa4\u89e3\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u3053\u3068<\/p>\n<p style=\"margin:0; line-height:1.8;\">\u300c\u7cd6\u5c3f\u75c5\u85ac\u304c\u5bff\u547d\u3092\u5ef6\u3070\u3059\u300d\u3068\u3044\u3046\u5831\u9053\u3084\u60c5\u5831\u304c\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u4e0a\u3067\u76ee\u7acb\u3061\u307e\u3059\u304c\u3001<strong>\u73fe\u6642\u70b9\u3067\u306f\u30d2\u30c8\u3067\u306e\u660e\u78ba\u306a\u6297\u8001\u5316\u52b9\u679c\u306f\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093<\/strong>\u3002\u5065\u5eb7\u306a\u65b9\u3078\u306e\u4e88\u9632\u6295\u4e0e\u3084\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u4e0d\u5341\u5206\u306a\u81ea\u5df1\u5224\u65ad\u306e\u5185\u670d\u306f\u3001\u526f\u4f5c\u7528\uff08\u4e73\u9178\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u3001\u30d3\u30bf\u30df\u30f3B12\u4f4e\u4e0b\u3001\u8131\u6c34\u306a\u3069\uff09\u306e\u30ea\u30b9\u30af\u3092\u8ca0\u3046\u3060\u3051\u3067\u3001\u30e1\u30ea\u30c3\u30c8\u304c\u4e0d\u660e\u78ba\u3067\u3059\u3002\u7cd6\u5c3f\u75c5\u3067\u306a\u3044\u65b9\u304c\u6297\u8001\u5316\u76ee\u7684\u3067\u670d\u7528\u3059\u308b\u3053\u3068\u306f\u73fe\u6642\u70b9\u3067\u63a8\u5968\u3055\u308c\u305a\u3001\u5fc5\u305a\u533b\u5e2b\u306e\u7ba1\u7406\u4e0b\u3067\u3001\u9069\u5fdc\u306b\u57fa\u3065\u3044\u305f\u51e6\u65b9\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<\/div>\n<p>\u9662\u9577\u4e94\u85e4\u306f\u3001<strong>\u7cd6\u5c3f\u75c5\u8a3a\u7642\u3068\u6297\u52a0\u9f62\u533b\u5b66\uff08\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\uff09\u306e\u4e21\u65b9\u3092\u5c02\u9580<\/strong>\u3068\u3057\u3066\u304a\u308a\u3001\u6700\u65b0\u306eGeroscience\u7814\u7a76\u306e\u77e5\u898b\u3092\u8e0f\u307e\u3048\u305f\u8a3a\u7642\u3092\u5fc3\u304c\u3051\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u3092\u304a\u6301\u3061\u306e\u65b9\u306b\u3068\u3063\u3066\u3001\u300c\u8840\u7cd6\u3092\u4e0b\u3052\u308b\u300d\u3060\u3051\u3067\u306a\u304f\u300c\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u300d\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u6700\u9069\u306a\u85ac\u5264\u9078\u629e\u3092\u4e00\u7dd2\u306b\u8003\u3048\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u5408\u4f75\u75c7\u306e\u65e9\u671f\u767a\u898b\u3068\u4e88\u9632\u2500\u300c\u4e09\u5927\u5408\u4f75\u75c7\u300d\u3068\u300c\u5927\u8840\u7ba1\u75c7\u300d<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u7d42\u76ee\u6a19\u306f\u3001<strong>\u5408\u4f75\u75c7\u3092\u9632\u3044\u3067\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068<\/strong>\u3067\u3059\u3002\u5408\u4f75\u75c7\u306f\u5927\u304d\u304f2\u3064\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">\u7d30\u5c0f\u8840\u7ba1\u75c7\uff08\u7cd6\u5c3f\u75c5\u4e09\u5927\u5408\u4f75\u75c7\uff09<\/h3>\n<table style=\"width:100%; border-collapse:collapse; margin:20px 0;\">\n<thead>\n<tr style=\"background:#00796b; color:#fff;\">\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u5408\u4f75\u75c7<\/th>\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u75c7\u72b6\u30fb\u4e88\u5f8c<\/th>\n<th style=\"padding:10px; border:1px solid #004d40; text-align:left;\">\u63a8\u5968\u691c\u67fb\u983b\u5ea6<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u7cd6\u5c3f\u75c5\u7db2\u819c\u75c7<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u5931\u660e\u306e\u4e3b\u8981\u539f\u56e0\u3002\u521d\u671f\u306f\u7121\u75c7\u72b6\u3002\u9032\u884c\u3059\u308b\u3068\u785d\u5b50\u4f53\u51fa\u8840\u30fb\u7db2\u819c\u5265\u96e2<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u773c\u79d1\u3067\u5e741\u56de\u4ee5\u4e0a\u306e\u773c\u5e95\u691c\u67fb<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u7cd6\u5c3f\u75c5\u814e\u75c7<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u65b0\u898f\u900f\u6790\u5c0e\u5165\u539f\u56e0\u306e\u7b2c1\u4f4d\u3002\u521d\u671f\u306f\u7121\u75c7\u72b6<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u5c3f\u30a2\u30eb\u30d6\u30df\u30f3\u30fbeGFR\u3092\u5e741\u301c2\u56de<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px; border:1px solid #b2dfdb; background:#f1f8f6;\"><strong>\u7cd6\u5c3f\u75c5\u795e\u7d4c\u969c\u5bb3<\/strong><\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u8db3\u306e\u3057\u3073\u308c\u30fb\u75db\u307f\u30fb\u611f\u899a\u4f4e\u4e0b\u3002\u8db3\u75c5\u5909\u30fb\u58ca\u75bd\u306e\u539f\u56e0<\/td>\n<td style=\"padding:10px; border:1px solid #b2dfdb;\">\u554f\u8a3a\u30fb\u30a2\u30ad\u30ec\u30b9\u8171\u53cd\u5c04\u30fb\u632f\u52d5\u899a\u3092\u5e741\u56de\u4ee5\u4e0a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 style=\"color:#00796b; border-bottom:3px solid #00796b; padding-bottom:6px; margin-top:30px;\">\u5927\u8840\u7ba1\u75c7\uff08\u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\uff09<\/h3>\n<p>\u7cd6\u5c3f\u75c5\u306e\u65b9\u3067\u306f\u3001\u975e\u7cd6\u5c3f\u75c5\u306e\u65b9\u3068\u6bd4\u8f03\u3057\u3066\u5927\u8840\u7ba1\u75c7\u306e\u30ea\u30b9\u30af\u304c\u5927\u5e45\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001102\u306e\u524d\u5411\u304d\u7814\u7a76\u30fb\u7d0470\u4e07\u4eba\u3092\u7d71\u5408\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08Emerging Risk Factors Collaboration, Lancet 2010\uff09\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b<strong>\u51a0\u52d5\u8108\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306f\u7d042\u500d\uff08HR 2.00\u300195%CI 1.83-2.19\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306f\u7d042.3\u500d\uff08HR 2.27\u300195%CI 1.95-2.65\uff09<\/strong>\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u306f\u300c\u52d5\u8108\u786c\u5316\u4fc3\u9032\u75c5\u300d\u3068\u3082\u8a00\u3048\u308b\u75c5\u6c17\u3067\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u8840\u5727\u30fb\u8102\u8cea\u30fb\u4f53\u91cd\u30fb\u7981\u7159<\/strong>\u3092\u540c\u6642\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p><!-- ===== \u91cd\u8981\u30dc\u30c3\u30af\u30b9\uff08\u8d64\uff09 ===== --><\/p>\n<div style=\"background:#ffebee; border-left:6px solid #c62828; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<p style=\"color:#b71c1c; font-weight:bold; margin:0 0 10px 0; font-size:1.05em;\">\u898b\u9003\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u30b5\u30a4\u30f3<\/p>\n<ul style=\"margin:6px 0 0 20px; line-height:1.8;\">\n<li>\u8996\u754c\u304c\u304b\u3059\u3080\u3001\u98db\u868a\u75c7\u304c\u5897\u3048\u305f \u2192 \u773c\u5e95\u51fa\u8840\u306e\u53ef\u80fd\u6027<\/li>\n<li>\u8db3\u5148\u306e\u3057\u3073\u308c\u3001\u611f\u899a\u4f4e\u4e0b\u3001\u50b7\u304c\u6cbb\u308a\u306b\u304f\u3044 \u2192 \u795e\u7d4c\u969c\u5bb3\u30fb\u8840\u6d41\u969c\u5bb3<\/li>\n<li>\u5c3f\u304c\u6ce1\u7acb\u3064 \u2192 \u30bf\u30f3\u30d1\u30af\u5c3f\uff08\u814e\u75c7\uff09\u306e\u53ef\u80fd\u6027<\/li>\n<li>\u968e\u6bb5\u3067\u606f\u5207\u308c\u3001\u80f8\u306e\u5727\u8feb\u611f \u2192 \u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u53ef\u80fd\u6027<\/li>\n<li>\u8db3\u304c\u51b7\u305f\u3044\u3001\u6b69\u304f\u3068\u3075\u304f\u3089\u306f\u304e\u304c\u75db\u3080 \u2192 \u672b\u68a2\u52d5\u8108\u75be\u60a3<\/li>\n<\/ul>\n<\/div>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u98df\u4e8b\u7642\u6cd5\u2500\u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f\u306e\u8003\u3048\u65b9<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u571f\u53f0\u306f\u3001\u3042\u304f\u307e\u3067<strong>\u98df\u4e8b\u7642\u6cd5<\/strong>\u3067\u3059\u3002\u3069\u3093\u306a\u306b\u512a\u308c\u305f\u85ac\u3092\u4f7f\u3063\u3066\u3082\u3001\u98df\u4e8b\u304c\u4e71\u308c\u3066\u3044\u3066\u306f\u52b9\u679c\u304c\u534a\u6e1b\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u300c\u53b3\u3057\u3044\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u300d\u300c\u7cd6\u8cea\u5b8c\u5168\u30ab\u30c3\u30c8\u300d\u300c\u4e00\u751f\u7d9a\u304f\u6211\u6162\u300d\u3068\u3044\u3063\u305f\u30a4\u30e1\u30fc\u30b8\u304b\u3089\u3001\u98df\u4e8b\u7642\u6cd5\u304c\u7d9a\u304b\u306a\u3044\u65b9\u306f\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u9662\u9577\u4e94\u85e4\u306e\u8457\u66f8<strong>\u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f\uff08\u30a2\u30b9\u30b3\u30e0\u30012024\u5e74\uff09<\/strong>\u3067\u306f\u3001\u7121\u7406\u306a\u304f\u7d9a\u3051\u3089\u308c\u308b\u5b9f\u8df5\u7684\u306a\u98df\u4e8b\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002\u4e2d\u6027\u8102\u80aa\u3084\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u6c17\u306b\u306a\u308b\u65b9\u3001\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\u306e\u9032\u884c\u3092\u9632\u304e\u305f\u3044\u65b9\u306b\u5411\u3051\u305f\u3001<strong>\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30b9\u30fc\u30d7\u30ec\u30b7\u30d4<\/strong>\u3092\u307e\u3068\u3081\u305f\u4e00\u518a\u3067\u3059\u3002<\/p>\n<div style=\"background:#fff; border:2px solid #00796b; border-radius:12px; padding:20px; margin:24px 0;\">\n<p style=\"color:#00796b; font-weight:bold; margin:0 0 12px 0; font-size:1.1em;\">\u672c\u66f8\u306e\u30dd\u30a4\u30f3\u30c8<\/p>\n<ul style=\"margin:0 0 0 20px; line-height:1.8;\">\n<li>\u5185\u81d3\u8102\u80aa\u3092\u6e1b\u3089\u3059\u305f\u3081\u306e\u5177\u4f53\u7684\u306a\u98df\u6750\u306e\u9078\u3073\u65b9<\/li>\n<li>\u4e2d\u6027\u8102\u80aa\u30fbLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4e0b\u3052\u308b\u30b9\u30fc\u30d7\u30ec\u30b7\u30d4<\/li>\n<li>\u5fd9\u3057\u3044\u65b9\u3067\u3082\u7d9a\u3051\u3089\u308c\u308b\u4f5c\u308a\u7f6e\u304d\u30fb\u6642\u77ed\u30e1\u30cb\u30e5\u30fc<\/li>\n<li>\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u6291\u3048\u308b\u300c\u98df\u3079\u308b\u9806\u756a\u300d<\/li>\n<li>\u533b\u5b66\u7684\u6839\u62e0\uff08\u30a8\u30d3\u30c7\u30f3\u30b9\uff09\u306b\u57fa\u3065\u304f\u6804\u990a\u5b66\u89e3\u8aac<\/li>\n<\/ul>\n<p style=\"margin:14px 0 0 0;\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089\uff1a<a href=\"https:\/\/amzn.asia\/d\/05aU1Ae8\" target=\"_blank\" rel=\"noopener\">\u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f\uff08Amazon\u3067\u898b\u308b\uff09<\/a><\/p>\n<\/div>\n<p>\u7cd6\u5c3f\u75c5\u306e\u98df\u4e8b\u7642\u6cd5\u3067\u306f\u3001\u300c<strong>\u4f55\u3092\u98df\u3079\u306a\u3044\u304b<\/strong>\u300d\u3060\u3051\u3067\u306a\u304f\u300c<strong>\u4f55\u3092\u512a\u5148\u7684\u306b\u98df\u3079\u308b\u304b<\/strong>\u300d\u3092\u8003\u3048\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002\u91ce\u83dc\u30fb\u6d77\u85fb\u30fb\u304d\u306e\u3053\u30fb\u5927\u8c46\u88fd\u54c1\u30fb\u9752\u9b5a\u3092\u4e2d\u5fc3\u306b\u3001\u826f\u8cea\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u98df\u7269\u7e4a\u7dad\u3092\u610f\u8b58\u7684\u306b\u3068\u308b\u3053\u3068\u3067\u3001\u81ea\u7136\u3068\u8840\u7cd6\u3068\u4f53\u91cd\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u4eca\u65e5\u304b\u3089\u5b9f\u8df5\u3067\u304d\u308b5\u3064\u306e\u884c\u52d5<\/h2>\n<p><!-- ===== \u30e1\u30ab\u30cb\u30ba\u30e0\u56f3\u89e3\uff08\u7d2b\uff09 ===== --><\/p>\n<div style=\"background:#f3e5f5; border-left:6px solid #7b1fa2; padding:18px 22px; margin:24px 0; border-radius:0 8px 8px 0;\">\n<table style=\"width:100%; border-collapse:collapse; margin:0;\">\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:8px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">1<\/span><\/td>\n<td style=\"vertical-align:top; padding:8px 0;\"><strong>\u85ac\u3092\u98f2\u307f\u5fd8\u308c\u305f\u3089\u5fc5\u305a\u533b\u5e2b\u306b\u76f8\u8ac7<\/strong><br \/>\u81ea\u5df1\u5224\u65ad\u3067\u306e\u4e2d\u65ad\u306f\u8840\u7cd6\u6025\u5909\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002\u98f2\u307f\u5fd8\u308c\u306e\u5bfe\u51e6\u6cd5\u3092\u4e3b\u6cbb\u533b\u3068\u5171\u6709\u3057\u307e\u3057\u3087\u3046\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:8px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">2<\/span><\/td>\n<td style=\"vertical-align:top; padding:8px 0;\"><strong>\u5e741\u56de\u306e\u5408\u4f75\u75c7\u30c1\u30a7\u30c3\u30af\u3092\u6b20\u304b\u3055\u306a\u3044<\/strong><br \/>\u773c\u5e95\u691c\u67fb\uff08\u773c\u79d1\uff09\u3001\u5c3f\u30a2\u30eb\u30d6\u30df\u30f3\uff08\u5185\u79d1\uff09\u3001\u8db3\u306e\u8a3a\u5bdf\uff08\u5185\u79d1\uff09\u3001\u5fc3\u96fb\u56f3\u30fb\u9838\u52d5\u8108\u30a8\u30b3\u30fc\uff08\u5185\u79d1\uff09\u3002\u75c7\u72b6\u304c\u306a\u304f\u3066\u3082\u691c\u67fb\u306f\u5fc5\u9808\u3067\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:8px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">3<\/span><\/td>\n<td style=\"vertical-align:top; padding:8px 0;\"><strong>\u98df\u5f8c\u306e\u8840\u7cd6\u5909\u52d5\u3092\u4e00\u5ea6\u306f\u898b\u3066\u307f\u308b<\/strong><br \/>CGM\u306e\u77ed\u671f\u88c5\u7740\uff082\u9031\u9593\uff09\u3067\u81ea\u5206\u306e\u8840\u7cd6\u30d1\u30bf\u30fc\u30f3\u3092\u53ef\u8996\u5316\u3002\u98df\u4e8b\u30fb\u904b\u52d5\u306e\u6539\u5584\u30dd\u30a4\u30f3\u30c8\u304c\u660e\u78ba\u306b\u306a\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:8px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">4<\/span><\/td>\n<td style=\"vertical-align:top; padding:8px 0;\"><strong>\u98df\u3079\u308b\u9806\u756a\u3092\u300c\u91ce\u83dc\u2192\u30bf\u30f3\u30d1\u30af\u8cea\u2192\u70ad\u6c34\u5316\u7269\u300d\u306b<\/strong><br \/>\u98df\u7269\u7e4a\u7dad\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5148\u306b\u98df\u3079\u308b\u3053\u3068\u3067\u3001\u98df\u5f8c\u8840\u7cd6\u306e\u4e0a\u6607\u3092\u7de9\u3084\u304b\u306b\u3067\u304d\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"width:40px; vertical-align:top; padding:8px 0;\"><span style=\"display:inline-block; width:32px; height:32px; background:#7b1fa2; color:#fff; border-radius:50%; text-align:center; line-height:32px; font-weight:bold;\">5<\/span><\/td>\n<td style=\"vertical-align:top; padding:8px 0;\"><strong>\u98df\u5f8c10\u5206\u306e\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0<\/strong><br \/>\u98df\u5f8c\u3059\u3050\u306e\u8efd\u3044\u904b\u52d5\u306f\u3001\u98df\u5f8c\u8840\u7cd6\u306e\u30d4\u30fc\u30af\u3092\u660e\u78ba\u306b\u6291\u3048\u307e\u3059\u3002\u6fc0\u3057\u3044\u904b\u52d5\u306f\u4e0d\u8981\u3002\u300c\u98df\u5f8c\u306f\u5ea7\u3089\u306a\u3044\u300d\u3092\u7fd2\u6163\u306b\u3002<\/td>\n<\/tr>\n<\/table>\n<\/div>\n<h2 style=\"background:#00796b; color:#ffffff; padding:14px 20px; border-radius:8px; margin:36px 0 20px 0;\">\u307e\u3068\u3081\u2500\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306f\u300c\u500b\u5225\u5316\u306e\u6642\u4ee3\u300d\u3078<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306f\u3053\u306e10\u5e74\u3067\u5927\u304d\u304f\u5909\u308f\u308a\u307e\u3057\u305f\u3002\u5358\u306b\u8840\u7cd6\u5024\u3092\u4e0b\u3052\u308b\u6642\u4ee3\u304b\u3089\u3001<strong>\u5fc3\u81d3\u30fb\u814e\u81d3\u3092\u5b88\u308a\u3001\u5065\u5eb7\u5bff\u547d\u3092\u5ef6\u3070\u3059\u6642\u4ee3<\/strong>\u3078\u3002\u305d\u3057\u3066\u3001<strong>\u4e00\u4eba\u3072\u3068\u308a\u306e\u75c5\u614b\u306b\u5408\u308f\u305b\u3066\u85ac\u3092\u9078\u3076\u500b\u5225\u5316\u533b\u7642\u306e\u6642\u4ee3<\/strong>\u3078\u3068\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u300c\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3051\u308c\u3069\u3001\u4f55\u304b\u3089\u59cb\u3081\u305f\u3089\u3044\u3044\u304b\u308f\u304b\u3089\u306a\u3044\u300d\u300c\u85ac\u3092\u98f2\u3093\u3067\u3044\u308b\u3051\u308c\u3069\u3053\u308c\u3067\u3044\u3044\u306e\u304b\u4e0d\u5b89\u300d\u300c\u89aa\u304c\u7cd6\u5c3f\u75c5\u306a\u306e\u3067\u3001\u81ea\u5206\u3082\u65e9\u3081\u306b\u5bfe\u7b56\u3057\u305f\u3044\u300d\u2500\u2500\u305d\u3093\u306a\u65b9\u306f\u3001\u305c\u3072\u5f53\u9662\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u9662\u9577\u4e94\u85e4\u304c\u3001\u3042\u306a\u305f\u306e\u75c5\u614b\u30fb\u751f\u6d3b\u80cc\u666f\u306b\u5408\u308f\u305b\u305f<strong>\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u306e\u6cbb\u7642\u30d7\u30e9\u30f3<\/strong>\u3092\u3054\u63d0\u6848\u3057\u307e\u3059\u3002<\/p>\n<p style=\"font-size:0.9em; color:#555;\">\u53c2\u7167\uff1a<br \/>\n\u30fb\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u300e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u30ac\u30a4\u30c92024-2025\u300f\u6587\u5149\u5802, 2024.<br \/>\n\u30fb\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u300c2\u578b\u7cd6\u5c3f\u75c5\u306e\u85ac\u7269\u7642\u6cd5\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u300d\uff08\u7b2c2\u7248\uff09\u7cd6\u5c3f\u75c5 2023;66(10):715-733.<br \/>\n\u30fbOhkubo Y, Kishikawa H, Araki E, et al. &#8216;Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.&#8217; Diabetes Res Clin Pract. 1995;28(2):103-17.<br \/>\n\u30fbShichiri M, Kishikawa H, Ohkubo Y, Wake N. &#8216;Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients.&#8217; Diabetes Care. 2000;23 Suppl 2:B21-9.<br \/>\n\u30fbUK Prospective Diabetes Study (UKPDS) Group. &#8216;Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34).&#8217; Lancet. 1998;352(9131):854-65.<br \/>\n\u30fbZinman B, Wanner C, Lachin JM, et al; EMPA-REG OUTCOME Investigators. &#8216;Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes.&#8217; N Engl J Med. 2015;373(22):2117-2128.<br \/>\n\u30fbWanner C, Inzucchi SE, Lachin JM, et al; EMPA-REG OUTCOME Investigators. &#8216;Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.&#8217; N Engl J Med. 2016;375(4):323-334.<br \/>\n\u30fbMarso SP, Daniels GH, Brown-Frandsen K, et al; LEADER Steering Committee; LEADER Trial Investigators. &#8216;Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.&#8217; N Engl J Med. 2016;375(4):311-22.<br \/>\n\u30fbBeck RW, Riddlesworth TD, Ruedy K, et al; DIAMOND Study Group. &#8216;Continuous Glucose Monitoring Versus Usual Care in Patients With Type 2 Diabetes Receiving Multiple Daily Insulin Injections: A Randomized Trial.&#8217; Ann Intern Med. 2017;167(6):365-374.<br \/>\n\u30fbMartens T, Beck RW, Bailey R, et al; MOBILE Study Group. &#8216;Effect of Continuous Glucose Monitoring on Glycemic Control in Patients With Type 2 Diabetes Treated With Basal Insulin: A Randomized Clinical Trial.&#8217; JAMA. 2021;325(22):2262-2272.<br \/>\n\u30fbBattelino T, Danne T, Bergenstal RM, et al. &#8216;Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.&#8217; Diabetes Care. 2019;42(8):1593-1603.<br \/>\n\u30fbNewman JC, Milman S, Hashmi SK, et al. &#8216;Strategies and Challenges in Clinical Trials Targeting Human Aging.&#8217; J Gerontol A Biol Sci Med Sci. 2016;71(11):1424-1434.<br \/>\n\u30fbNadon NL, Strong R, Miller RA, et al. &#8216;Design of aging intervention studies: the NIA interventions testing program.&#8217; Age (Dordr). 2008;30(4):187-199.<br \/>\n\u30fbHarrison DE, Strong R, Sharp ZD, et al. &#8216;Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.&#8217; Nature. 2009;460(7253):392-395.<br \/>\n\u30fbHarrison DE, Strong R, Allison DB, et al. &#8216;Acarbose, 17-\u03b1-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.&#8217; Aging Cell. 2014;13(2):273-282.<br \/>\n\u30fbStrong R, Miller RA, Astle CM, et al. &#8216;Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.&#8217; Aging Cell. 2008;7(5):641-650.<br \/>\n\u30fbMartin-Montalvo A, Mercken EM, Mitchell SJ, et al. &#8216;Metformin improves healthspan and lifespan in mice.&#8217; Nat Commun. 2013;4:2192.<br \/>\n\u30fbBaur JA, Pearson KJ, Price NL, et al. &#8216;Resveratrol improves health and survival of mice on a high-calorie diet.&#8217; Nature. 2006;444(7117):337-342.<br \/>\n\u30fbBannister CA, Holden SE, Jenkins-Jones S, et al. &#8216;Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.&#8217; Diabetes Obes Metab. 2014;16(11):1165-1173.<br \/>\n\u30fb\u4e94\u85e4\u826f\u5c06\u300e\u8840\u6db2\u3068\u4f53\u306e\u300c\u3042\u3076\u3089\u300d\u3092\u843d\u3068\u3059\u30b9\u30fc\u30d7\u300f\u30a2\u30b9\u30b3\u30e0, 2024.<br \/>\n\u30fbThe Emerging Risk Factors Collaboration, Sarwar N, Gao P, et al. &#8216;Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies.&#8217; Lancet. 2010;375(9733):2215-22.<br \/>\n\u30fbCheong AJY, Teo YN, Teo YH, et al. &#8216;SGLT inhibitors on weight and body mass: A meta-analysis of 116 randomized-controlled trials.&#8217; Obesity (Silver Spring). 2022;30(1):117-128.<br \/>\n\u30fb\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u300c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306e\u9069\u6b63\u4f7f\u7528\u306b\u95a2\u3059\u308bRecommendation\u300d\uff082020\u5e743\u670818\u65e5\u6539\u8a02\uff09.<br \/>\n\u30fbKaku K. &#8216;Pathophysiology of Type 2 Diabetes and Its Treatment Policy.&#8217; 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