{"id":6351,"date":"2025-04-18T13:52:43","date_gmt":"2025-04-18T04:52:43","guid":{"rendered":"https:\/\/www.takeuchi-iin.jp\/blog\/?p=6351"},"modified":"2026-05-22T21:02:14","modified_gmt":"2026-05-22T12:02:14","slug":"%e3%80%902025%e5%b9%b44%e6%9c%88%e7%89%88%e3%80%91ages%ef%bc%88%e7%b5%82%e6%9c%ab%e7%b3%96%e5%8c%96%e7%94%a8%e8%a3%bd%ef%bc%89%e3%81%a8%e3%81%af%ef%bc%9fnhk%e3%80%8e%e3%83%88%e3%83%aa%e3%82%bb","status":"publish","type":"post","link":"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%902025%e5%b9%b44%e6%9c%88%e7%89%88%e3%80%91ages%ef%bc%88%e7%b5%82%e6%9c%ab%e7%b3%96%e5%8c%96%e7%94%a8%e8%a3%bd%ef%bc%89%e3%81%a8%e3%81%af%ef%bc%9fnhk%e3%80%8e%e3%83%88%e3%83%aa%e3%82%bb\/","title":{"rendered":"\u30102025\u5e744\u6708\u7248\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7528\u88fd\uff09\u3068\u306f\uff1fNHK\u300e\u30c8\u30ea\u30bb\u30c4\u300f\u3067\u6ce8\u76ee\u3055\u308c\u305f\u201c\u7cd6\u5c3f\u75c5\u3068\u8001\u5316\u201d\u3092\u3064\u306a\u3050\u30ea\u30b9\u30af\u7269\u8cea\u3092\u5f37\u8abf\u89e3\u8aac"},"content":{"rendered":"\n<p>\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u306e<strong><a href=\"https:\/\/www.youtube.com\/@GOCCI510\" target=\"_blank\" rel=\"noopener\" title=\"\">\u4e94\u85e4\u826f\u5c06\uff08\u5185\u79d1\u533b\u3054\u3063\u3061\uff09<\/a><\/strong>\u3067\u3059\u30022025\u5e744\u670813\u65e5\uff08\u6728\uff09\u3001<strong><a href=\"https:\/\/www.nhk.jp\/p\/torisetsu-show\/ts\/J6MX7VP885\/\" target=\"_blank\" rel=\"noopener\" title=\"\">NHK\u300e\u3042\u3057\u305f\u304c\u5909\u308f\u308b \u30c8\u30ea\u30bb\u30c4\u30b7\u30e7\u30fc\u300f<\/a><\/strong>\u306b\u3066AGEs\u306e\u7279\u96c6\u304c\u653e\u9001\u3055\u308c\u305f\u5f71\u97ff\u3067\u3001\u5f53\u9662\u306b\u3082AGEs\u6e2c\u5b9a\u3092\u3054\u5e0c\u671b\u3055\u308c\u308b\u60a3\u8005\u69d8\u304c\u3061\u3089\u307b\u3089\u6765\u9662\u3055\u308c\u3066\u304a\u308a\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u9802\u304f\u3068NHK\u306e\u300c\u7cd6\u5316\u300d\u306e\u56de\u306e\u8a73\u7d30\u306b\u8fbf\u308a\u7740\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.nhk.jp\/p\/torisetsu-show\/ts\/J6MX7VP885\/episode\/te\/LWMGM7L5R2\/\"><img decoding=\"async\" width=\"985\" height=\"772\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/9f4b5ea81e86f443ab93f04b9f98fb47.jpg\" alt=\"\u4ee5\u4e0b\u306e\u753b\u50cf\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u9802\u304f\u3068NHK\u306e\u300c\u7cd6\u5316\u300d\u306e\u56de\u306e\u8a73\u7d30\u306b\u8fbf\u308a\u7740\u3051\u307e\u3059\u3002\" class=\"wp-image-6352\" srcset=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/9f4b5ea81e86f443ab93f04b9f98fb47.jpg 985w, https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/9f4b5ea81e86f443ab93f04b9f98fb47-300x235.jpg 300w, https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/9f4b5ea81e86f443ab93f04b9f98fb47-768x602.jpg 768w, https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/9f4b5ea81e86f443ab93f04b9f98fb47-850x666.jpg 850w, https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/9f4b5ea81e86f443ab93f04b9f98fb47-480x376.jpg 480w\" sizes=\"(max-width: 985px) 100vw, 985px\" \/><\/a><\/figure>\n\n\n\n<p>\u5f53\u9662\u306f\u30b3\u30ed\u30ca\u798d\u524d\u304b\u3089AGEs\u6e2c\u5b9a\u5668\u300cAGE Reader\u300d\u3092\u5c0e\u5165\u3057\u3066\u304a\u308a\u3001\u76ae\u819a\u304b\u3089\u975e\u4fb5\u8972\u7684\u306bAGEs\uff08\u6700\u7d42\u7cd6\u5316\u7523\u7269\uff09\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u79c1\u3001<strong><a href=\"https:\/\/www.youtube.com\/@GOCCI510\" target=\"_blank\" rel=\"noopener\" title=\"\">\u4e94\u85e4\u826f\u5c06\uff08\u5185\u79d1\u533b\u3054\u3063\u3061\uff09<\/a><\/strong>\u304cAGEs\u306b\u3064\u3044\u3066\u3001\u6700\u65b0\u306e\u7814\u7a76\u3084\u81e8\u5e8a\u5fdc\u7528\u3082\u8e0f\u307e\u3048\u306a\u304c\u3089\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3066\u307e\u3044\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">NHK\u3067\u8a71\u984c\uff01\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8ee2\u5012\u3092\u3064\u306a\u3050AGEs\u3068\u306f\uff1f<\/h2>\n\n\n\n<p>NHK\u300e\u30c8\u30ea\u30bb\u30c4\u300f\u3067\u7279\u96c6\u3055\u308c\u3001\u5927\u304d\u306a\u53cd\u97ff\u3092\u547c\u3093\u3060\u300cAGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u300d\u3002\u7cd6\u5c3f\u75c5\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u8a8d\u77e5\u75c7\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u75c5\u3060\u3051\u3067\u306a\u304f\u3001\u9ad8\u9f62\u8005\u306e\u30d5\u30ec\u30a4\u30eb\uff08\u865a\u5f31\uff09\u3084\u8ee2\u5012\u30ea\u30b9\u30af\u3068\u3082\u6df1\u304f\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>&#8220;AGEs (Advanced Glycation End-products)&#8221; were recently featured on NHK&#8217;s &#8220;Torisetsu&#8221; program and have attracted attention for their roles in diabetes, cardiovascular disease, dementia, and even frailty and fall risk in elderly individuals.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">AGEs\u3068\u306f\uff1f\uff08What are AGEs?\uff09<\/h2>\n\n\n\n<p>AGEs\u306f\u3001\u7cd6\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u8102\u8cea\u304c\u7e4b\u304c\u3063\u3066\u3067\u304d\u308b\u300c\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u300d\u306e\u6700\u7d42\u7523\u7269\u3067\u3059\u3002\u3053\u308c\u304c\u4f53\u5185\u306b\u84c4\u7a4d\u3059\u308b\u3068\u3001\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u60aa\u5316\u3055\u305b\u3001\u75c5\u6c17\u306e\u767a\u75c7\u3084\u8001\u5316\u3092\u52a9\u9577\u3059\u308b\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>AGEs are harmful compounds formed through glycation, where sugars bind to proteins or lipids. Accumulation of AGEs in tissues leads to cellular damage and contributes to aging and chronic diseases.<\/p>\n\n\n\n<p>\u3010\u5b9f\u969b\u306e\u7814\u7a76\u3011<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Meerwaldt R et al. &#8220;Simple non-invasive assessment of advanced glycation endproduct accumulation.&#8221; <em>Diabetologia<\/em>. 2004;47(7):1324-1330. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15243705\/\" target=\"_blank\" rel=\"noopener\" title=\"\">doi:[10.1007\/s00125-004-1451-2]<\/a><\/li>\n\n\n\n<li>Meerwaldt R et al. &#8220;Skin autofluorescence is a strong predictor of cardiac mortality in diabetes.&#8221; <em>Diabetes Care<\/em>. 2007;30(1):107-112. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17192342\/\" target=\"_blank\" rel=\"noopener\" title=\"\">doi:[10.2337\/dc06-1391]<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">AGE Reader \u306b\u3088\u308b\u975e\u4fb5\u8972\u7684\u6e2c\u5b9a<\/h2>\n\n\n\n<p>\u5f53\u9662\u3067\u306f\u3001\u76ae\u819a\u306eAGEs\u306e\u84c4\u7a4d\u3092\u3001\u975e\u4fb5\u6483\u7684\u306a\u65b9\u6cd5\u3067\u6e2c\u5b9a\u3067\u304d\u308b\u300cAGE Reader\u300d\u3092\u5c0e\u5165\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>The AGE Reader enables non-invasive, real-time measurement of skin AGEs through autofluorescence technology.<\/p>\n\n\n\n<p>\u3010\u8a3a\u65ad\u7cbe\u5ea6\u306e\u88dc\u8aac\u3011<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AGE Reader\u306e\u6e2c\u5b9a\u5024\u306f\u3001\u76ae\u819a\u751f\u691c\u3067\u76f4\u63a5\u8abf\u3079\u305fAGEs\u3068\u9ad8\u3044\u76f8\u95a2\u6027\u3092\u793a\u3057\uff08r = 0.87\uff09\u3002<\/li>\n\n\n\n<li>\u518d\u73fe\u6027\u3082\u9ad8\u304f\uff0c\u65e5\u5185\uff0f\u65e5\u9593CV&lt;5%\u3068\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u8ee2\u5012\u30ea\u30b9\u30af\u3068AGEs\u306e\u95a2\u4fc2<\/h2>\n\n\n\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001AGEs\u306e\u5024\u304c\u9ad8\u3044\u9ad8\u9f62\u8005\u306f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8ee2\u5012\u7d4c\u9a13\u304c\u591a\u3044<\/li>\n\n\n\n<li>\u30d0\u30e9\u30f3\u30b9\u80fd\u529b\u3084\u7b4b\u8089\u91cf\u306b\u554f\u984c\u304c\u3042\u308b<\/li>\n\n\n\n<li>\u30d5\u30ec\u30a4\u30eb\u3001\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u3001\u9aa8\u5bc6\u5ea6\u306e\u4f4e\u4e0b\u3084\u9aa8\u7c97\u9b06\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u308b<\/li>\n<\/ul>\n\n\n\n<p>Studies report that high AGE levels in the elderly are associated with increased fall risk, lower muscle mass, and greater frailty.<\/p>\n\n\n\n<p>\u3010\u53c2\u7167\u7db2\u9801\u3011<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u300c<a href=\"https:\/\/preview.mailerlite.com\/b2x9h5n3k7\">AGEs\u3068\u9ad8\u9f62\u8005\u306e\u8ee2\u5012\u30ea\u30b9\u30af\u306e\u95a2\u4fc2<\/a>\u300d<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u7cd6\u5c3f\u75c5\u3068AGEs\uff1a\u9759\u304b\u306b\u9032\u884c\u3059\u308b\u30ea\u30b9\u30af<\/h2>\n\n\n\n<p>\u9ad8\u3044HbA1c\u3084\u9ad8\u8840\u7cd6\u72b6\u614b\u304c\u7d9a\u304f\u3053\u3068\u3067\u3001AGEs\u306e\u84c4\u7a4d\u304c\u52a0\u901f\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u300c\u7cd6\u5316\u8a18\u61b6\uff08glycemic memory\uff09\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u904e\u53bb\u306e\u9ad8\u8840\u7cd6\u304c\u3001\u4eca\u306e\u8102\u8cea\u306e\u50cd\u304d\u3084\u8840\u7ba1\u3084\u795e\u7d4c\u6a5f\u80fd\u306b\u3082\u9577\u671f\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Persistent hyperglycemia leads to AGE accumulation and contributes to chronic complications in diabetes, even after glycemic control is improved.<\/p>\n\n\n\n<p>\u3010\u5b9f\u969b\u306e\u7814\u7a76\u3011<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rigo M et al. &#8220;Skin autofluorescence, a marker of glucose memory in type 2 diabetes.&#8221; <em>Metabol Open<\/em>. 2020;7:100038. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32812941\/\" target=\"_blank\" rel=\"noopener\" title=\"\">doi:[10.1016\/j.metop.2020.100038]<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u3053\u306e\u8a18\u4e8b\u3068\u540c\u6642\u306b\u8aad\u3093\u3067\u307b\u3057\u3044\u904e\u53bb\u8a18\u4e8b<\/h2>\n\n\n\n<p>\u3088\u308a\u8a73\u3057\u3044AGEs\u306e\u57fa\u790e\u89e3\u8aac\u306f\u3001\u3053\u3061\u3089\u3082\u305c\u3072\u3054\u4e00\u8aad\u304f\u3060\u3055\u3044\uff1a<\/p>\n\n\n\n<p><strong>\u2192 <a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/\" target=\"_blank\" rel=\"noopener\" title=\"\">AGEs\uff1c\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\uff1e\u8001\u5316\u7269\u8cea\u306e\u84c4\u7a4d\u3092\u30c1\u30a7\u30c3\u30af\uff01<\/a><\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u7d42\u308f\u308a\u306b<\/h2>\n\n\n\n<p>AGEs\u306f\u300c\u898b\u3048\u306a\u3044\u8001\u5316\u300d\u3092\u53ef\u8996\u5316\u3059\u308b\u30de\u30fc\u30ab\u30fc\u3067\u3059\u3002\u7cd6\u5c3f\u75c5\u3001\u52a0\u9f62\u3001\u30d5\u30ec\u30a4\u30eb\u3001\u8ee2\u5012\u3084\u5bdd\u305f\u304d\u308a\u306e\u4e88\u9632\u3092\u8003\u3048\u308b\u4e0a\u3067\u3082\u3001AGE Reader\u306b\u3088\u308b\u6e2c\u5b9a\u306f\u6709\u7528\u3067\u3059\u3002<\/p>\n\n\n\n<p>Monitoring AGEs offers a new perspective in preventing chronic diseases and preserving functional independence, especially in aging populations.<\/p>\n\n\n\n<p><strong>AGEs\u691c\u67fb\u3001\u3044\u3064\u3067\u3082\u5f53\u9662\u3067\u3054\u76f8\u8ac7\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p>\u5f53\u9662\u3067\u3001<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%90d-gs%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%80%91%e3%80%90d-gs%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%af%e3%83%aa%e3%83%bc%e3%83%a0%e3%80%91%e8%b2%a9%e5%a3%b2\/\" target=\"_blank\" rel=\"noopener\" title=\"\"><strong>\u3010d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3011\u3010d-Gs\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\u3011\u8ca9\u58f2<\/strong><\/a>\u958b\u59cb\u3044\u305f\u3057\u307e\u3057\u305f\u3002<strong><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%90d-gs%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%80%91%e3%80%90d-gs%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%af%e3%83%aa%e3%83%bc%e3%83%a0%e3%80%91%e8%b2%a9%e5%a3%b2\/\" target=\"_blank\" rel=\"noopener\" title=\"\">\u3010\u3053\u3061\u3089\u3011<\/a><\/strong>\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%90d-gs%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%80%91%e3%80%90d-gs%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%af%e3%83%aa%e3%83%bc%e3%83%a0%e3%80%91%e8%b2%a9%e5%a3%b2\/\" target=\"_blank\" rel=\" noreferrer noopener\"><img decoding=\"async\" width=\"634\" height=\"941\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/image-2.jpg\" alt=\"\" class=\"wp-image-6411\" srcset=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/04\/image-2.jpg 634w, 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