{"id":2137,"date":"2025-11-08T20:45:00","date_gmt":"2025-11-08T11:45:00","guid":{"rendered":"https:\/\/www.takeuchi-iin.jp\/blog\/?p=2137"},"modified":"2026-05-02T01:47:58","modified_gmt":"2026-05-01T16:47:58","slug":"ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83","status":"publish","type":"post","link":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/","title":{"rendered":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185"},"content":{"rendered":"

\u7686\u3055\u307e\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u306e\u4e94\u85e4\u826f\u5c06\u3067\u3059\u3002<\/p>\n

\u79c1\u305f\u3061\u306e\u4f53\u306f\u6bce\u65e5\u5c11\u3057\u305a\u3064\u300c\u7126\u3052\u3066\u300d\u3044\u308b\u3053\u3068\u3092\u3054\u5b58\u3058\u3067\u3059\u304b\uff1f\u3053\u306e\u300c\u4f53\u306e\u7126\u3052\u3064\u304d\u300d\u306e\u6b63\u4f53\u304c\u3001\u8fd1\u5e74\u533b\u5b66\u754c\u3067\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u308bAGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff1aAdvanced Glycation End-products\uff09<\/strong>\u3067\u3059\u3002AGEs\u306f\u5358\u306a\u308b\u8001\u5316\u306e\u6307\u6a19\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u3001\u52d5\u8108\u786c\u5316\u3001\u8a8d\u77e5\u75c7\u3001\u9aa8\u7c97\u9b06\u75c7\u3001\u3046\u3064\u75c5\u3001\u3055\u3089\u306b\u306f\u30d5\u30ec\u30a4\u30eb\uff08\u865a\u5f31\uff09\u3084\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\uff08\u7b4b\u8089\u6e1b\u5c11\u75c7\uff09\u306b\u307e\u3067\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u3001\u4e16\u754c\u5404\u56fd\u306e\u5927\u898f\u6a21\u7814\u7a76\u3067\u6b21\u3005\u3068\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5f53\u9662\u3067\u306f\u3001\u8155\u3092\u6e2c\u5b9a\u5668\u306b\u4e57\u305b\u308b\u3060\u3051\u306e\u7c21\u5358\u306a\u691c\u67fb\uff08\u7d0412\u79d2\uff09\u3067\u3001\u4f53\u5185\u306eAGEs\u84c4\u7a4d\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u6700\u65b0\u306e\u533b\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u4ea4\u3048\u306a\u304c\u3089\u3001AGEs\u304c\u5168\u8eab\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3068\u3001\u305d\u306e\u5bfe\u7b56\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n

\"AGEs\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\"<\/p>\n

\n

1. AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u306f\uff1f\u2015 \u7cd6\u5316\u53cd\u5fdc\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n

\"AGEs\u8aac\u660e\"<\/p>\n

\"AGEs\u8aac\u660e2\"<\/p>\n

AGEs\u3068\u306f\u3001\u4f53\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u8102\u8cea<\/strong>\u304c\u7cd6\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u3084\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u306a\u3069\uff09<\/strong>\u3068\u975e\u9175\u7d20\u7684\u306b\u7d50\u5408\u3057\u3066\u751f\u3058\u308b\u7269\u8cea\u306e\u7dcf\u79f0\u3067\u3059\u3002\u3053\u306e\u53cd\u5fdc\u306f\u300c\u30e1\u30a4\u30e9\u30fc\u30c9\u53cd\u5fdc\uff08\u7cd6\u5316\u53cd\u5fdc\uff09\u300d<\/strong>\u3068\u547c\u3070\u308c\u3001\u98df\u54c1\u3092\u52a0\u71b1\u3057\u305f\u969b\u306b\u3053\u3093\u304c\u308a\u3068\u3057\u305f\u713c\u304d\u8272\u304c\u3064\u304f\u73fe\u8c61\u3068\u540c\u3058\u5316\u5b66\u53cd\u5fdc\u304c\u3001\u4f53\u6e2937\u2103\u306e\u4f53\u5185\u3067\u3082\u3086\u3063\u304f\u308a\u3068\u9032\u884c\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n

AGEs\u751f\u6210\u306e3\u6bb5\u968e\u30e1\u30ab\u30cb\u30ba\u30e0<\/p>\n

1<\/span>\u521d\u671f\u53cd\u5fdc\uff08\u53ef\u9006\u7684\uff09<\/strong>\uff1a\u30b0\u30eb\u30b3\u30fc\u30b9\u306a\u3069\u306e\u9084\u5143\u7cd6\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a2\u30df\u30ce\u57fa\uff08\u30ea\u30b8\u30f3\u6b8b\u57fa\u3084\u30a2\u30eb\u30ae\u30cb\u30f3\u6b8b\u57fa\uff09\u3068\u7d50\u5408\u3057\u3001\u30b7\u30c3\u30d5\u5869\u57fa<\/strong>\u3092\u5f62\u6210<\/p>\n

2<\/span>\u4e2d\u671f\u53cd\u5fdc<\/strong>\uff1a\u30b7\u30c3\u30d5\u5869\u57fa\u304c\u30a2\u30de\u30c9\u30ea\u8ee2\u4f4d<\/strong>\u3092\u8d77\u3053\u3057\u3001\u300c\u30a2\u30de\u30c9\u30ea\u5316\u5408\u7269\u300d\uff08\u524d\u671f\u7cd6\u5316\u7523\u7269\uff09\u3092\u751f\u6210 \u203bHbA1c\u306f\u3053\u306e\u6bb5\u968e\u306e\u4ee3\u8868\u7684\u6307\u6a19<\/p>\n

3<\/span>\u5f8c\u671f\u53cd\u5fdc\uff08\u4e0d\u53ef\u9006\u7684\uff09<\/strong>\uff1a\u9178\u5316\u30fb\u8131\u6c34\u30fb\u7e2e\u5408\u53cd\u5fdc\u3092\u7d4c\u3066\u3001AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09<\/strong>\u304c\u6700\u7d42\u7684\u306b\u5f62\u6210\u3055\u308c\u308b<\/p>\n<\/div>\n

\u91cd\u8981\u306a\u306e\u306f\u3001AGEs\u306f\u4e00\u5ea6\u751f\u6210\u3055\u308c\u308b\u3068\u5206\u89e3\u30fb\u6392\u51fa\u304c\u6975\u3081\u3066\u56f0\u96e3<\/strong>\u3067\u3042\u308b\u3053\u3068\u3067\u3059\u3002\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u534a\u6e1b\u671f\u306e\u9577\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u84c4\u7a4d\u3059\u308b\u3068\u3001\u751f\u6daf\u306b\u308f\u305f\u3063\u3066\u7d44\u7e54\u306b\u7559\u307e\u308a\u7d9a\u3051\u307e\u3059\u3002\u751f\u4f53\u5185\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u4e3b\u306aAGEs\u69cb\u9020\u4f53\u306b\u306f\u4ee5\u4e0b\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\n

\u4ee3\u8868\u7684\u306aAGEs\u69cb\u9020\u4f53<\/p>\n

Nε-\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u30ea\u30b8\u30f3\uff08CML\uff09<\/strong>\uff1a\u975e\u86cd\u5149\u6027\u30fb\u975e\u67b6\u6a4b\u6027\u3002\u8840\u4e2d\u3067\u6700\u3082\u591a\u304f\u691c\u51fa\u3055\u308c\u308bAGEs\u3067\u3001RAGE\uff08\u53d7\u5bb9\u4f53\uff09\u306e\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u60f9\u8d77<\/p>\n

\u30da\u30f3\u30c8\u30b7\u30b8\u30f3<\/strong>\uff1a\u86cd\u5149\u6027\u30fb\u67b6\u6a4b\u6027\u3002\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08SAF\uff09\u6e2c\u5b9a\u306e\u4e3b\u8981\u30bf\u30fc\u30b2\u30c3\u30c8\u3002\u30b3\u30e9\u30fc\u30b2\u30f3\u67b6\u6a4b\u306b\u3088\u308b\u7d44\u7e54\u786c\u5316\u306b\u95a2\u4e0e<\/p>\n

\u30e1\u30c1\u30eb\u30b0\u30ea\u30aa\u30ad\u30b5\u30fc\u30eb\u30ea\u30b8\u30f3\u30c0\u30a4\u30de\u30fc\uff08MOLD\uff09<\/strong>\uff1a\u975e\u86cd\u5149\u6027\u30fb\u67b6\u6a4b\u6027\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u306e\u75c5\u7684\u67b6\u6a4b\u3092\u5f62\u6210<\/p>\n

\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u7531\u6765AGEs\uff08Glycer-AGEs\uff09<\/strong>\uff1a\u6bd2\u6027\u304c\u7279\u306b\u5f37\u304f\u3001\u809d\u81d3\u75be\u60a3\uff08NASH\uff09\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u306e\u95a2\u9023\u304c\u5831\u544a<\/p>\n<\/div>\n

\"AGEs\u306e\u4f53\u3078\u306e\u5f71\u97ff\"<\/p>\n

AGEs\u306e2\u3064\u306e\u4f9b\u7d66\u7d4c\u8def<\/h3>\n

\u4f53\u5185\u306bAGEs\u304c\u84c4\u7a4d\u3059\u308b\u7d4c\u8def\u306f\u5927\u304d\u304f2\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n

\n

AGEs\u84c4\u7a4d\u306e2\u5927\u7d4c\u8def<\/p>\n

1. \u5185\u56e0\u6027AGEs\uff08\u5168\u4f53\u306e\u7d042\/3\uff09<\/strong>\uff1a\u9ad8\u8840\u7cd6\u72b6\u614b\u304c\u6301\u7d9a\u3059\u308b\u3068\u3001\u8840\u4e2d\u306e\u904e\u5270\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u4f53\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3066AGEs\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306f\u3053\u306e\u7d4c\u8def\u304c\u8457\u3057\u304f\u4ea2\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

2. \u5916\u56e0\u6027AGEs\uff08\u5168\u4f53\u306e\u7d041\/3\uff09<\/strong>\uff1a\u98df\u54c1\u3092\u9ad8\u6e29\u3067\u52a0\u71b1\u8abf\u7406\uff08\u63da\u3052\u308b\u30fb\u713c\u304f\u30fb\u7092\u3081\u308b\uff09\u3057\u305f\u969b\u306b\u751f\u6210\u3055\u308c\u308bAGEs\u3092\u98df\u4e8b\u304b\u3089\u6442\u53d6\u3059\u308b\u7d4c\u8def\u3067\u3059\u3002\u6442\u53d6\u3057\u305f\u5916\u56e0\u6027AGEs\u306e\u7d047\u5272\u304c\u4f53\u5185\u306b\u6b8b\u7559\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u55ab\u7159\u3082AGEs\u306e\u91cd\u8981\u306a\u5916\u56e0\u6027\u4f9b\u7d66\u6e90\u3067\u3042\u308a\u3001\u30bf\u30d0\u30b3\u306e\u8449\u3092\u4e7e\u71e5\u3055\u305b\u308b\u904e\u7a0b\u3067\u751f\u3058\u305fAGEs\u304c\u80ba\u304b\u3089\u5438\u53ce\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n

\"\u30db\u30c3\u30c8\u30b1\u30fc\u30ad\u306e\u7cd6\u5316\u4f8b\"<\/p>\n

\u5206\u304b\u308a\u3084\u3059\u3044\u4f8b\u3068\u3057\u3066\u3001\u30db\u30c3\u30c8\u30b1\u30fc\u30ad\u304c\u3042\u308a\u307e\u3059\u3002\u5c0f\u9ea6\u7c89\uff08\u7cd6\u8cea\uff09\u3092\u7df4\u3063\u3066\u3001\u725b\u4e73\u3084\u5375\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u52a0\u3048\u3066\u713c\u3044\u305f\u3068\u304d\u306e\u3001\u304d\u3064\u306d\u8272\u306e\u7126\u3052\u76ee\u3053\u305d\u304cAGEs\u3067\u3059\u3002\u30b9\u30c6\u30fc\u30ad\u3084\u30c8\u30fc\u30b9\u30c8\u306e\u8910\u8272\u306e\u7126\u3052\u76ee\u306b\u3082AGEs\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u79c1\u305f\u3061\u306f\u65e5\u5e38\u7684\u306bAGEs\u3092\u4f53\u5185\u306b\u53d6\u308a\u5165\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

\n

2. AGEs\u306f\u306a\u305c\u5371\u967a\u304b\uff1f\u2015 RAGE\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u5168\u8eab\u3078\u306e\u5f71\u97ff<\/h2>\n

\"AGEs\u84c4\u7a4d\u306e\u4ed5\u7d44\u307f\"<\/p>\n

AGEs\u304c\u4f53\u306b\u5bb3\u3092\u53ca\u307c\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u5927\u304d\u304f2\u3064\u306e\u7d4c\u8def<\/strong>\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u7d4c\u8def1\uff1a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u67b6\u6a4b\u5f62\u6210\uff08\u69cb\u9020\u7684\u969c\u5bb3\uff09<\/h3>\n

AGEs\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306a\u3069\u306e\u9577\u5bff\u547d\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u75c5\u7684\u306a\u67b6\u6a4b\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30af\uff09<\/strong>\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u7d44\u7e54\u304c\u786c\u304f\u8106\u304f\u306a\u308a\u3001\u8840\u7ba1\u58c1\u306e\u5f3e\u529b\u4f4e\u4e0b\uff08\u52d5\u8108\u786c\u5316\uff09\u3001\u76ae\u819a\u306e\u3057\u308f\u30fb\u305f\u308b\u307f\u3001\u9aa8\u5f37\u5ea6\u306e\u4f4e\u4e0b\uff08\u9aa8\u7c97\u9b06\u75c7\uff09\u3001\u95a2\u7bc0\u306e\u3053\u308f\u3070\u308a\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n

\u7d4c\u8def2\uff1aRAGE\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u708e\u75c7\u30fb\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff08\u6a5f\u80fd\u7684\u969c\u5bb3\uff09<\/h3>\n

AGEs\u306f\u7d30\u80de\u8868\u9762\u306eRAGE\uff08Receptor for AGEs\uff1aAGEs\u53d7\u5bb9\u4f53\uff09<\/strong>\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001NF-κB\u7d4c\u8def<\/strong>\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TNF-α\u3001IL-6\u306a\u3069\uff09\u306e\u7523\u751f\u4ea2\u9032\u3001\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306e\u5927\u91cf\u751f\u6210\u3001\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002\u6162\u6027\u7684\u306aAGE-RAGE\u523a\u6fc0\u306f\u3001\u5168\u8eab\u306e\u81d3\u5668\u306b\u6301\u7d9a\u7684\u306a\u708e\u75c7\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u3082\u305f\u3089\u3057\u3001\u591a\u81d3\u5668\u306b\u308f\u305f\u308b\u75be\u60a3\u306e\u767a\u75c7\u30fb\u9032\u5c55\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n

\n

AGE-RAGE\u7cfb\u304c\u5f15\u304d\u8d77\u3053\u3059\u4e3b\u306a\u751f\u4f53\u53cd\u5fdc<\/p>\n

NF-κB\u6d3b\u6027\u5316 \u2192 \u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u4ea2\u9032<\/p>\n

NADPH \u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u6d3b\u6027\u5316 \u2192 \u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u7523\u751f\u5897\u52a0<\/p>\n

NO\uff08\u4e00\u9178\u5316\u7a92\u7d20\uff09\u7523\u751f\u4f4e\u4e0b \u2192 \u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3<\/p>\n

VEGF\u767a\u73fe\u4ea2\u9032 \u2192 \u8840\u7ba1\u900f\u904e\u6027\u4ea2\u9032\u30fb\u75c5\u7684\u8840\u7ba1\u65b0\u751f<\/p>\n

\u63a5\u7740\u5206\u5b50\uff08VCAM-1\u3001ICAM-1\uff09\u767a\u73fe\u4e0a\u6607 \u2192 \u52d5\u8108\u786c\u5316\u4fc3\u9032<\/p>\n<\/div>\n

\n

3. AGEs\u3068\u5168\u8eab\u75be\u60a3 \u2015 \u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9<\/h2>\n

\"AGEs\u3068\u95a2\u9023\u75be\u60a3\"<\/p>\n

AGEs\u306e\u84c4\u7a4d\u306f\u3001\u5168\u8eab\u306e\u3042\u3089\u3086\u308b\u81d3\u5668\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002\u82b1\u738b\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u4f1a\u306e\u30c7\u30fc\u30bf\u306b\u3088\u308c\u3070\u3001\u30aa\u30e9\u30f3\u30c0\u3067\u5b9f\u65bd\u3055\u308c\u305f7\u4e07\u4eba\u4ee5\u4e0a\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u7814\u7a76<\/strong>\u3067\u306f\u3001AGEs\u84c4\u7a4d\u304c\u591a\u3044\u30b0\u30eb\u30fc\u30d7\u306f\u7cd6\u5c3f\u75c5\u3084\u5fc3\u81d3\u75c5\u306b3\u500d<\/strong>\u304b\u304b\u308a\u3084\u3059\u304f\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c5\u500d<\/strong>\u3001\u5bff\u547d\u304c\u660e\u3089\u304b\u306b\u77ed\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u3001\u6700\u65b0\u306e\u7814\u7a76\u77e5\u898b\u3092\u81d3\u5668\u5225\u306b\u307e\u3068\u3081\u307e\u3059\u3002<\/p>\n

3-1. \u5fc3\u8840\u7ba1\u75be\u60a3\u30fb\u8840\u7ba1\u8001\u5316<\/h3>\n
\n

\u91cd\u8981 \u30a8\u30d3\u30c7\u30f3\u30b9<\/p>\n

de Vos\u3089\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08Arterioscler Thromb Vasc Biol, 2014\uff09\u3067\u306f\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u60a3\u8005252\u540d\u30925\u5e74\u9593\u8ffd\u8de1\u3057\u3001\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08SAF\uff09\u3067\u6e2c\u5b9a\u3057\u305fAGEs\u84c4\u7a4d\u91cf\u304c\u3001\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u88dc\u6b63\u5f8c\u3082\u5168\u6b7b\u4ea1\u304a\u3088\u3073\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u72ec\u7acb\u3057\u305f\u4e88\u6e2c\u56e0\u5b50<\/strong>\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

AGEs\u306f\u8840\u7ba1\u58c1\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u67b6\u6a4b\u3092\u5f62\u6210\u3057\u3066\u8840\u7ba1\u3092\u786c\u5316\u3055\u305b\u3001\u52d5\u8108\u786c\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u540c\u6642\u306bRAGE\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u306b\u3088\u308a\u3001NO\uff08\u4e00\u9178\u5316\u7a92\u7d20\uff09\u7523\u751f\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u7ba1\u62e1\u5f35\u80fd\u304c\u640d\u306a\u308f\u308c\u307e\u3059\u3002\u3053\u306e\u8840\u7ba1\u6a5f\u80fd\u969c\u5bb3\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u5897\u5927\u3060\u3051\u3067\u306a\u304f\u3001\u52c3\u8d77\u4e0d\u5168\uff08ED\uff09<\/strong>\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002ED\u306f\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u306e\u521d\u671f\u75c7\u72b6\u3068\u3057\u3066\u73fe\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u75c7\u306b\u6570\u5e74\u5148\u884c\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

3-2. \u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7<\/h3>\n

\u7cd6\u5c3f\u75c5\u306f\u300c\u8eab\u4f53\u3092\u8001\u5316\u3055\u305b\u308b\u75c5\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u9ad8\u8840\u7cd6\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u9ad8\u8102\u8840\u75c7\u306a\u3069\u306e\u75c5\u7684\u72b6\u614b\u3067\u306fAGEs\u751f\u6210\u91cf\u304c\u8457\u3057\u304f\u5897\u52a0\u3057\u307e\u3059\u3002AGEs\u306e\u84c4\u7a4d\u306f\u7cd6\u5c3f\u75c5\u306e\u4e09\u5927\u5408\u4f75\u75c7<\/strong>\uff08\u7db2\u819c\u75c7\u30fb\u814e\u75c7\u30fb\u795e\u7d4c\u969c\u5bb3\uff09\u306e\u3059\u3079\u3066\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u5927\u8840\u7ba1\u969c\u5bb3\uff08\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\uff09\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3082\u9ad8\u3081\u307e\u3059\u3002<\/p>\n

\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aCKD\uff08\u6162\u6027\u814e\u81d3\u75c5\uff09\u3068AGEs<\/p>\n

\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u60a3\u8005\u3067\u306f\u3001\u814e\u81d3\u3067\u306eAGEs\u6392\u6cc4\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u4f53\u5185\u84c4\u7a4d\u304c\u52a0\u901f\u3057\u3001AGEs\u3068\u9aa8\u4ee3\u8b1d\u7570\u5e38\uff08\u814e\u6027\u9aa8\u7570\u6804\u990a\u75c7\uff09<\/strong>\u3001\u5c3f\u7d30\u7ba1\u969c\u5bb3<\/strong>\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u8840\u6db2\u900f\u6790\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u306e\u7d4c\u6642\u7684\u4e0a\u6607\u304c\u6b7b\u4ea1\u7387\u306e\u72ec\u7acb\u4e88\u6e2c\u56e0\u5b50<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Meerwaldt R, et al. Diabetologia, 2004\uff09\u3002<\/p>\n<\/div>\n

\n

\u95a2\u9023\u8a18\u4e8b\uff1a\u7cd6\u5c3f\u75c5\u6cbb\u7642\u3068\u6297\u7cd6\u5316<\/p>\n

\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\u3067\u306f\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u963b\u5bb3\u85ac\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u3044\u3063\u305f\u85ac\u5264\u304c\u3001\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3092\u8d85\u3048\u305f\u591a\u9762\u7684\u52b9\u679c\uff08\u5fc3\u8840\u7ba1\u4fdd\u8b77\u30fb\u814e\u4fdd\u8b77\u30fb\u6297AGE\u4f5c\u7528\uff09\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8a73\u3057\u304f\u306f \u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\uff5c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u30fbCGM\u500b\u5225\u5316\uff0b\u6297\u8001\u5316\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u307e\u305f\u3001\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\u306e\u9032\u884c\u306b\u306f\u5185\u81d3\u8102\u80aa\u7531\u6765\u306e\u6162\u6027\u708e\u75c7\u3068\u9ad8\u8840\u7cd6\u304cAGE\u84c4\u7a4d\u3092\u52a0\u901f\u3055\u305b\u308b\u60aa\u5faa\u74b0\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002\u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\uff5c2024\u5e74\u65b0\u57fa\u6e96\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3092\u5fb9\u5e95\u89e3\u8aac\u300d<\/strong><\/a>\u3082\u3042\u308f\u305b\u3066\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u7cd6\u5c3f\u75c5\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u65b9\u306f\u3001\u767a\u75c7\u524d\u304b\u3089AGE\u84c4\u7a4d\u304c\u59cb\u307e\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u65e9\u671f\u5bfe\u7b56\u306b\u3064\u3044\u3066\u306f \u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u89aa\u304c\u7cd6\u5c3f\u75c5\u3060\u3068\u81ea\u5206\u3082\uff1f\uff5c\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u4eba\u306e\u65e9\u671f\u5bfe\u7b56\u30fb\u62e1\u5927\u8102\u8cea\u691c\u67fb\u30fbFH\u3092\u89e3\u8aac\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/div>\n

3-3. \u30d5\u30ec\u30a4\u30eb\uff08\u865a\u5f31\uff09\u30fb\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\uff08\u7b4b\u8089\u6e1b\u5c11\u75c7\uff09<\/h3>\n
\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aRotterdam Study\uff082022\u5e74\uff09<\/p>\n

Waqas\u3089\u306f\u3001Rotterdam Study\u306e2,521\u540d<\/strong>\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6a2a\u65ad\u7814\u7a76\u3067\u3001SAF\u3067\u8a55\u4fa1\u3057\u305fAGEs\u84c4\u7a4d\u91cf\u304c\u30d5\u30ec\u30a4\u30eb\uff08Fried\u57fa\u6e96\u30fbRockwood\u30d5\u30ec\u30a4\u30eb\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\u53cc\u65b9\uff09\u3068\u6709\u610f\u306b\u95a2\u9023<\/strong>\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08J Gerontol A Biol Sci Med Sci, 2022\uff09\u3002\u30d5\u30ec\u30a4\u30eb\u306e\u7a0b\u5ea6\u304c\u91cd\u3044\u307b\u3069SAF\u5024\u306f\u9ad8\u304f\u3001\u3053\u306e\u95a2\u9023\u306f\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a<\/strong>\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/div>\n

\u540c\u3058\u304fRotterdam Study\u306e2,744\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u7814\u7a76\uff08J Clin Endocrinol Metab, 2022\uff09\u3067\u306f\u3001SAF\u5024\u304c\u6700\u3082\u9ad8\u3044\u7fa4\uff08\u7b2c4\u56db\u5206\u4f4d\uff09\u306f\u6700\u3082\u4f4e\u3044\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u63e1\u529b\u4f4e\u4e0b\uff08\u7b4b\u529b\u4f4e\u4e0b\uff09<\/strong>\u3084\u9aa8\u683c\u7b4b\u91cf\u4f4e\u4e0b<\/strong>\u306e\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u9ad8\u304f\u3001\u78ba\u5b9a\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u306e\u6709\u75c5\u7387\u3082\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002AGEs\u304c\u7b4b\u8089\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u67b6\u6a4b\u3092\u5f62\u6210\u3057\u3001\u7b4b\u8089\u306e\u8cea\u3068\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u9ad8\u9f62\u8005\u306e\u8ee2\u5012\u30ea\u30b9\u30af<\/strong>\u3068\u306e\u95a2\u9023\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001AGEs\u84c4\u7a4d\u306b\u3088\u308a\u7b4b\u529b\u3084\u8eab\u4f53\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u8ee2\u5012\u306e\u4e00\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u5fc3\u81d3\u624b\u8853\u60a3\u8005\u306b\u304a\u3051\u308b\u8853\u524d\u30d5\u30ec\u30a4\u30eb\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3082AGEs\u6e2c\u5b9a\u306e\u6709\u7528\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

3-4. \u3046\u3064\u75c5\uff08\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\uff09<\/h3>\n
\n

\u30a8\u30d3\u30c7\u30f3\u30b9\uff1aHelsinki Birth Cohort Study\uff082021\u5e74\uff09<\/p>\n

Eriksson\u3089\u306f\u3001Helsinki Birth Cohort Study\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u306b\u3001SAF\u3067\u6e2c\u5b9a\u3057\u305fAGEs\u5024\u3068\u3046\u3064\u75c7\u72b6\uff08Beck Depression Inventory\uff09\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\uff08J Psychosom Res, 2021\uff09\u3002\u305d\u306e\u7d50\u679c\u3001\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\u3046\u3064\u75c7\u72b6\u3092\u6709\u3059\u308b\u7fa4\u306eAGEs\u5024\uff082.61 AU\uff09<\/strong>\u306f\u3001\u975e\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\uff082.45 AU\uff09\u3001\u3046\u3064\u75c7\u72b6\u306a\u3057\u7fa4\uff082.38 AU\uff09\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u9ad8\u5024<\/strong>\u3067\u3057\u305f\uff08p = 0.013\uff09\u3002AGEs\u306b\u3088\u308b\u6162\u6027\u708e\u75c7\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u3001\u8133\u5185\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n

\u3055\u3089\u306b\u4e2d\u56fd\u306eREACTION\u7814\u7a76\uff084,420\u540d\u5bfe\u8c61\u30012023\u5e74\uff09\u3067\u306f\u3001SAF-AGEs\u306e\u56db\u5206\u4f4d\u5024\u304c\u4e0a\u6607\u3059\u308b\u306b\u3064\u308c\u3001\u3046\u3064\u75c7\u72b6\u306e\u30ea\u30b9\u30af\u304c\u30aa\u30c3\u30ba\u6bd41.24 \u2192 1.39 \u2192 1.57<\/strong>\u3068\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u4e0a\u6607\u3057\u3001\u3046\u3064\u75c7\u72b6\u306e\u91cd\u75c7\u5ea6\u3068\u3082\u6b63\u306e\u95a2\u9023\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

3-5. \u9aa8\u7c97\u9b06\u75c7\u30fb\u9aa8\u6298\u30ea\u30b9\u30af<\/h3>\n

\u9aa8\u306e\u7d0450%\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002AGEs\u304c\u3053\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u67b6\u6a4b\u3092\u5f62\u6210\u3059\u308b\u3068\u3001\u9aa8\u306e\u3057\u306a\u3084\u304b\u3055\u304c\u5931\u308f\u308c\u3001\u9aa8\u8cea\u304c\u52a3\u5316<\/strong>\u3057\u307e\u3059\u3002\u9aa8\u5bc6\u5ea6\uff08BMD\uff09\u304c\u6b63\u5e38\u3067\u3042\u3063\u3066\u3082\u3001AGEs\u84c4\u7a4d\u306b\u3088\u308a\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u30b1\u30fc\u30b9\u304c\u3042\u308a\u3001\u3053\u308c\u306f\u5f93\u6765\u306e\u9aa8\u5bc6\u5ea6\u691c\u67fb\u3060\u3051\u3067\u306f\u6349\u3048\u304d\u308c\u306a\u3044\u300c\u9aa8\u8cea\u306e\u554f\u984c\u300d\u3067\u3059\u3002AGE\u5316\u3057\u305f\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3092\u751f\u6210\u3057\u3001\u9aa8\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u6b7b\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002Rotterdam Study\u3067\u306f\u3001SAF\u9ad8\u5024\u304c\u690e\u4f53\u9aa8\u6298\u304a\u3088\u3073\u4e3b\u8981\u9aa8\u7c97\u9b06\u75c7\u6027\u9aa8\u6298\u306e\u6709\u75c5<\/strong>\u3068\u6709\u610f\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08J Bone Miner Res, 2020\uff09\u3002<\/p>\n

3-6. \u8a8d\u77e5\u75c7\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff09<\/h3>\n

\u8133\u5185\u306bAGEs\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001\u30a2\u30df\u30ed\u30a4\u30c9β\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u304c\u4fc3\u9032\u3055\u308c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002AGEs\u306b\u3088\u308b\u6162\u6027\u795e\u7d4c\u708e\u75c7\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u30fb\u8131\u843d\u3092\u52a0\u901f\u3055\u305b\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3055\u308c\u308b\u80cc\u666f\u306b\u306f\u3001\u3053\u306e\u7cd6\u5316\u7d4c\u8def\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

3-7. \u76ae\u819a\u306e\u8001\u5316<\/h3>\n

\"AGEs\u3068\u76ae\u819a\u8001\u5316\"<\/p>\n

\u76ae\u819a\u3092\u69cb\u6210\u3059\u308b\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306bAGEs\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001\u5f3e\u529b\u6027\u306e\u55aa\u5931<\/strong>\uff08\u3057\u308f\u30fb\u305f\u308b\u307f\uff09\u3001\u9ec4\u8910\u8272\u306e\u304f\u3059\u307f<\/strong>\uff08\u7cd6\u5316\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\uff09\u304c\u9032\u884c\u3057\u307e\u3059\u3002\u307e\u305fAGEs\u304c\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u523a\u6fc0\u3057\u3066\u30b7\u30df\u306e\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u9ad8\u5ea6\u80a5\u6e80\u8005\u3067\u306f\u76ae\u819a\u306eAGEs\u84c4\u7a4d\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

3-8. \u305d\u306e\u4ed6\u306e\u95a2\u9023<\/h3>\n

\u3055\u3089\u306b\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u591a\u5f69\u306a\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\n

AGEs\u306b\u95a2\u3059\u308b\u591a\u9818\u57df\u306e\u6700\u65b0\u7814\u7a76\u77e5\u898b<\/p>\n

\u8033\u305f\u3076\u306e\u3057\u308f\uff08Frank\u5fb4\u5019\uff09\u3068\u306e\u95a2\u9023<\/strong>\uff1a\u8033\u305f\u3076\u306e\u5bfe\u89d2\u7dda\u72b6\u306e\u3057\u308f\u306f\u52d5\u8108\u786c\u5316\u306e\u30b5\u30a4\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u304a\u308a\u3001AGEs\u84c4\u7a4d\u3068\u306e\u95a2\u9023\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8033\u305f\u3076\u306e\u3057\u308f\u304c\u3042\u308b\u60a3\u8005\u3067\u306f\u8001\u5316\u6291\u5236\u30db\u30eb\u30e2\u30f3Klotho\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4f4e\u304f\u3001\u8840\u7ba1\u8001\u5316\u306e\u9032\u884c\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u7761\u7720\u6642\u9593\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af<\/strong>\uff1a\u7761\u7720\u4e0d\u8db3\u306f\u4f53\u5185\u306e\u7cd6\u4ee3\u8b1d\u3092\u60aa\u5316\u3055\u305b\u3001AGEs\u84c4\u7a4d\u3092\u4fc3\u9032\u3002\u77ed\u6642\u9593\u7761\u7720\u8005\u3067\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5c0f\u5150\u306b\u304a\u3051\u308b\u8eab\u4f53\u6d3b\u52d5\u3068\u306e\u95a2\u4fc2<\/strong>\uff1a\u904b\u52d5\u91cf\u304c\u5c11\u306a\u3044\u5c0f\u5150\u3067\u306fAGEs\u84c4\u7a4d\u304c\u9032\u884c\u3057\u3084\u3059\u304f\u3001\u82e5\u5e74\u671f\u304b\u3089\u306e\u751f\u6d3b\u7fd2\u6163\u306e\u91cd\u8981\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u767d\u8840\u7403\uff08\u597d\u4e2d\u7403\u30fb\u5358\u7403\uff09\u3068\u306e\u95a2\u9023<\/strong>\uff1a\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u3068\u8840\u4e2d\u597d\u4e2d\u7403\u6570\u30fb\u5358\u7403\u6570\u304c\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u3001AGEs\u84c4\u7a4d\u304c\u6162\u6027\u708e\u75c7\u72b6\u614b\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u88cf\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u767d\u5185\u969c\u30fb\u7db2\u819c\u75c7<\/strong>\uff1a\u6c34\u6676\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30af\u30ea\u30b9\u30bf\u30ea\u30f3\uff09\u306eAGEs\u5316\u306f\u767d\u5185\u969c\u306e\u4e3b\u8981\u56e0\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n<\/div>\n

\n

4. AGEs\u3092\u5897\u3084\u3059\u751f\u6d3b\u7fd2\u6163 \u2015 1\u4e071,000\u4eba\u306e\u65e5\u672c\u4eba\u8abf\u67fb\u304b\u3089<\/h2>\n

\"AGEs\u3068\u751f\u6d3b\u7fd2\u6163\"<\/p>\n

\u82b1\u738b\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u4f1a\u304c\u5168\u56fd\u7d041\u4e071,000\u4eba\u306e\u65e5\u672c\u4eba<\/strong>\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3057\u305f\u8abf\u67fb\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u751f\u6d3b\u7fd2\u6163\u304c\u5e74\u9f62\u3068\u306f\u72ec\u7acb\u3057\u3066<\/strong>\u76ae\u819aAGEs\u84c4\u7a4d\u91cf\u306e\u4e0a\u6607\u3068\u6709\u610f\u306b\u76f8\u95a2\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\n

AGEs\u3092\u5897\u52a0\u3055\u305b\u308b6\u3064\u306e\u751f\u6d3b\u7fd2\u6163\u30ea\u30b9\u30af\u56e0\u5b50<\/p>\n

1. \u55ab\u7159<\/strong>\uff1a\u30bf\u30d0\u30b3\u7159\u306b\u542b\u307e\u308c\u308bAGEs\u304c\u80ba\u304b\u3089\u5438\u53ce\u3002\u55ab\u7159\u8005\u306f\u975e\u55ab\u7159\u8005\u3088\u308a\u8840\u4e2d\u30fb\u76ae\u819a\u4e2dAGEs\u6fc3\u5ea6\u304c\u6709\u610f\u306b\u9ad8\u5024<\/p>\n

2. \u904b\u52d5\u4e0d\u8db3<\/strong>\uff1a\u904b\u52d5\u306b\u3088\u308b\u8840\u7cd6\u6d88\u8cbb\u306e\u4f4e\u4e0b\u304cAGEs\u751f\u6210\u3092\u4fc3\u9032<\/p>\n

3. \u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9<\/strong>\uff1a\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306b\u3088\u308b\u8840\u7cd6\u4e0a\u6607\u304cAGEs\u751f\u6210\u306b\u5bc4\u4e0e<\/p>\n

4. \u7761\u7720\u4e0d\u8db3<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u4f4e\u4e0b\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u6e1b\u5c11\u3092\u4ecb\u3057\u3066AGEs\u84c4\u7a4d\u3092\u4fc3\u9032<\/p>\n

5. \u671d\u98df\u629c\u304d<\/strong>\uff1a\u6b21\u306e\u98df\u4e8b\u3067\u306e\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u304c\u5897\u5927\u3057\u3001AGEs\u751f\u6210\u304c\u4fc3\u9032<\/p>\n

6. \u7518\u3044\u7269\u30fb\u52a0\u5de5\u8089\u30fb\u63da\u3052\u7269\u306e\u904e\u5270\u6442\u53d6<\/strong>\uff1a\u5916\u56e0\u6027AGEs\u306e\u76f4\u63a5\u7684\u306a\u6442\u53d6\u6e90<\/p>\n<\/div>\n

AGEs\u30b9\u30b3\u30a2\u306f\u300c\u751f\u6d3b\u7fd2\u6163\u306e\u6210\u7e3e\u8868\u300d\u3067\u3059\u3002\u4e0a\u8a18\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u306f\u4e00\u3064\u3072\u3068\u3064\u306f\u5c0f\u3055\u304f\u898b\u3048\u3066\u3082\u3001\u8907\u5408\u7684\u306b\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u8001\u5316\u3092\u5927\u304d\u304f\u52a0\u901f\u3055\u305b\u307e\u3059\u3002<\/p>\n

\n

5. AGEs\u84c4\u7a4d\u3092\u9632\u30507\u3064\u306e\u5b9f\u8df5\u7684\u5bfe\u7b56<\/h2>\n
\n

📖 \u5b9f\u8df5\u7de8\u306f\u3053\u3061\u3089\uff1a<\/strong>\u672c\u8a18\u4e8b\u3067\u306f7\u3064\u306e\u5bfe\u7b56\u3092\u8981\u70b9\u3067\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3088\u308a\u8a73\u3057\u3044\u5b9f\u8df5\u30ac\u30a4\u30c9\uff08\u5177\u4f53\u7684\u306a\u8abf\u7406\u6cd5\u3001\u9ad8AGE\/\u4f4eAGE\u98df\u54c1\u30ea\u30b9\u30c8\u3001\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528\u3001\u5f53\u9662\u3067\u306e\u500b\u5225\u5316\u30a2\u30d7\u30ed\u30fc\u30c1\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u300c\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7cd6\u5316\uff09\u5bfe\u7b56\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9\uff5c\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u30fb\u85ac\u5264\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8001\u5316\u3068\u5408\u4f75\u75c7\u3092\u9632\u3050\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/div>\n

\"AGEs\u5bfe\u7b56\"<\/p>\n

\u5bfe\u7b561\uff1a\u8abf\u7406\u6cd5\u3092\u5de5\u592b\u3059\u308b \u2015 \u300c\u713c\u304f\u30fb\u63da\u3052\u308b\u300d\u3088\u308a\u300c\u716e\u308b\u30fb\u84b8\u3059\u300d<\/h3>\n

\u9ad8\u6e29\u8abf\u7406\u306fAGEs\u751f\u6210\u3092\u6307\u6570\u95a2\u6570\u7684\u306b\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u63da\u3052\u7269\uff08170\uff5e200\u2103\uff09\u3084\u30aa\u30fc\u30d6\u30f3\u713c\u304d\uff08200\u2103\u4ee5\u4e0a\uff09\u306b\u5bfe\u3057\u3001\u8339\u3067\u308b\u30fb\u84b8\u3059\u30fb\u716e\u308b\u8abf\u7406\u6cd5\u306f100\u2103\u7a0b\u5ea6\u306b\u3068\u3069\u307e\u308a\u3001AGEs\u751f\u6210\u3092\u5927\u5e45\u306b\u6291\u5236\u3067\u304d\u307e\u3059\u3002\u540c\u3058\u9d8f\u3080\u306d\u8089\u3067\u3082\u3001\u713c\u304d\u9ce5\uff08\u76f4\u706b\u713c\u304d\uff09\u306f\u6c34\u708a\u304d\u306e\u7d045\uff5e10\u500d\u306eAGEs\u3092\u542b\u307f\u307e\u3059\u3002\u9162\u3084\u30ec\u30e2\u30f3\u6c41\u306a\u3069\u9178\u6027\u306e\u8abf\u5473\u6599\u3092\u4f7f\u3063\u305f\u30de\u30ea\u30cd\u3082AGEs\u751f\u6210\u306e\u6291\u5236\u306b\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n

\u5bfe\u7b562\uff1a\u98df\u3079\u308b\u9806\u756a\u3092\u5b88\u308b \u2015 \u30d9\u30b8\u30bf\u30d6\u30eb\u30d5\u30a1\u30fc\u30b9\u30c8<\/h3>\n

\u98df\u7269\u7e4a\u7dad<\/strong>\uff08\u91ce\u83dc\u30fb\u6d77\u85fb\u30fb\u304d\u306e\u3053\u985e\uff09\u2192 \u30bf\u30f3\u30d1\u30af\u8cea<\/strong>\uff08\u8089\u30fb\u9b5a\uff09\u2192 \u70ad\u6c34\u5316\u7269<\/strong>\uff08\u3054\u306f\u3093\u30fb\u30d1\u30f3\uff09\u306e\u9806\u756a\u3067\u98df\u3079\u308b\u3053\u3068\u3067\u3001\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u6291\u3048\u3001AGEs\u751f\u6210\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002\u3086\u3063\u304f\u308a\u3088\u304f\u565b\u3093\u3067\u98df\u3079\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n

\u5bfe\u7b563\uff1a\u4f4eGI\u98df\u54c1\u3092\u9078\u3076<\/h3>\n

GI\u5024\uff08Glycemic Index\uff1a\u98df\u54c1\u306e\u8840\u7cd6\u4e0a\u6607\u6307\u6570\uff09\u304c55\u4ee5\u4e0b\u306e\u4f4eGI\u98df\u54c1\u3092\u9078\u3076\u3053\u3068\u3067\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u3092\u9632\u304e\u307e\u3059\u3002\u5927\u8c46\u88fd\u54c1\u3001\u5168\u7c92\u7a40\u7269\u3001\u30ca\u30c3\u30c4\u985e\u306a\u3069\u304c\u4ee3\u8868\u7684\u306a\u4f4eGI\u98df\u54c1\u3067\u3059\u3002<\/p>\n

\u5bfe\u7b564\uff1a\u98df\u5f8c\u306e\u904b\u52d5\u3092\u7fd2\u6163\u306b<\/h3>\n

\u98df\u5f8c20\uff5e30\u5206\u306e\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3067\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u7a4f\u3084\u304b\u306b\u3057\u3001AGEs\u751f\u6210\u3092\u6291\u5236\u3067\u304d\u307e\u3059\u3002\u8840\u7cd6\u5024\u304c\u6700\u3082\u4e0a\u304c\u308b\u306e\u306f\u98df\u5f8c\u7d041\u6642\u9593\u3067\u3042\u308a\u3001\u3053\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u306e\u904b\u52d5\u304c\u52b9\u679c\u7684\u3067\u3059\u3002\u5bb6\u4e8b\u306a\u3069\u3067\u4f53\u3092\u52d5\u304b\u3059\u3053\u3068\u3067\u3082\u5341\u5206\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u5bfe\u7b565\uff1a\u6297\u9178\u5316\u7269\u8cea\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b<\/h3>\n

\u300c\u9178\u5316\u300d\u3068\u300c\u7cd6\u5316\u300d\u306f\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u540c\u6642\u306b\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u9178\u5316\u3057\u305f\u8102\u8cea\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306fAGEs\u306b\u5909\u5316\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u6297\u9178\u5316\u7269\u8cea\u306e\u6442\u53d6<\/strong>\u304c\u7cd6\u5316\u6291\u5236\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u7dd1\u9ec4\u8272\u91ce\u83dc\uff08\u7279\u306b\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u3001\u307b\u3046\u308c\u3093\u8349\u3001\u30c8\u30de\u30c8\uff09\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u30b9\u30d7\u30e9\u30a6\u30c8\u3001\u30de\u30a4\u30bf\u30b1\u306a\u3069\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306b\u3082AGEs\u84c4\u7a4d\u6291\u5236\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5bfe\u7b566\uff1a\u5341\u5206\u306a\u7761\u7720\u3068\u7981\u7159<\/h3>\n

\u8cea\u306e\u9ad8\u3044\u7761\u7720\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u7dad\u6301\u3057\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067AGEs\u84c4\u7a4d\u3092\u6291\u5236\u3057\u307e\u3059\u3002\u7981\u7159\u306fAGEs\u306e\u5916\u56e0\u6027\u4f9b\u7d66\u3092\u65ad\u3064\u6700\u3082\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n

\u5bfe\u7b567\uff1a\u5b9a\u671f\u7684\u306aAGEs\u6e2c\u5b9a\u3067\u300c\u898b\u3048\u308b\u5316\u300d<\/h3>\n

AGEs\u6e2c\u5b9a\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u3001\u3054\u81ea\u8eab\u306e\u8001\u5316\u5ea6\u30fb\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u5ea6\u3092\u5ba2\u89b3\u7684\u306b\u628a\u63e1\u3067\u304d\u307e\u3059\u3002\u300c\u898b\u3048\u308b\u5316\u300d\u3059\u308b\u3053\u3068\u304c\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u306e\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u7dad\u6301\u306b\u7e4b\u304c\u308a\u307e\u3059\u3002<\/p>\n

\"\u6297\u9178\u5316\u7269\u8cea\"<\/p>\n

\u5f53\u9662\u306e\u7ba1\u7406\u6804\u990a\u58eb\u304c\u3001AGEs\u5bfe\u7b56\u306b\u52b9\u679c\u7684\u306a\u30ec\u30b7\u30d4\u3092\u516c\u958b\u3057\u3066\u3044\u307e\u3059\u3002\u305c\u3072\u53c2\u8003\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u7ba1\u7406\u6804\u990a\u58eb\u304a\u3059\u3059\u3081\u30ec\u30b7\u30d4\u306f\u3053\u3061\u3089 \u2192<\/strong><\/a><\/p>\n

\n

6. \u5f53\u9662\u306eAGEs\u6e2c\u5b9a\u691c\u67fb\u306b\u3064\u3044\u3066<\/h2>\n

\"AGEs\u6e2c\u5b9a\u5668\"<\/p>\n

\u691c\u67fb\u306e\u539f\u7406\uff1a\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08SAF\uff09\u6e2c\u5b9a<\/h3>\n

\u5f53\u9662\u306eAGEs\u6e2c\u5b9a\u306f\u3001\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08Skin Autofluorescence\uff1aSAF\uff09<\/strong>\u3092\u5229\u7528\u3057\u305f\u975e\u4fb5\u8972\u7684\u306a\u691c\u67fb\u3067\u3059\u3002\u76ae\u819a\u306b\u7279\u5b9a\u306e\u6ce2\u9577\uff08300\uff5e420nm\uff09\u306e\u7d2b\u5916\u5149\u3092\u7167\u5c04\u3059\u308b\u3068\u3001\u7d44\u7e54\u4e2d\u306b\u84c4\u7a4d\u3057\u305f\u86cd\u5149\u6027AGEs\uff08\u4e3b\u306b\u30da\u30f3\u30c8\u30b7\u30b8\u30f3\uff09\u304c420\uff5e600nm\u306e\u86cd\u5149\u3092\u767a\u3057\u307e\u3059\u3002\u3053\u306e\u86cd\u5149\u5f37\u5ea6\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u3067\u3001\u304a\u304a\u3088\u305d\u306eAGEs\u84c4\u7a4d\u91cf\u3092\u63a8\u5b9a\u3057\u307e\u3059\u3002\u76ae\u819a\u751f\u691c\u3067\u8a55\u4fa1\u3057\u305fAGEs\u91cf\u3068\u306e\u76f8\u95a2\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u691c\u67fb\u6cd5\u3067\u3059\u3002<\/p>\n

\n

\u691c\u67fb\u6982\u8981<\/p>\n

\u691c\u67fb\u65b9\u6cd5<\/strong>\uff1a\u8155\u3092\u6e2c\u5b9a\u5668\u306b\u4e57\u305b\u308b\u3060\u3051\uff08\u63a1\u8840\u4e0d\u8981\uff09<\/p>\n

\u6240\u8981\u6642\u9593<\/strong>\uff1a\u7d0412\u79d2<\/p>\n

AGEs\u6e2c\u5b9a<\/strong>\uff1a1,000\u5186\uff08\u7a0e\u8fbc\uff09<\/strong><\/p>\n

\u203b\u5225\u9014\u3001\u8a3a\u5bdf\u65993,000\u5186\uff08\u7a0e\u8fbc\uff09<\/strong>\u304c\u304b\u304b\u308a\u307e\u3059<\/p>\n

\u75db\u307f<\/strong>\uff1a\u306a\u3057\uff08\u5b8c\u5168\u975e\u4fb5\u8972\uff09<\/p>\n

\u5bfe\u8c61<\/strong>\uff1a\u5e74\u9f62\u3092\u554f\u308f\u305a\u3069\u306a\u305f\u3067\u3082\u6e2c\u5b9a\u53ef\u80fd<\/p>\n<\/div>\n

\u5b9a\u671f\u7684\u306b\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u3069\u306e\u7a0b\u5ea6\u8001\u5316\u304c\u9032\u3093\u3067\u3044\u308b\u304b\u3001\u307e\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u52b9\u679c\u304c\u3069\u306e\u7a0b\u5ea6\u73fe\u308c\u3066\u3044\u308b\u304b\u306e\u6307\u6a19\u306b\u306a\u308a\u307e\u3059\u3002AGEs\u30b9\u30b3\u30a2\u3092\u3046\u307e\u304f\u6d3b\u7528\u3057\u3066\u3001\u5065\u5eb7\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u3092\u5fc3\u639b\u3051\u307e\u3057\u3087\u3046\u3002<\/p>\n

\n

💡 \u691c\u67fb\u7d50\u679c\u304c\u9ad8\u304b\u3063\u305f\u65b9\u3078\uff1a<\/strong>\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u5024\u304c\u5e74\u9f62\u76f8\u5f53\u3088\u308a\u9ad8\u304b\u3063\u305f\u65b9\u306b\u306f\u3001AGEs\u5bfe\u7b56\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9<\/strong><\/a>\u3067\u5177\u4f53\u7684\u306a\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u306e\u4ecb\u5165\u65b9\u6cd5\u3092\u3054\u78ba\u8a8d\u3044\u305f\u3060\u304d\u30013\u301c6\u304b\u6708\u5f8c\u306e\u518d\u6e2c\u5b9a\u3067\u6539\u5584\u3092\u5ba2\u89b3\u7684\u306b\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u30fb\u524d\u7cd6\u5c3f\u75c5\u306e\u65b9\u306f\u85ac\u5264\u306b\u3088\u308b\u6297\u7cd6\u5316\u30a2\u30d7\u30ed\u30fc\u30c1\u3082\u4e00\u7dd2\u306b\u691c\u8a0e\u3057\u307e\u3059\u3002<\/p>\n<\/div>\n

d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30fbd-Gs\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\u306e\u3054\u6848\u5185<\/h3>\n

\u5f53\u9662\u3067\u306f\u3001\u3010d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3011\u3010d-Gs\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\u3011\u306e\u8ca9\u58f2<\/strong><\/a>\u3092\u958b\u59cb\u3044\u305f\u3057\u307e\u3057\u305f\u3002\u8a73\u7d30\u306f\u3053\u3061\u3089<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n

\"d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30fb\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\"<\/a><\/p>\n

\n

7. \u53c2\u8003\u6587\u732e\u30fb\u5f15\u7528\u7814\u7a76<\/h2>\n
\n

1. Waqas K, et al. Skin Autofluorescence, a Noninvasive Biomarker of Advanced Glycation End-products, Is Associated With Frailty: The Rotterdam Study. J Gerontol A Biol Sci Med Sci<\/em>. 2022;77(10):2032-2039.<\/p>\n

2. Waqas K, et al. Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Sarcopenia. J Clin Endocrinol Metab<\/em>. 2022;107(2):e793-e803.<\/p>\n

3. Eriksson MD, et al. Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study. J Psychosom Res<\/em>. 2021;146:110504.<\/p>\n

4. de Vos LC, et al. Skin autofluorescence is associated with 5-year mortality and cardiovascular events in patients with peripheral artery disease. Arterioscler Thromb Vasc Biol<\/em>. 2014;34(4):933-938.<\/p>\n

5. Waqas K, et al. Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Prevalent Vertebral and Major Osteoporotic Fractures: The Rotterdam Study. J Bone Miner Res<\/em>. 2020;35(10):1904-1913.<\/p>\n

6. Pilleron S, et al. Accumulation of advanced glycation end products evaluated by skin autofluorescence and incident frailty in older adults from the Bordeaux Three-City cohort. PLoS One<\/em>. 2017;12(10):e0186087.<\/p>\n

7. Meerwaldt R, et al. Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. Diabetologia<\/em>. 2004.<\/p>\n

8. \u5c71\u5cb8\u660c\u4e00. \u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u5024\u6e2c\u5b9a\u306e\u81e8\u5e8a\u7684\u610f\u7fa9. Diabetes Frontier Online<\/em>.<\/p>\n

9. Uribarri J, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc<\/em>. 2010;110(6):911-916.e12.<\/p>\n<\/div>\n

\n

\u95a2\u9023\u8a18\u4e8b<\/h2>\n\n\n\n
\n

AGE\u5bfe\u7b56\u30fb\u5b9f\u8df5\u7de8<\/p>\n

\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7cd6\u5316\uff09\u5bfe\u7b56\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9\uff5c\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u30fb\u85ac\u5264\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8001\u5316\u3068\u5408\u4f75\u75c7\u3092\u9632\u3050<\/a><\/p>\n

\u8abf\u7406\u6cd5\u30fb\u98df\u6750\u9078\u3073\u30fb\u98df\u5f8c\u8840\u7cd6\u7ba1\u7406\u30fb\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528\u307e\u3067\u3092\u4f53\u7cfb\u7684\u306b\u89e3\u8aac<\/p>\n<\/td>\n

\n

\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda<\/p>\n

\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\uff5c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u30fbCGM\u500b\u5225\u5316\uff0b\u6297\u8001\u5316\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9<\/a><\/p>\n

\u7cd6\u5c3f\u75c5\u85ac\u306e\u9078\u629e\u30fbCGM\u306b\u3088\u308b\u500b\u5225\u5316\u30fbGeroscience\uff08\u8001\u5316\u533b\u79d1\u5b66\uff09\u306e\u8996\u70b9<\/p>\n<\/td>\n<\/tr>\n

\n

\u30e1\u30bf\u30dc\u2192\u7cd6\u5c3f\u75c5\u306e\u9032\u884c<\/p>\n

\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\uff5c2024\u5e74\u65b0\u57fa\u6e96\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3092\u5fb9\u5e95\u89e3\u8aac<\/a><\/p>\n

\u5185\u81d3\u8102\u80aa\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3068AGE\u84c4\u7a4d\u306e\u60aa\u5faa\u74b0<\/p>\n<\/td>\n

\n

\u7cd6\u5c3f\u75c5\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u65b9\u3078<\/p>\n

\u3010\u533b\u5e2b\u76e3\u4fee\u3011\u89aa\u304c\u7cd6\u5c3f\u75c5\u3060\u3068\u81ea\u5206\u3082\uff1f\uff5c\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u4eba\u306e\u65e9\u671f\u5bfe\u7b56\u30fb\u62e1\u5927\u8102\u8cea\u691c\u67fb\u30fbFH\u3092\u89e3\u8aac<\/a><\/p>\n

\u5bb6\u65cf\u6b74\u306e\u3042\u308b\u65b9\u306e\u65e9\u671f\u5bfe\u7b56\u3001\u62e1\u5927\u8102\u8cea\u691c\u67fb\u3001\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff08FH\uff09<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

<\/p>\n

\n
\n
GORYOKAI GROUP<\/div>\n
\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662<\/div>\n<\/p><\/div>\n
\n\n\n\n
\u5185\u79d1<\/td>\n\u5c0f\u5150\u79d1<\/td>\n\u7cd6\u5c3f\u75c5\u5185\u79d1<\/td>\n\u4ee3\u8b1d\u5185\u79d1<\/td>\n\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/td>\n<\/tr>\n
\u76ae\u819a\u79d1<\/td>\n\u751f\u6d3b\u7fd2\u6163\u75c5<\/td>\n\u8a2a\u554f\u8a3a\u7642<\/td>\n\u5fc3\u7642\u5185\u79d1<\/td>\n\u5065\u5eb7\u8a3a\u65ad<\/td>\n<\/tr>\n<\/table>\n

\u3012145-0072 \u6771\u4eac\u90fd\u5927\u7530\u533a\u7530\u5712\u8abf\u5e03\u672c\u753a40-12 \u30b3\u30f3\u30c9\u7530\u5712\u8abf\u5e03\uff12\u968e<\/p>\n

\u6771\u6025\u6771\u6a2a\u7dda\u30fb\u76ee\u9ed2\u7dda\u3000\u591a\u6469\u5ddd\u99c5 \u5f92\u6b695\u5206<\/p>\n

\u571f\u66dc\u5348\u524d\u3082\u8a3a\u7642<\/div>\n\n\n\n\n\n\n
\u8a3a\u7642\u6642\u9593<\/th>\n\u6708<\/th>\n\u706b<\/th>\n\u6c34<\/th>\n\u6728<\/th>\n\u91d1<\/th>\n\u571f<\/th>\n\u65e5\u795d<\/th>\n<\/tr>\n<\/thead>\n
\u5348\u524d
9:00-12:00<\/td>\n		\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u4f11<\/td>\n<\/tr>\n
\u5348\u5f8c
15:30-19:00<\/td>\n		\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u25cb<\/td>\n\u4f11<\/td>\n\u4f11<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n
\n
\n \"CLINICS\"
\n WEB\u4e88\u7d04<\/span>
\n <\/a>\n <\/td>\n		\n
\n \"melmo\"
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