{"id":2137,"date":"2026-05-10T20:45:00","date_gmt":"2026-05-10T11:45:00","guid":{"rendered":"https:\/\/www.takeuchi-iin.jp\/blog\/?p=2137"},"modified":"2026-05-21T22:41:25","modified_gmt":"2026-05-21T13:41:25","slug":"ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83","status":"publish","type":"post","link":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/","title":{"rendered":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185"},"content":{"rendered":"<p>\u7686\u3055\u307e\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u306e\u4e94\u85e4\u826f\u5c06\u3067\u3059\u3002<\/p>\n<p>\u300c\u6700\u8fd1\u3001\u304a\u808c\u306e\u304f\u3059\u307f\u3084\u75b2\u308c\u3084\u3059\u3055\u304c\u6c17\u306b\u306a\u308b\u300d\u300c\u7cd6\u5c3f\u75c5\u3060\u3068\u8a00\u308f\u308c\u3066\u3001\u5408\u4f75\u75c7\u304c\u5fc3\u914d\u300d\u300c\u4e21\u89aa\u304c\u8a8d\u77e5\u75c7\u3084\u9aa8\u7c97\u9b06\u75c7\u3067\u3001\u81ea\u5206\u306e\u8001\u5316\u3082\u6c17\u306b\u306a\u308a\u59cb\u3081\u305f\u300d\u2014\u2014\u3053\u3046\u3057\u305f\u304a\u60a9\u307f\u306b\u5171\u901a\u3059\u308b\u30ad\u30fc\u30ef\u30fc\u30c9\u304c<strong>AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff1aAdvanced Glycation End-products\uff09<\/strong>\u3001\u3044\u308f\u3086\u308b<strong>\u300c\u4f53\u306e\u7126\u3052\u3064\u304d\u300d<\/strong>\u3067\u3059\u3002<\/p>\n<p>2025\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u5927\u898f\u6a21\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08<em>European Journal of Medical Research<\/em>\u3001<em>Clinical Research in Cardiology<\/em>\uff09\u3067\u306f\u3001<strong>\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08Skin Autofluorescence\uff1aSAF\uff09<\/strong>\u3067\u6e2c\u5b9a\u3057\u305fAGEs\u84c4\u7a4d\u91cf\u304c\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u30fb\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u30fb\u6162\u6027\u814e\u81d3\u75c5\u60a3\u8005\u306e\u3044\u305a\u308c\u306b\u304a\u3044\u3066\u3082<strong>\u5168\u6b7b\u4ea1\u30fb\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u30fb\u8133\u5352\u4e2d\u306e\u72ec\u7acb\u3057\u305f\u4e88\u6e2c\u56e0\u5b50<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u6539\u3081\u3066\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002AGEs\u306f\u3082\u306f\u3084\u300c\u7f8e\u5bb9\u4e0a\u306e\u8001\u5316\u6307\u6a19\u300d\u3067\u306f\u306a\u304f\u3001\u751f\u547d\u4e88\u5f8c\u3092\u5de6\u53f3\u3059\u308b<strong>\u91cd\u8981\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/strong>\u3068\u3057\u3066\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5f53\u9662\u3067\u306f\u3001\u8155\u3092\u6e2c\u5b9a\u5668\u306b\u4e57\u305b\u308b\u3060\u3051\u306e\u7c21\u4fbf\u306a\u691c\u67fb\uff08\u7d0412\u79d2\u30fb\u63a1\u8840\u4e0d\u8981\uff09\u3067AGEs\u84c4\u7a4d\u91cf\u3092\u53ef\u8996\u5316\u3067\u304d\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u30012026\u5e74\u6642\u70b9\u3067\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u8e0f\u307e\u3048\u3001AGEs\u304c\u5168\u8eab\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3068\u3001\u305d\u306e\u5bfe\u7b56\u30fb\u5f53\u9662\u3067\u306e\u6e2c\u5b9a\u306e\u610f\u7fa9\u306b\u3064\u3044\u3066\u9662\u9577\u3068\u3057\u3066\u8a73\u3057\u304f\u89e3\u8aac\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-16.png\" alt=\"AGEs\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<div style=\"background: #f1f8f6; border: 1px solid #80cbc4; border-radius: 8px; padding: 22px 26px; margin: 30px 0;\">\n<p style=\"margin: 0 0 14px 0; font-weight: bold; color: #004d40; font-size: 1.15em; padding-bottom: 10px; border-bottom: 2px solid #00796b;\">\u76ee\u6b21<\/p>\n<ol style=\"margin: 0; padding-left: 24px; line-height: 2;\">\n<li><a href=\"#sec1\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3068\u306f\uff1f\u2014 \u7cd6\u5316\u53cd\u5fdc\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0<\/a><\/li>\n<li><a href=\"#sec2\" style=\"color: #00796b; text-decoration: none;\">AGEs\u306e2\u5927\u4f9b\u7d66\u7d4c\u8def \u2014 \u5185\u56e0\u6027\uff08\u9ad8\u8840\u7cd6\uff09\u3068\u5916\u56e0\u6027\uff08\u98df\u4e8b\u30fb\u55ab\u7159\uff09<\/a><\/li>\n<li><a href=\"#sec3\" style=\"color: #00796b; text-decoration: none;\">AGEs\u306f\u306a\u305c\u5371\u967a\u304b\uff1f\u2014 RAGE\u53d7\u5bb9\u4f53\u3068\u5168\u8eab\u3078\u306e\u5f71\u97ff<\/a><\/li>\n<li><a href=\"#sec4\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3068\u5fc3\u8840\u7ba1\u75be\u60a3 \u2014 2025\u5e74\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9<\/a><\/li>\n<li><a href=\"#sec5\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3068\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u30fb\u6162\u6027\u814e\u81d3\u75c5<\/a><\/li>\n<li><a href=\"#sec6\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3068\u30d5\u30ec\u30a4\u30eb\u30fb\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u9aa8\u7c97\u9b06\u75c7<\/a><\/li>\n<li><a href=\"#sec7\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3068\u8a8d\u77e5\u75c7\u30fb\u3046\u3064\u75c5 \u2014 \u8133\u3068\u3053\u3053\u308d\u3078\u306e\u5f71\u97ff<\/a><\/li>\n<li><a href=\"#sec8\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3068\u76ae\u819a\u8001\u5316\u30fb\u5c0f\u5150\u671f\u304b\u3089\u306e\u84c4\u7a4d\u30ea\u30b9\u30af<\/a><\/li>\n<li><a href=\"#sec9\" style=\"color: #00796b; text-decoration: none;\">AGEs\u3092\u5897\u3084\u30596\u3064\u306e\u751f\u6d3b\u7fd2\u6163 \u2014 1\u4e071\u5343\u4eba\u306e\u65e5\u672c\u4eba\u8abf\u67fb\u304b\u3089<\/a><\/li>\n<li><a href=\"#sec10\" style=\"color: #00796b; text-decoration: none;\">AGEs\u84c4\u7a4d\u3092\u9632\u30507\u3064\u306e\u5b9f\u8df5\u7684\u5bfe\u7b56<\/a><\/li>\n<li><a href=\"#sec11\" style=\"color: #00796b; text-decoration: none;\">\u5f53\u9662\u306eAGEs\u6e2c\u5b9a\u691c\u67fb\u30fbd-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/a><\/li>\n<li><a href=\"#sec12\" style=\"color: #00796b; text-decoration: none;\">\u3088\u304f\u3042\u308b\u3054\u8cea\u554f\uff08FAQ\uff09<\/a><\/li>\n<li><a href=\"#sec13\" style=\"color: #00796b; text-decoration: none;\">\u95a2\u9023\u8a18\u4e8b\u30fb\u30b0\u30eb\u30fc\u30d7\u5185\u9023\u643a<\/a><\/li>\n<li><a href=\"#sec_ref\" style=\"color: #00796b; text-decoration: none;\">\u53c2\u8003\u6587\u732e<\/a><\/li>\n<\/ol>\n<\/div>\n<hr \/>\n<h2 id=\"sec1\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">1. AGEs\u3068\u306f\uff1f\u2014 \u7cd6\u5316\u53cd\u5fdc\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2024\/04\/image-54-1.jpg\" alt=\"AGEs\u8aac\u660e\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2024\/04\/image-54-3.jpg\" alt=\"AGEs\u8aac\u660e2\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<p>AGEs\u3068\u306f\u3001\u4f53\u5185\u306e<strong>\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u8102\u8cea<\/strong>\u304c<strong>\u7cd6\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u3084\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u306a\u3069\uff09<\/strong>\u3068\u975e\u9175\u7d20\u7684\u306b\u7d50\u5408\u3057\u3066\u751f\u3058\u308b\u7269\u8cea\u306e\u7dcf\u79f0\u3067\u3059\u3002\u3053\u306e\u53cd\u5fdc\u306f<strong>\u300c\u30e1\u30a4\u30e9\u30fc\u30c9\u53cd\u5fdc\uff08\u7cd6\u5316\u53cd\u5fdc\uff09\u300d<\/strong>\u3068\u547c\u3070\u308c\u3001\u98df\u54c1\u3092\u52a0\u71b1\u3057\u305f\u969b\u306b\u3053\u3093\u304c\u308a\u3068\u3057\u305f\u713c\u304d\u8272\u304c\u3064\u304f\u73fe\u8c61\u3068\u540c\u3058\u5316\u5b66\u53cd\u5fdc\u304c\u3001\u4f53\u6e2937\u2103\u306e\u4f53\u5185\u3067\u3082\u3086\u3063\u304f\u308a\u3068\u9032\u884c\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<div style=\"background: #f3e5f5; border: 2px solid #7b1fa2; border-radius: 8px; padding: 20px 24px; margin: 25px 0;\">\n<p style=\"margin: 0 0 14px 0; font-weight: bold; color: #4a148c; font-size: 1.1em;\">\u30e1\u30ab\u30cb\u30ba\u30e0\u56f3\u89e3\uff5cAGEs\u751f\u6210\u306e3\u6bb5\u968e<\/p>\n<table style=\"width: 100%; border-collapse: collapse;\">\n<tr>\n<td style=\"vertical-align: top; padding: 8px 0; width: 50px;\">\n<svg width=\"36\" height=\"36\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"18\" cy=\"18\" r=\"16\" fill=\"#7b1fa2\"\/><text x=\"18\" y=\"24\" font-size=\"18\" fill=\"white\" text-anchor=\"middle\" font-weight=\"bold\">1<\/text><\/svg>\n<\/td>\n<td style=\"padding: 8px 0 8px 12px;\"><strong>\u521d\u671f\u53cd\u5fdc\uff08\u53ef\u9006\u7684\uff09<\/strong>\uff1a\u30b0\u30eb\u30b3\u30fc\u30b9\u306a\u3069\u306e\u9084\u5143\u7cd6\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30a2\u30df\u30ce\u57fa\uff08\u30ea\u30b8\u30f3\u6b8b\u57fa\u30fb\u30a2\u30eb\u30ae\u30cb\u30f3\u6b8b\u57fa\uff09\u3068\u7d50\u5408\u3057\u3001<strong>\u30b7\u30c3\u30d5\u5869\u57fa<\/strong>\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u6bb5\u968e\u3067\u306f\u307e\u3060\u5143\u306b\u623b\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top; padding: 8px 0; width: 50px;\">\n<svg width=\"36\" height=\"36\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"18\" cy=\"18\" r=\"16\" fill=\"#7b1fa2\"\/><text x=\"18\" y=\"24\" font-size=\"18\" fill=\"white\" text-anchor=\"middle\" font-weight=\"bold\">2<\/text><\/svg>\n<\/td>\n<td style=\"padding: 8px 0 8px 12px;\"><strong>\u4e2d\u671f\u53cd\u5fdc<\/strong>\uff1a\u30b7\u30c3\u30d5\u5869\u57fa\u304c<strong>\u30a2\u30de\u30c9\u30ea\u8ee2\u4f4d<\/strong>\u3092\u8d77\u3053\u3057\u3001\u300c\u30a2\u30de\u30c9\u30ea\u5316\u5408\u7269\u300d\uff08\u524d\u671f\u7cd6\u5316\u7523\u7269\uff09\u3092\u751f\u6210\u3057\u307e\u3059\u3002<strong>HbA1c<\/strong>\u306f\u3053\u306e\u6bb5\u968e\u306e\u4ee3\u8868\u7684\u306a\u6307\u6a19\u3067\u3001\u904e\u53bb1\u301c2\u304b\u6708\u306e\u5e73\u5747\u8840\u7cd6\u3092\u53cd\u6620\u3057\u307e\u3059\u3002<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: top; padding: 8px 0; width: 50px;\">\n<svg width=\"36\" height=\"36\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"18\" cy=\"18\" r=\"16\" fill=\"#c62828\"\/><text x=\"18\" y=\"24\" font-size=\"18\" fill=\"white\" text-anchor=\"middle\" font-weight=\"bold\">3<\/text><\/svg>\n<\/td>\n<td style=\"padding: 8px 0 8px 12px;\"><strong>\u5f8c\u671f\u53cd\u5fdc\uff08\u4e0d\u53ef\u9006\u7684\uff09<\/strong>\uff1a\u9178\u5316\u30fb\u8131\u6c34\u30fb\u7e2e\u5408\u53cd\u5fdc\u3092\u7d4c\u3066\u3001<strong>AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09<\/strong>\u304c\u6700\u7d42\u7684\u306b\u5f62\u6210\u3055\u308c\u307e\u3059\u3002\u4e00\u5ea6\u751f\u6210\u3055\u308c\u308b\u3068<strong>\u5206\u89e3\u30fb\u6392\u51fa\u304c\u6975\u3081\u3066\u56f0\u96e3<\/strong>\u3067\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u534a\u6e1b\u671f\u306e\u9577\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u84c4\u7a4d\u3059\u308b\u3068\u3001\u751f\u6daf\u306b\u308f\u305f\u3063\u3066\u7d44\u7e54\u306b\u7559\u307e\u308a\u7d9a\u3051\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/table>\n<\/div>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u4ee3\u8868\u7684\u306aAGEs\u69cb\u9020\u4f53<\/h3>\n<table style=\"width: 100%; background: #e8f5e9; border-left: 6px solid #2e7d32; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1b5e20; font-size: 1.1em;\">\u751f\u4f53\u5185\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u4e3b\u306aAGEs<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>N\u03b5-\u30ab\u30eb\u30dc\u30ad\u30b7\u30e1\u30c1\u30eb\u30ea\u30b8\u30f3\uff08CML\uff09<\/strong>\uff1a\u975e\u86cd\u5149\u6027\u30fb\u975e\u67b6\u6a4b\u6027\u3002\u8840\u4e2d\u3067\u6700\u3082\u591a\u304f\u691c\u51fa\u3055\u308c\u3001RAGE\uff08\u53d7\u5bb9\u4f53\uff09\u306e\u4e3b\u8981\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u708e\u75c7\u53cd\u5fdc\u3092\u60f9\u8d77\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u30da\u30f3\u30c8\u30b7\u30b8\u30f3<\/strong>\uff1a\u86cd\u5149\u6027\u30fb\u67b6\u6a4b\u6027\u3002\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08SAF\uff09\u6e2c\u5b9a\u306e\u4e3b\u8981\u30bf\u30fc\u30b2\u30c3\u30c8\u3002\u30b3\u30e9\u30fc\u30b2\u30f3\u67b6\u6a4b\u306b\u3088\u308b\u7d44\u7e54\u786c\u5316\u306b\u95a2\u4e0e\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u30e1\u30c1\u30eb\u30b0\u30ea\u30aa\u30ad\u30b5\u30fc\u30eb\u30ea\u30b8\u30f3\u30c0\u30a4\u30de\u30fc\uff08MOLD\uff09<\/strong>\uff1a\u975e\u86cd\u5149\u6027\u30fb\u67b6\u6a4b\u6027\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u306e\u75c5\u7684\u67b6\u6a4b\u3092\u5f62\u6210\u3002<\/p>\n<p style=\"margin: 0;\"><strong>\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u7531\u6765AGEs\uff08Glycer-AGEs \/ TAGE\uff09<\/strong>\uff1a\u6bd2\u6027\u304c\u7279\u306b\u5f37\u304f\u3001\u809d\u81d3\u75be\u60a3\uff08NASH\/MASLD\uff09\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u306e\u95a2\u9023\u304c\u5831\u544a\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-35.png\" alt=\"AGEs\u306e\u4f53\u3078\u306e\u5f71\u97ff\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<hr \/>\n<h2 id=\"sec2\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">2. AGEs\u306e2\u5927\u4f9b\u7d66\u7d4c\u8def \u2014 \u5185\u56e0\u6027\uff08\u9ad8\u8840\u7cd6\uff09\u3068\u5916\u56e0\u6027\uff08\u98df\u4e8b\u30fb\u55ab\u7159\uff09<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-39.png\" alt=\"\u30db\u30c3\u30c8\u30b1\u30fc\u30ad\u306e\u7cd6\u5316\u4f8b\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<table style=\"width: 100%; background: #e3f2fd; border-left: 6px solid #1976d2; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 12px 0; font-weight: bold; color: #1565c0; font-size: 1.1em;\">\u30dd\u30a4\u30f3\u30c8\uff5cAGEs\u84c4\u7a4d\u306e2\u5927\u7d4c\u8def<\/p>\n<p style=\"margin: 0 0 10px 0;\"><strong>\u2460 \u5185\u56e0\u6027AGEs\uff08\u5168\u4f53\u306e\u7d042\/3\uff09<\/strong>\uff1a\u9ad8\u8840\u7cd6\u72b6\u614b\u304c\u6301\u7d9a\u3059\u308b\u3068\u3001\u8840\u4e2d\u306e\u904e\u5270\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u4f53\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3066AGEs\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u30fb\u524d\u7cd6\u5c3f\u75c5\u30fb\u96a0\u308c\u7cd6\u5c3f\u75c5\uff08\u5883\u754c\u578b\uff09\u306e\u65b9\u3067\u306f\u3053\u306e\u7d4c\u8def\u304c\u8457\u3057\u304f\u4ea2\u9032\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin: 0;\"><strong>\u2461 \u5916\u56e0\u6027AGEs\uff08\u5168\u4f53\u306e\u7d041\/3\uff09<\/strong>\uff1a\u98df\u54c1\u3092\u9ad8\u6e29\u3067\u52a0\u71b1\u8abf\u7406\uff08\u63da\u3052\u308b\u30fb\u713c\u304f\u30fb\u7092\u3081\u308b\uff09\u3057\u305f\u969b\u306b\u751f\u6210\u3055\u308c\u308bAGEs\u3092\u98df\u4e8b\u304b\u3089\u6442\u53d6\u3059\u308b\u7d4c\u8def\u3067\u3059\u3002\u6442\u53d6\u3057\u305f\u5916\u56e0\u6027AGEs\u306e<strong>\u7d047\u5272\u304c\u4f53\u5185\u306b\u6b8b\u7559<\/strong>\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u55ab\u7159\u3082AGEs\u306e\u91cd\u8981\u306a\u5916\u56e0\u6027\u4f9b\u7d66\u6e90\u3067\u3001\u30bf\u30d0\u30b3\u306e\u8449\u3092\u4e7e\u71e5\u3055\u305b\u308b\u904e\u7a0b\u3067\u751f\u3058\u305fAGEs\u304c\u80ba\u304b\u3089\u5438\u53ce\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u5206\u304b\u308a\u3084\u3059\u3044\u4f8b\u3068\u3057\u3066\u3001\u30db\u30c3\u30c8\u30b1\u30fc\u30ad\u304c\u3042\u308a\u307e\u3059\u3002\u5c0f\u9ea6\u7c89\uff08\u7cd6\u8cea\uff09\u3092\u7df4\u3063\u3066\u3001\u725b\u4e73\u3084\u5375\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u52a0\u3048\u3066\u713c\u3044\u305f\u3068\u304d\u306e\u3001\u304d\u3064\u306d\u8272\u306e\u7126\u3052\u76ee\u3053\u305d\u304cAGEs\u3067\u3059\u3002\u30b9\u30c6\u30fc\u30ad\u3001\u5510\u63da\u3052\u3001\u30c8\u30fc\u30b9\u30c8\u3001\u30d5\u30e9\u30a4\u30c9\u30dd\u30c6\u30c8\u3001\u63da\u3052\u305b\u3093\u3079\u3044\u306a\u3069\u3001\u79c1\u305f\u3061\u304c\u65e5\u5e38\u7684\u306b\u53e3\u306b\u3057\u3066\u3044\u308b\u8910\u8272\u306e\u98df\u54c1\u306b\u3082AGEs\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; border-collapse: collapse; margin: 20px 0; background: white;\">\n<thead>\n<tr style=\"background: #004d40; color: white;\">\n<th style=\"padding: 12px; text-align: left; border: 1px solid #004d40;\">\u8abf\u7406\u6cd5<\/th>\n<th style=\"padding: 12px; text-align: left; border: 1px solid #004d40;\">\u6e29\u5ea6\u306e\u76ee\u5b89<\/th>\n<th style=\"padding: 12px; text-align: left; border: 1px solid #004d40;\">AGEs\u751f\u6210\u91cf<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9;\">\u8339\u3067\u308b\u30fb\u84b8\u3059\u30fb\u716e\u308b<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9;\">\u7d04100\u2103<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9; color:#1976d2; font-weight:bold;\">\u5c11\u306a\u3044\uff08\u63a8\u5968\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ccc;\">\u96fb\u5b50\u30ec\u30f3\u30b8\u52a0\u71b1<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc;\">100\u301c120\u2103<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; color:#1976d2; font-weight:bold;\">\u5c11\u306a\u3081<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9;\">\u7092\u3081\u308b<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9;\">\u7d04140\u301c160\u2103<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9; color:#ef6c00; font-weight:bold;\">\u4e2d\u7a0b\u5ea6<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ccc;\">\u63da\u3052\u308b<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc;\">\u7d04170\u301c200\u2103<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; color:#c62828; font-weight:bold;\">\u591a\u3044<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9;\">\u76f4\u706b\u713c\u304d\u30fb\u30aa\u30fc\u30d6\u30f3\u713c\u304d<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9;\">200\u2103\u4ee5\u4e0a<\/td>\n<td style=\"padding: 12px; border: 1px solid #ccc; background: #f9f9f9; color:#c62828; font-weight:bold;\">\u6700\u3082\u591a\u3044<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u540c\u3058\u9d8f\u3080\u306d\u8089\u3067\u3082\u3001\u713c\u304d\u9ce5\uff08\u76f4\u706b\u713c\u304d\uff09\u306f\u6c34\u708a\u304d\u306e<strong>\u7d045\u301c10\u500d<\/strong>\u306eAGEs\u3092\u542b\u3080\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff08Uribarri J, et al. <em>J Am Diet Assoc<\/em>. 2010\uff09\u3002<\/p>\n<hr \/>\n<h2 id=\"sec3\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">3. AGEs\u306f\u306a\u305c\u5371\u967a\u304b\uff1f\u2014 RAGE\u53d7\u5bb9\u4f53\u3068\u5168\u8eab\u3078\u306e\u5f71\u97ff<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-32.png\" alt=\"AGEs\u84c4\u7a4d\u306e\u4ed5\u7d44\u307f\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<p>AGEs\u304c\u4f53\u306b\u5bb3\u3092\u53ca\u307c\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u5927\u304d\u304f<strong>2\u3064\u306e\u7d4c\u8def<\/strong>\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u7d4c\u8def1\uff1a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u67b6\u6a4b\u5f62\u6210\uff08\u69cb\u9020\u7684\u969c\u5bb3\uff09<\/h3>\n<p>AGEs\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306a\u3069\u306e\u9577\u5bff\u547d\u30bf\u30f3\u30d1\u30af\u8cea\u306b<strong>\u75c5\u7684\u306a\u67b6\u6a4b\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30af\uff09<\/strong>\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u7d44\u7e54\u304c\u786c\u304f\u8106\u304f\u306a\u308a\u3001\u8840\u7ba1\u58c1\u306e\u5f3e\u529b\u4f4e\u4e0b\uff08\u52d5\u8108\u786c\u5316\uff09\u3001\u76ae\u819a\u306e\u3057\u308f\u30fb\u305f\u308b\u307f\u3001\u9aa8\u5f37\u5ea6\u306e\u4f4e\u4e0b\uff08\u9aa8\u7c97\u9b06\u75c7\uff09\u3001\u95a2\u7bc0\u306e\u3053\u308f\u3070\u308a\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u7d4c\u8def2\uff1aRAGE\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u708e\u75c7\u30fb\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff08\u6a5f\u80fd\u7684\u969c\u5bb3\uff09<\/h3>\n<p>AGEs\u306f\u7d30\u80de\u8868\u9762\u306e<strong>RAGE\uff08Receptor for AGEs\uff1aAGEs\u53d7\u5bb9\u4f53\uff09<\/strong>\u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u6700\u65b0\u306e\u7dcf\u8aac\uff08<em>PMC, 2025<\/em>\uff09\u306b\u3088\u308c\u3070\u3001AGE-RAGE\u7cfb\u306f<strong>NF-\u03baB\u7d4c\u8def<\/strong>\u3092\u4e2d\u5fc3\u3068\u3059\u308b\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u3001<strong>NADPH \u30aa\u30ad\u30b7\u30c0\u30fc\u30bc<\/strong>\u3092\u4ecb\u3057\u305f\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u7523\u751f\u3001<strong>TGF-\u03b2<\/strong>\u3092\u4ecb\u3057\u305f\u7dda\u7dad\u5316\u30b7\u30b0\u30ca\u30eb\u3092\u540c\u6642\u306b\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u7b4b\u7dda\u7dad\u5316\u30fb\u8840\u7ba1\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u30fb\u52d5\u8108\u786c\u5316\u3092\u52a0\u901f\u3055\u305b\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #fff3e0; border-left: 6px solid #f57c00; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #e65100; font-size: 1.1em;\">AGE-RAGE\u7cfb\u304c\u5f15\u304d\u8d77\u3053\u3059\u4e3b\u306a\u751f\u4f53\u53cd\u5fdc<\/p>\n<p style=\"margin: 0 0 6px 0;\">\u30fbNF-\u03baB\u6d3b\u6027\u5316 \u2192 \u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TNF-\u03b1\u3001IL-6\uff09\u7523\u751f\u4ea2\u9032<\/p>\n<p style=\"margin: 0 0 6px 0;\">\u30fbNADPH \u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\u6d3b\u6027\u5316 \u2192 \u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u7523\u751f\u5897\u52a0<\/p>\n<p style=\"margin: 0 0 6px 0;\">\u30fbNO\uff08\u4e00\u9178\u5316\u7a92\u7d20\uff09\u7523\u751f\u4f4e\u4e0b \u2192 \u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3<\/p>\n<p style=\"margin: 0 0 6px 0;\">\u30fbVEGF\u767a\u73fe\u4ea2\u9032 \u2192 \u8840\u7ba1\u900f\u904e\u6027\u4ea2\u9032\u30fb\u75c5\u7684\u8840\u7ba1\u65b0\u751f<\/p>\n<p style=\"margin: 0 0 6px 0;\">\u30fb\u63a5\u7740\u5206\u5b50\uff08VCAM-1\u3001ICAM-1\uff09\u767a\u73fe\u4e0a\u6607 \u2192 \u52d5\u8108\u786c\u5316\u4fc3\u9032<\/p>\n<p style=\"margin: 0;\">\u30fbTGF-\u03b2\u6d3b\u6027\u5316 \u2192 \u5fc3\u7b4b\u7dda\u7dad\u5316\u30fb\u814e\u7dda\u7dad\u5316<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u3064\u307e\u308aAGEs\u306f\u3001\u7cd6\u5c3f\u75c5\u30fb\u5fc3\u8840\u7ba1\u75c5\u30fb\u814e\u81d3\u75c5\u30fb\u9aa8\u75be\u60a3\u30fb\u8a8d\u77e5\u75c7\u306a\u3069\u3001\u4e00\u898b\u30d0\u30e9\u30d0\u30e9\u306b\u898b\u3048\u308b\u75be\u60a3\u3092\u300c<strong>\u6162\u6027\u708e\u75c7\u3068\u7d44\u7e54\u786c\u5316<\/strong>\u300d\u3068\u3044\u3046\u5171\u901a\u57fa\u76e4\u3067\u3064\u306a\u3052\u308b\u300c\u75c5\u6c17\u306e\u5171\u901a\u9805\u300d\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<hr \/>\n<h2 id=\"sec4\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">4. AGEs\u3068\u5fc3\u8840\u7ba1\u75be\u60a3 \u2014 2025\u5e74\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-38.png\" alt=\"AGEs\u3068\u95a2\u9023\u75be\u60a3\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<table style=\"width: 100%; background: #fce4ec; border-left: 6px solid #c2185b; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #880e4f; font-size: 1.1em;\">\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\uff5c2025\u5e74\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff08Springer Nature\u30fbPMC\u53ce\u8f09\uff09<\/p>\n<p style=\"margin: 0 0 8px 0;\">2025\u5e743\u6708\u307e\u3067\u306e\u524d\u5411\u304d\u7814\u7a76\u3092\u7d71\u5408\u3057\u305f\u5927\u898f\u6a21\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3067\u306f\u3001<strong>\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08SAF\uff09\u9ad8\u5024<\/strong>\u304c\u4ee5\u4e0b\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff08<em>Eur J Med Res<\/em>, 2026; <em>Clin Res Cardiol<\/em>, 2025\uff09\u3002<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u30fb<strong>\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u60a3\u8005\u306e\u5168\u6b7b\u4ea1<\/strong>\uff1aHR 1.65\uff0895%CI 1.35-2.01\uff09<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u30fb<strong>\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5168\u6b7b\u4ea1<\/strong>\uff1aHR 1.61\uff0895%CI 1.14-2.29\uff09<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u30fb<strong>\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/strong>\uff1aHR 1.67\uff0895%CI 1.19-2.35\uff09<\/p>\n<p style=\"margin: 0;\">\u30fb<strong>\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/strong>\uff1aHR 1.63\uff0895%CI 1.27-2.09\uff09<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001<strong>\u672b\u671f\u814e\u4e0d\u5168\uff08ESRD\uff09\u60a3\u8005\u3067\u306fAGEs\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u95a2\u9023\u304c\u7279\u306b\u5f37\u304f<\/strong>\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308bAGEs\u6392\u6cc4\u80fd\u306e\u4f4e\u4e0b\u304c\u72ec\u7acb\u3057\u305f\u4e88\u5f8c\u56e0\u5b50\u3068\u306a\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u300c\u8840\u7cd6\u304c\u826f\u597d\u3067\u3082AGEs\u304c\u9ad8\u3044\u300d\u3068\u3044\u3046\u30b1\u30fc\u30b9\u304c\u5b58\u5728\u3057\u3001HbA1c\u3060\u3051\u3067\u306f\u6349\u3048\u304d\u308c\u306a\u3044\u30ea\u30b9\u30af\u3092SAF\u304c\u88dc\u5b8c\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001Lutgers HL\u3089\u306e<em>Diabetologia<\/em>\u7814\u7a76\uff082018\uff09\u3067\u306f\u3001<strong>\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3044\u3066\u3082SAF\u9ad8\u5024\u304c\u5c06\u6765\u306e2\u578b\u7cd6\u5c3f\u75c5\u767a\u75c7\u30fb\u5fc3\u8840\u7ba1\u75be\u60a3\u767a\u75c7\u30fb\u5168\u6b7b\u4ea1\u3092\u72ec\u7acb\u3057\u3066\u4e88\u6e2c\u3059\u308b<\/strong>\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061AGEs\u306e\u84c4\u7a4d\u8a55\u4fa1\u306f\u3001\u7cd6\u5c3f\u75c5\u3084CKD\u3092\u3059\u3067\u306b\u767a\u75c7\u3057\u305f\u65b9\u3060\u3051\u3067\u306a\u304f\u3001<strong>\u5065\u5e38\u8005\u306e\u4e88\u9632\u533b\u5b66\u7684\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong>\u3068\u3057\u3066\u3082\u6709\u7528\u3067\u3059\u3002<\/p>\n<p>AGEs\u306b\u3088\u308b\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\u3060\u3051\u3067\u306a\u304f<strong>\u52c3\u8d77\u4e0d\u5168\uff08ED\uff09<\/strong>\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001ED\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u6570\u5e74\u5148\u884c\u3059\u308b\u521d\u671f\u30b5\u30a4\u30f3\u3068\u3057\u3066\u8fd1\u5e74\u518d\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #e3f2fd; border-left: 6px solid #1976d2; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1565c0; font-size: 1.1em;\">\u95a2\u9023\u8a18\u4e8b\uff5c\u7cd6\u5c3f\u75c5\u6cbb\u7642\u3068\u52d5\u8108\u786c\u5316\u5bfe\u7b56<\/p>\n<p style=\"margin: 0 0 8px 0; line-height:1.7;\">\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\u3067\u306f\u3001\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u963b\u5bb3\u85ac\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u3044\u3063\u305f\u85ac\u5264\u304c\u3001\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3092\u8d85\u3048\u305f\u591a\u9762\u7684\u52b9\u679c\uff08\u5fc3\u8840\u7ba1\u4fdd\u8b77\u30fb\u814e\u4fdd\u8b77\u30fb\u6297AGE\u4f5c\u7528\uff09\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u8a73\u3057\u304f\u306f <a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/diabetes-treatment-metformin-sglt2-cgm-geroscience-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#1565c0;\"><strong>\u300c\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\uff5c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u30fbCGM\u500b\u5225\u5316\uff0b\u6297\u8001\u5316\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p style=\"margin: 0; line-height:1.7;\">\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u30fb\u52d5\u8108\u786c\u5316\u3078\u306e\u9032\u884c\u306b\u306f\u3001\u5185\u81d3\u8102\u80aa\u7531\u6765\u306e\u6162\u6027\u708e\u75c7\u3068\u9ad8\u8840\u7cd6\u304cAGE\u84c4\u7a4d\u3092\u52a0\u901f\u3055\u305b\u308b\u60aa\u5faa\u74b0\u304c\u95a2\u4e0e\u3057\u307e\u3059\u3002<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/metabolic-syndrome-diabetes-progression-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#1565c0;\"><strong>\u300c\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\uff5c2024\u5e74\u65b0\u57fa\u6e96\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3092\u5fb9\u5e95\u89e3\u8aac\u300d<\/strong><\/a>\u3082\u3042\u308f\u305b\u3066\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<hr \/>\n<h2 id=\"sec5\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">5. AGEs\u3068\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u30fb\u6162\u6027\u814e\u81d3\u75c5<\/h2>\n<p>\u7cd6\u5c3f\u75c5\u306f\u300c\u8eab\u4f53\u3092\u8001\u5316\u3055\u305b\u308b\u75c5\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u9ad8\u8840\u7cd6\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u8102\u8cea\u7570\u5e38\u306a\u3069\u306e\u75c5\u7684\u72b6\u614b\u3067\u306fAGEs\u751f\u6210\u91cf\u304c\u8457\u3057\u304f\u5897\u52a0\u3057\u307e\u3059\u3002AGEs\u306e\u84c4\u7a4d\u306f\u7cd6\u5c3f\u75c5\u306e<strong>\u4e09\u5927\u5408\u4f75\u75c7<\/strong>\uff08\u7db2\u819c\u75c7\u30fb\u814e\u75c7\u30fb\u795e\u7d4c\u969c\u5bb3\uff09\u306e\u3059\u3079\u3066\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u5927\u8840\u7ba1\u969c\u5bb3\uff08\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\uff09\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3082\u9ad8\u3081\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #e3f2fd; border-left: 6px solid #1976d2; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1565c0; font-size: 1.1em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff5c\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u3068AGEs<\/p>\n<p style=\"margin: 0;\">\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u60a3\u8005\u3067\u306f\u3001\u814e\u81d3\u3067\u306eAGEs\u6392\u6cc4\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u4f53\u5185\u84c4\u7a4d\u304c\u52a0\u901f\u3057\u307e\u3059\u3002<strong>AGEs\u3068\u9aa8\u4ee3\u8b1d\u7570\u5e38\uff08\u814e\u6027\u9aa8\u7570\u6804\u990a\u75c7\uff09<\/strong>\u3001<strong>\u5c3f\u7d30\u7ba1\u969c\u5bb3<\/strong>\u306e\u95a2\u9023\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u307b\u304b\u3001\u8840\u6db2\u900f\u6790\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u306e\u7d4c\u6642\u7684\u4e0a\u6607\u304c<strong>\u6b7b\u4ea1\u7387\u306e\u72ec\u7acb\u4e88\u6e2c\u56e0\u5b50<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Meerwaldt R, et al. <em>Diabetologia<\/em>, 2004; Wang AYM, et al. systematic review, 2020\uff09\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528 \u2014 \u6cbb\u7642\u85ac\u306e\u9032\u5316<\/h3>\n<p>\u8fd1\u5e74\u3001<strong>\u7cd6\u5c3f\u75c5\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32024\uff08\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a\uff09<\/strong>\u3067\u3082\u5f37\u8abf\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001SGLT2\u963b\u5bb3\u85ac\u30fbGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u30fb\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u306b\u306f\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3092\u8d85\u3048\u305f\u591a\u9762\u7684\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001<strong>AGE-RAGE\u7cfb\u306e\u6291\u5236\u3092\u4ecb\u3057\u305f\u81d3\u5668\u4fdd\u8b77\u4f5c\u7528<\/strong>\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3092\u4f34\u3046\u7cd6\u5c3f\u75c5\u6027\u814e\u81d3\u75c5\u306b\u5bfe\u3057\u3066\u306f\u3001SGLT2\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u304c<strong>\u63a8\u5968\u30b0\u30ec\u30fc\u30c9A<\/strong>\u3067\u63a8\u5968\u3055\u308c\u3066\u304a\u308a\u3001\u814e\u4e88\u5f8c\u6539\u5584\u30fb\u5fc3\u8840\u7ba1\u4e88\u5f8c\u6539\u5584\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u78ba\u7acb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #e3f2fd; border-left: 6px solid #1976d2; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1565c0; font-size: 1.1em;\">\u95a2\u9023\u8a18\u4e8b\uff5c\u5bb6\u65cf\u6b74\u306e\u3042\u308b\u65b9\u306e\u7cd6\u5c3f\u75c5\u30fb\u8102\u8cea\u7570\u5e38\u75c7\u5bfe\u7b56<\/p>\n<p style=\"margin: 0; line-height:1.7;\">\u7cd6\u5c3f\u75c5\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u65b9\u306f\u3001\u767a\u75c7\u524d\u304b\u3089AGE\u84c4\u7a4d\u304c\u59cb\u307e\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u65e9\u671f\u5bfe\u7b56\u30fb\u62e1\u5927\u8102\u8cea\u691c\u67fb\u30fbFH\uff08\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff09\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306b\u3064\u3044\u3066\u306f <a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/diabetes-family-history-fh-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#1565c0;\"><strong>\u300c\u89aa\u304c\u7cd6\u5c3f\u75c5\u3060\u3068\u81ea\u5206\u3082\uff1f\uff5c\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u4eba\u306e\u65e9\u671f\u5bfe\u7b56\u30fb\u62e1\u5927\u8102\u8cea\u691c\u67fb\u30fbFH\u3092\u89e3\u8aac\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<hr \/>\n<h2 id=\"sec6\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">6. AGEs\u3068\u30d5\u30ec\u30a4\u30eb\u30fb\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u9aa8\u7c97\u9b06\u75c7<\/h2>\n<table style=\"width: 100%; background: #e8f5e9; border-left: 6px solid #2e7d32; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1b5e20; font-size: 1.1em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff5cRotterdam Study\uff082022\u5e74\uff09\u2014 \u30d5\u30ec\u30a4\u30eb\u3068AGEs<\/p>\n<p style=\"margin: 0;\">Waqas K\u3089\u306f\u3001Rotterdam Study\u306e<strong>2,521\u540d<\/strong>\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6a2a\u65ad\u7814\u7a76\u3067\u3001SAF\u3067\u8a55\u4fa1\u3057\u305fAGEs\u84c4\u7a4d\u91cf\u304c\u30d5\u30ec\u30a4\u30eb\uff08Fried\u57fa\u6e96\u30fbRockwood\u30d5\u30ec\u30a4\u30eb\u30a4\u30f3\u30c7\u30c3\u30af\u30b9\u53cc\u65b9\uff09\u3068<strong>\u6709\u610f\u306b\u95a2\u9023<\/strong>\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08<em>J Gerontol A Biol Sci Med Sci<\/em>, 2022\uff09\u3002\u30d5\u30ec\u30a4\u30eb\u306e\u7a0b\u5ea6\u304c\u91cd\u3044\u307b\u3069SAF\u5024\u306f\u9ad8\u304f\u3001\u3053\u306e\u95a2\u9023\u306f<strong>\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a<\/strong>\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u540c\u3058\u304fRotterdam Study\u306e2,744\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u7814\u7a76\uff08<em>J Clin Endocrinol Metab<\/em>, 2022\uff09\u3067\u306f\u3001SAF\u5024\u304c\u6700\u3082\u9ad8\u3044\u7fa4\uff08\u7b2c4\u56db\u5206\u4f4d\uff09\u306f\u6700\u3082\u4f4e\u3044\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001<strong>\u63e1\u529b\u4f4e\u4e0b<\/strong>\u3084<strong>\u9aa8\u683c\u7b4b\u91cf\u4f4e\u4e0b<\/strong>\u306e\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u9ad8\u304f\u3001\u78ba\u5b9a\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u306e\u6709\u75c5\u7387\u3082\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002AGEs\u304c\u7b4b\u8089\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u67b6\u6a4b\u3092\u5f62\u6210\u3057\u3001\u7b4b\u8089\u306e\u8cea\u3068\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>2025\u5e74\u306b\u65e5\u672c\u3067\u767a\u520a\u3055\u308c\u305f<strong>\u300e\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u30d5\u30ec\u30a4\u30eb\u306b\u95a2\u3059\u308b\u6804\u990a\u7ba1\u7406\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32025\u300f<\/strong>\uff08\u5357\u6c5f\u5802\uff09\u3067\u3082\u3001\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u5bfe\u7b56\u304c\u6804\u990a\u7ba1\u7406\u306e\u91cd\u8981\u306a\u67f1\u3068\u3057\u3066\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u9aa8\u7c97\u9b06\u75c7\u30fb\u9aa8\u6298\u30ea\u30b9\u30af \u2014 \u300c\u9aa8\u8cea\u300d\u306e\u554f\u984c<\/h3>\n<p>\u9aa8\u306e\u7d0450%\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002AGEs\u304c\u3053\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u67b6\u6a4b\u3092\u5f62\u6210\u3059\u308b\u3068\u3001\u9aa8\u306e\u3057\u306a\u3084\u304b\u3055\u304c\u5931\u308f\u308c\u3001<strong>\u9aa8\u8cea\u304c\u52a3\u5316<\/strong>\u3057\u307e\u3059\u3002\u9aa8\u5bc6\u5ea6\uff08BMD\uff09\u304c\u6b63\u5e38\u3067\u3042\u3063\u3066\u3082\u3001AGEs\u84c4\u7a4d\u306b\u3088\u308a\u9aa8\u6298\u30ea\u30b9\u30af\u304c\u4e0a\u6607\u3059\u308b\u30b1\u30fc\u30b9\u304c\u3042\u308a\u3001\u3053\u308c\u306f\u5f93\u6765\u306e\u9aa8\u5bc6\u5ea6\u691c\u67fb\u3060\u3051\u3067\u306f\u6349\u3048\u304d\u308c\u306a\u3044\u300c<strong>\u9aa8\u8cea\u306e\u554f\u984c<\/strong>\u300d\u3067\u3059\u3002Rotterdam Study\u3067\u306f\u3001SAF\u9ad8\u5024\u304c<strong>\u690e\u4f53\u9aa8\u6298\u304a\u3088\u3073\u4e3b\u8981\u9aa8\u7c97\u9b06\u75c7\u6027\u9aa8\u6298\u306e\u6709\u75c5<\/strong>\u3068\u6709\u610f\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08Waqas K, et al. <em>J Bone Miner Res<\/em>, 2020\uff09\u3002<\/p>\n<table style=\"width: 100%; background: #e3f2fd; border-left: 6px solid #1976d2; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1565c0; font-size: 1.1em;\">\u30b0\u30eb\u30fc\u30d7\u5185\u9023\u643a\uff5c\u9ad8\u9f62\u8005\u7cd6\u5c3f\u75c5\u30fb\u30d5\u30ec\u30a4\u30eb\u5916\u6765<\/p>\n<p style=\"margin: 0; line-height:1.7;\">\u4e94\u826f\u4f1a\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u7530\u5712\u8abf\u5e03\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\u306b\u52a0\u3048\u3001<strong>\u6a2a\u6d5c\u5e02\u90fd\u7b51\u533a\u306e\u4e94\u826f\u30d5\u30a1\u30df\u30ea\u30fc\u30af\u30ea\u30cb\u30c3\u30af\u30bb\u30f3\u30bf\u30fc\u5357<\/strong>\u3067\u3082\u9ad8\u9f62\u8005\u7cd6\u5c3f\u75c5\u30fb\u30d5\u30ec\u30a4\u30eb\u30fb\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u8a8d\u77e5\u75c7\u5916\u6765\u3092\u4f75\u8a2d\u3057\u3066\u304a\u308a\u3001\u3054\u5bb6\u65cf\u306e\u30e9\u30a4\u30d5\u30b9\u30c6\u30fc\u30b8\u306b\u5408\u308f\u305b\u305f\u7d99\u7d9a\u8a3a\u7642\u4f53\u5236\u3092\u6574\u3048\u3066\u304a\u308a\u307e\u3059\u3002<a href=\"https:\/\/goryo-family.clinic\/blog\" target=\"_blank\" rel=\"noopener\" style=\"color:#1565c0;\"><strong>\u30bb\u30f3\u30bf\u30fc\u5357\u306e\u30d6\u30ed\u30b0<\/strong><\/a>\u3082\u3042\u308f\u305b\u3066\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<hr \/>\n<h2 id=\"sec7\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">7. AGEs\u3068\u8a8d\u77e5\u75c7\u30fb\u3046\u3064\u75c5 \u2014 \u8133\u3068\u3053\u3053\u308d\u3078\u306e\u5f71\u97ff<\/h2>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u8a8d\u77e5\u75c7\uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff09\u3068\u306e\u95a2\u9023<\/h3>\n<p>\u8133\u5185\u306bAGEs\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001<strong>\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u304c\u4fc3\u9032<\/strong>\u3055\u308c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002AGEs\u306b\u3088\u308b\u6162\u6027\u795e\u7d4c\u708e\u75c7\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u30fb\u8131\u843d\u3092\u52a0\u901f\u3055\u305b\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u56e0\u5b50\uff08\u3044\u308f\u3086\u308b\u300c3\u578b\u7cd6\u5c3f\u75c5\u300d\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u3068\u3055\u308c\u308b\u80cc\u666f\u306b\u306f\u3001\u3053\u306e\u7cd6\u5316\u7d4c\u8def\u304c\u6df1\u304f\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u65e5\u672c\u5185\u79d1\u5b66\u4f1a\u306e\u7dcf\u8aac\uff082018\uff09\u3067\u3082\u3001\u8a8d\u77e5\u75c7\u3068\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u30d5\u30ec\u30a4\u30eb\u306f\u300c\u540c\u3058\u6162\u6027\u708e\u75c7\u30fb\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30fb\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u57fa\u76e4\u3068\u3059\u308b\u75c5\u614b\u7fa4\u300d\u3068\u3057\u3066\u6574\u7406\u3055\u308c\u3066\u304a\u308a\u3001AGE\u6e2c\u5b9a\u304c\u65e9\u671f\u4ecb\u5165\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u3046\u3064\u75c5\uff08\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\uff09\u3068\u306e\u95a2\u9023<\/h3>\n<table style=\"width: 100%; background: #e8f5e9; border-left: 6px solid #2e7d32; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1b5e20; font-size: 1.1em;\">\u30a8\u30d3\u30c7\u30f3\u30b9\uff5cHelsinki Birth Cohort Study\uff082021\u5e74\uff09<\/p>\n<p style=\"margin: 0 0 8px 0;\">Eriksson MD\u3089\u306f\u3001Helsinki Birth Cohort Study\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u306b\u3001SAF\u3067\u6e2c\u5b9a\u3057\u305fAGEs\u5024\u3068\u3046\u3064\u75c7\u72b6\uff08Beck Depression Inventory\uff09\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\uff08<em>J Psychosom Res<\/em>, 2021\uff09\u3002<strong>\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\u3046\u3064\u75c7\u72b6\u3092\u6709\u3059\u308b\u7fa4\u306eAGEs\u5024\uff082.61 AU\uff09<\/strong>\u306f\u3001\u975e\u30e1\u30e9\u30f3\u30b3\u30ea\u30fc\u578b\uff082.45 AU\uff09\u3001\u3046\u3064\u75c7\u72b6\u306a\u3057\u7fa4\uff082.38 AU\uff09\u3068\u6bd4\u8f03\u3057\u3066<strong>\u6709\u610f\u306b\u9ad8\u5024<\/strong>\u3067\u3057\u305f\uff08p = 0.013\uff09\u3002<\/p>\n<p style=\"margin: 0;\">\u4e2d\u56fd\u306eREACTION\u7814\u7a76\uff084,420\u540d\u5bfe\u8c61\u30012023\u5e74\uff09\u3067\u3082\u3001SAF-AGEs\u306e\u56db\u5206\u4f4d\u5024\u304c\u4e0a\u6607\u3059\u308b\u306b\u3064\u308c\u3001\u3046\u3064\u75c7\u72b6\u306e\u30ea\u30b9\u30af\u304c\u30aa\u30c3\u30ba\u6bd4<strong>1.24 \u2192 1.39 \u2192 1.57<\/strong>\u3068\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u5f53\u9662\u306f<strong>\u5fc3\u7642\u5185\u79d1<\/strong>\u3082\u4f75\u8a2d\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u3001\u4e0d\u7720\u3001\u6162\u6027\u7684\u306a\u75b2\u52b4\u611f\u306a\u3069\u3001\u3053\u3053\u308d\u306e\u4e0d\u8abf\u3068\u8eab\u4f53\u306e\u8001\u5316\uff08\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\uff09\u3092\u4e00\u4f53\u3067\u8a55\u4fa1\u3059\u308b\u300c<strong>\u8eab\u4f53\u30fb\u7cbe\u795e\u7d71\u5408\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong>\u300d\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<hr \/>\n<h2 id=\"sec8\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">8. AGEs\u3068\u76ae\u819a\u8001\u5316\u30fb\u5c0f\u5150\u671f\u304b\u3089\u306e\u84c4\u7a4d\u30ea\u30b9\u30af<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-36.png\" alt=\"AGEs\u3068\u76ae\u819a\u8001\u5316\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<p>\u76ae\u819a\u3092\u69cb\u6210\u3059\u308b\u4e3b\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u306bAGEs\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3001<strong>\u5f3e\u529b\u6027\u306e\u55aa\u5931<\/strong>\uff08\u3057\u308f\u30fb\u305f\u308b\u307f\uff09\u3001<strong>\u9ec4\u8910\u8272\u306e\u304f\u3059\u307f<\/strong>\uff08\u7cd6\u5316\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\uff09\u304c\u9032\u884c\u3057\u307e\u3059\u3002AGEs\u306f\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u3092\u523a\u6fc0\u3057\u3066\u30b7\u30df\u306e\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>2025\u5e74\u306b\u767a\u8868\u3055\u308c\u305fAntioxidants\u8a8c\u306e\u30ec\u30d3\u30e5\u30fc\uff08<em>Antioxidants<\/em>, 2025; 14(4):498\uff09\u3067\u306f\u3001\u6297\u7cd6\u5316\u30fb\u6297\u9178\u5316\u6d3b\u6027\u3092\u6301\u3064\u5316\u5408\u7269\uff08\u5916\u7528\u30fb\u7d4c\u53e3\uff09\u304c\u3001\u52a0\u9f62\u30fb\u7cd6\u5c3f\u75c5\u30fb\u9ad8\u7cd6\u8cea\u98df\u30fb\u7d2b\u5916\u7dda\u66dd\u9732\u30fb\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u76ae\u819aAGEs\u84c4\u7a4d\u3092\u6709\u610f\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u591a\u6570\u306e\u52d5\u7269\u30fb\u81e8\u5e8a\u7814\u7a76\u3067\u793a\u3055\u308c\u305f\u3068\u7dcf\u62ec\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5c0f\u5150\u671f\u304b\u3089\u306e\u84c4\u7a4d\u3082 \u2014 \u5f53\u9662\u304c\u5c0f\u5150\u79d1\u4f75\u8a2d\u3067\u3042\u308b\u7406\u7531<\/h3>\n<p>2025\u5e74\u306e\u7814\u7a76\uff08<em>Int J Mol Sci<\/em>, 2025; 26(20):9966\uff09\u3067\u306f\u3001<strong>\u80a5\u6e80\u5150\u306b\u304a\u3044\u3066\u3082AGEs\u30fb\u30e1\u30c1\u30eb\u30b0\u30ea\u30aa\u30ad\u30b5\u30fc\u30eb\uff08MG\uff09\u30fbE-\u30bb\u30ec\u30af\u30c1\u30f3\u30fbhs-CRP\u304c\u6709\u610f\u306b\u4e0a\u6607<\/strong>\u3057\u3001\u52d5\u8108\u786c\u5316\u306e\u65e9\u671f\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u904b\u52d5\u91cf\u304c\u5c11\u306a\u3044\u5c0f\u5150\u3067\u306fAGEs\u84c4\u7a4d\u304c\u9032\u884c\u3057\u3084\u3059\u304f\u3001<strong>\u82e5\u5e74\u671f\u304b\u3089\u306e\u751f\u6d3b\u7fd2\u6163\u306e\u91cd\u8981\u6027<\/strong>\u304c\u6539\u3081\u3066\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5f53\u9662\u306f<strong>\u5185\u79d1\u30fb\u5c0f\u5150\u79d1\u3092\u4f75\u8a2d<\/strong>\u3057\u3066\u3044\u308b\u5f37\u307f\u3092\u6d3b\u304b\u3057\u3001<strong>\u300c\u89aa\u5b50\u3067\u751f\u6d3b\u7fd2\u6163\u3092\u898b\u76f4\u3059\u300d<\/strong>\u5916\u6765\u3092\u3054\u63d0\u6848\u3057\u3066\u3044\u307e\u3059\u3002\u304a\u7236\u69d8\u30fb\u304a\u6bcd\u69d8\u306e\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u3068\u3001\u304a\u5b50\u69d8\u306e\u98df\u4e8b\u30fb\u904b\u52d5\u6307\u5c0e\u3092\u540c\u6642\u306b\u884c\u3046\u3053\u3068\u3067\u3001\u5bb6\u65cf\u3050\u308b\u307f\u3067AGEs\u5bfe\u7b56\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #fff3e0; border-left: 6px solid #f57c00; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 8px 0; font-weight: bold; color: #e65100; font-size: 1.1em;\">AGEs\u306b\u95a2\u3059\u308b\u591a\u9818\u57df\u306e\u6700\u65b0\u7814\u7a76\u77e5\u898b<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u8033\u305f\u3076\u306e\u3057\u308f\uff08Frank\u5fb4\u5019\uff09\u3068\u306e\u95a2\u9023<\/strong>\uff1a\u8033\u305f\u3076\u306e\u5bfe\u89d2\u7dda\u72b6\u306e\u3057\u308f\u306f\u52d5\u8108\u786c\u5316\u306e\u30b5\u30a4\u30f3\u3002AGEs\u84c4\u7a4d\u3068\u306e\u95a2\u9023\u304c\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u8001\u5316\u6291\u5236\u30db\u30eb\u30e2\u30f3Klotho\u306e\u8840\u4e2d\u6fc3\u5ea6\u4f4e\u4e0b\u3068\u3082\u95a2\u4fc2\u3057\u307e\u3059\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u7761\u7720\u6642\u9593\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af<\/strong>\uff1a\u7761\u7720\u4e0d\u8db3\u306f\u7cd6\u4ee3\u8b1d\u3092\u60aa\u5316\u3055\u305bAGEs\u84c4\u7a4d\u3092\u4fc3\u9032\u3002\u77ed\u6642\u9593\u7761\u7720\u8005\u3067\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u767d\u8840\u7403\uff08\u597d\u4e2d\u7403\u30fb\u5358\u7403\uff09\u3068\u306e\u76f8\u95a2<\/strong>\uff1a\u4e00\u822c\u96c6\u56e3\u3067\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u3068\u8840\u4e2d\u597d\u4e2d\u7403\u6570\u30fb\u5358\u7403\u6570\u304c\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u3001AGEs\u304c\u6162\u6027\u708e\u75c7\u72b6\u614b\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u307e\u3059\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u767d\u5185\u969c\u30fb\u7db2\u819c\u75c7<\/strong>\uff1a\u6c34\u6676\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30af\u30ea\u30b9\u30bf\u30ea\u30f3\uff09\u306eAGEs\u5316\u306f\u767d\u5185\u969c\u306e\u4e3b\u8981\u56e0\u306e\u3072\u3068\u3064\u3002<\/p>\n<p style=\"margin: 0;\"><strong>NAFLD\/MASLD\uff08\u8102\u80aa\u809d\uff09<\/strong>\uff1a\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u7531\u6765AGEs\uff08TAGE\uff09\u304c\u809d\u7d30\u80de\u969c\u5bb3\u30fb\u7dda\u7dad\u5316\u306b\u95a2\u4e0e\u3057\u3001\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u904e\u5270\u6442\u53d6\u304c\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<hr \/>\n<h2 id=\"sec9\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">9. AGEs\u3092\u5897\u3084\u30596\u3064\u306e\u751f\u6d3b\u7fd2\u6163 \u2014 1\u4e071\u5343\u4eba\u306e\u65e5\u672c\u4eba\u8abf\u67fb\u304b\u3089<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-37.png\" alt=\"AGEs\u3068\u751f\u6d3b\u7fd2\u6163\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<p>\u82b1\u738b\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u4f1a\u304c\u5168\u56fd\u7d04<strong>1\u4e071,000\u4eba\u306e\u65e5\u672c\u4eba<\/strong>\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3057\u305f\u5927\u898f\u6a21\u8abf\u67fb\uff08Isami F, et al. <em>J Diabetes Investig<\/em>, 2018\uff09\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u751f\u6d3b\u7fd2\u6163\u304c<strong>\u5e74\u9f62\u3068\u306f\u72ec\u7acb\u3057\u3066<\/strong>\u76ae\u819aAGEs\u84c4\u7a4d\u91cf\u306e\u4e0a\u6607\u3068\u6709\u610f\u306b\u76f8\u95a2\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<table style=\"width: 100%; background: #fce4ec; border-left: 6px solid #c2185b; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 12px 0; font-weight: bold; color: #880e4f; font-size: 1.1em;\">AGEs\u3092\u5897\u52a0\u3055\u305b\u308b6\u3064\u306e\u751f\u6d3b\u7fd2\u6163\u30ea\u30b9\u30af\u56e0\u5b50<\/p>\n<p style=\"margin: 0 0 6px 0;\">1. <strong>\u55ab\u7159<\/strong>\uff1a\u30bf\u30d0\u30b3\u7159\u306b\u542b\u307e\u308c\u308bAGEs\u304c\u80ba\u304b\u3089\u5438\u53ce\u3002\u55ab\u7159\u8005\u306f\u975e\u55ab\u7159\u8005\u3088\u308a\u8840\u4e2d\u30fb\u76ae\u819a\u4e2dAGEs\u6fc3\u5ea6\u304c\u6709\u610f\u306b\u9ad8\u5024\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\">2. <strong>\u904b\u52d5\u4e0d\u8db3<\/strong>\uff1a\u904b\u52d5\u306b\u3088\u308b\u8840\u7cd6\u6d88\u8cbb\u306e\u4f4e\u4e0b\u304cAGEs\u751f\u6210\u3092\u4fc3\u9032\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\">3. <strong>\u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9<\/strong>\uff1a\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\uff08\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09\u306b\u3088\u308b\u8840\u7cd6\u4e0a\u6607\u304cAGEs\u751f\u6210\u306b\u5bc4\u4e0e\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\">4. <strong>\u7761\u7720\u4e0d\u8db3<\/strong>\uff1a\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u4f4e\u4e0b\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u6e1b\u5c11\u3092\u4ecb\u3057\u3066AGEs\u84c4\u7a4d\u3092\u4fc3\u9032\u3002<\/p>\n<p style=\"margin: 0 0 6px 0;\">5. <strong>\u671d\u98df\u629c\u304d<\/strong>\uff1a\u6b21\u306e\u98df\u4e8b\u3067\u306e\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u304c\u5897\u5927\u3057\u3001AGEs\u751f\u6210\u304c\u4fc3\u9032\u3002<\/p>\n<p style=\"margin: 0;\">6. <strong>\u7518\u3044\u7269\u30fb\u52a0\u5de5\u8089\u30fb\u63da\u3052\u7269\u306e\u904e\u5270\u6442\u53d6<\/strong>\uff1a\u5916\u56e0\u6027AGEs\u306e\u76f4\u63a5\u7684\u306a\u6442\u53d6\u6e90\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>AGEs\u30b9\u30b3\u30a2\u306f\u300c<strong>\u751f\u6d3b\u7fd2\u6163\u306e\u6210\u7e3e\u8868<\/strong>\u300d\u3067\u3059\u3002\u4e0a\u8a18\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u306f\u4e00\u3064\u3072\u3068\u3064\u306f\u5c0f\u3055\u304f\u898b\u3048\u3066\u3082\u3001\u8907\u5408\u7684\u306b\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u8001\u5316\u3092\u5927\u304d\u304f\u52a0\u901f\u3055\u305b\u307e\u3059\u3002<\/p>\n<hr \/>\n<h2 id=\"sec10\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">10. AGEs\u84c4\u7a4d\u3092\u9632\u30507\u3064\u306e\u5b9f\u8df5\u7684\u5bfe\u7b56<\/h2>\n<table style=\"width: 100%; background: #fff3e0; border-left: 6px solid #f57c00; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0; line-height:1.7;\"><strong style=\"color:#e65100;\">\u5b9f\u8df5\u7de8\u306f\u3053\u3061\u3089\uff1a<\/strong>\u672c\u7ae0\u3067\u306f7\u3064\u306e\u5bfe\u7b56\u3092\u8981\u70b9\u3067\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002\u3088\u308a\u8a73\u3057\u3044\u5b9f\u8df5\u30ac\u30a4\u30c9\uff08\u5177\u4f53\u7684\u306a\u8abf\u7406\u6cd5\u3001\u9ad8AGE\/\u4f4eAGE\u98df\u54c1\u30ea\u30b9\u30c8\u3001\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528\u3001\u5f53\u9662\u3067\u306e\u500b\u5225\u5316\u30a2\u30d7\u30ed\u30fc\u30c1\uff09\u306f\u3001<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/ages-anti-glycation-practical-guide-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#e65100;\"><strong>\u300cAGEs\uff08\u7cd6\u5316\uff09\u5bfe\u7b56\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9\uff5c\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u30fb\u85ac\u5264\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u300d<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-26.png\" alt=\"AGEs\u5bfe\u7b56\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b561\uff1a\u8abf\u7406\u6cd5\u3092\u5de5\u592b\u3059\u308b \u2014 \u300c\u713c\u304f\u30fb\u63da\u3052\u308b\u300d\u3088\u308a\u300c\u716e\u308b\u30fb\u84b8\u3059\u300d<\/h3>\n<p>\u9ad8\u6e29\u8abf\u7406\u306fAGEs\u751f\u6210\u3092\u6307\u6570\u95a2\u6570\u7684\u306b\u5897\u52a0\u3055\u305b\u307e\u3059\u3002\u63da\u3052\u7269\uff08170\u301c200\u2103\uff09\u3084\u30aa\u30fc\u30d6\u30f3\u713c\u304d\uff08200\u2103\u4ee5\u4e0a\uff09\u306b\u5bfe\u3057\u3001\u8339\u3067\u308b\u30fb\u84b8\u3059\u30fb\u716e\u308b\u8abf\u7406\u6cd5\u306f\u7d04100\u2103\u306b\u3068\u3069\u307e\u308a\u3001AGEs\u751f\u6210\u3092\u5927\u5e45\u306b\u6291\u5236\u3067\u304d\u307e\u3059\u3002<strong>\u9162\u3084\u30ec\u30e2\u30f3\u6c41\u306a\u3069\u306e\u9178\u6027\u8abf\u5473\u6599<\/strong>\u3092\u4f7f\u3063\u305f\u30de\u30ea\u30cd\u3082AGEs\u751f\u6210\u6291\u5236\u306b\u6709\u52b9\u3067\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b562\uff1a\u98df\u3079\u308b\u9806\u756a\u3092\u5b88\u308b \u2014 \u30d9\u30b8\u30bf\u30d6\u30eb\u30d5\u30a1\u30fc\u30b9\u30c8<\/h3>\n<p><strong>\u98df\u7269\u7e4a\u7dad<\/strong>\uff08\u91ce\u83dc\u30fb\u6d77\u85fb\u30fb\u304d\u306e\u3053\u985e\uff09\u2192 <strong>\u30bf\u30f3\u30d1\u30af\u8cea<\/strong>\uff08\u8089\u30fb\u9b5a\uff09\u2192 <strong>\u70ad\u6c34\u5316\u7269<\/strong>\uff08\u3054\u306f\u3093\u30fb\u30d1\u30f3\uff09\u306e\u9806\u756a\u3067\u98df\u3079\u308b\u3053\u3068\u3067\u3001\u98df\u5f8c\u8840\u7cd6\u5024\u306e\u6025\u4e0a\u6607\u3092\u6291\u3048\u3001AGEs\u751f\u6210\u3092\u4f4e\u6e1b\u3067\u304d\u307e\u3059\u3002\u3086\u3063\u304f\u308a\u3088\u304f\u565b\u3080\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b563\uff1a\u4f4eGI\u98df\u54c1\u3092\u9078\u3076<\/h3>\n<p>GI\u5024\uff08\u98df\u54c1\u306e\u8840\u7cd6\u4e0a\u6607\u6307\u6570\uff09\u304c55\u4ee5\u4e0b\u306e\u4f4eGI\u98df\u54c1\uff08\u5927\u8c46\u88fd\u54c1\u3001\u5168\u7c92\u7a40\u7269\u3001\u30ca\u30c3\u30c4\u985e\uff09\u3092\u9078\u3076\u3053\u3068\u3067\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u30b9\u30d1\u30a4\u30af\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b564\uff1a\u98df\u5f8c\u306e\u904b\u52d5\u3092\u7fd2\u6163\u306b<\/h3>\n<p>\u98df\u5f8c20\u301c30\u5206\u306e\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3067\u8840\u7cd6\u5024\u306e\u4e0a\u6607\u3092\u7a4f\u3084\u304b\u306b\u3057\u3001AGEs\u751f\u6210\u3092\u6291\u5236\u3067\u304d\u307e\u3059\u3002\u8840\u7cd6\u5024\u304c\u6700\u3082\u4e0a\u304c\u308b\u306e\u306f\u98df\u5f8c\u7d041\u6642\u9593\u3067\u3042\u308a\u3001\u3053\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u306e\u904b\u52d5\u304c\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b565\uff1a\u6297\u9178\u5316\u7269\u8cea\u3092\u7a4d\u6975\u7684\u306b\u6442\u53d6\u3059\u308b<\/h3>\n<p>\u300c\u9178\u5316\u300d\u3068\u300c\u7cd6\u5316\u300d\u306f\u5bc6\u63a5\u306b\u95a2\u4fc2\u3057\u3001\u540c\u6642\u306b\u9032\u884c\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<strong>\u6297\u9178\u5316\u7269\u8cea\u306e\u6442\u53d6<\/strong>\u304c\u7cd6\u5316\u6291\u5236\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u7dd1\u9ec4\u8272\u91ce\u83dc\uff08\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u3001\u307b\u3046\u308c\u3093\u8349\u3001\u30c8\u30de\u30c8\uff09\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u30b9\u30d7\u30e9\u30a6\u30c8\u3001\u30de\u30a4\u30bf\u30b1\u3001\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306a\u3069\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b566\uff1a\u5341\u5206\u306a\u7761\u7720\u3068\u7981\u7159<\/h3>\n<p>\u8cea\u306e\u9ad8\u3044\u7761\u7720\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u7dad\u6301\u3057\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3066AGEs\u84c4\u7a4d\u3092\u6291\u5236\u3057\u307e\u3059\u3002<strong>\u7981\u7159<\/strong>\u306fAGEs\u306e\u5916\u56e0\u6027\u4f9b\u7d66\u3092\u65ad\u3064\u6700\u3082\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u5bfe\u7b567\uff1a\u5b9a\u671f\u7684\u306aAGEs\u6e2c\u5b9a\u3067\u300c\u898b\u3048\u308b\u5316\u300d<\/h3>\n<p>AGEs\u6e2c\u5b9a\u3092\u5b9a\u671f\u7684\u306b\u884c\u3046\u3053\u3068\u3067\u3001\u3054\u81ea\u8eab\u306e\u8001\u5316\u5ea6\u30fb\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u5ea6\u3092\u5ba2\u89b3\u7684\u306b\u628a\u63e1\u3067\u304d\u307e\u3059\u3002\u300c<strong>\u898b\u3048\u308b\u5316<\/strong>\u300d\u3059\u308b\u3053\u3068\u304c\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u306e\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u7dad\u6301\u306b\u7e4b\u304c\u308a\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-34.png\" alt=\"\u6297\u9178\u5316\u7269\u8cea\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<p>\u5f53\u9662\u306e\u7ba1\u7406\u6804\u990a\u58eb\u304c\u3001AGEs\u5bfe\u7b56\u306b\u52b9\u679c\u7684\u306a\u30ec\u30b7\u30d4\u3092\u516c\u958b\u3057\u3066\u3044\u307e\u3059\u3002\u305c\u3072\u53c2\u8003\u306b\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e6%a0%84%e9%a4%8a%e7%9b%b8%e8%ab%87\/%e6%a0%84%e9%a4%8a%e6%8c%87%e5%b0%8e%e3%83%ac%e3%82%b7%e3%83%92\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#00796b;\"><strong>\u7ba1\u7406\u6804\u990a\u58eb\u304a\u3059\u3059\u3081\u30ec\u30b7\u30d4\u306f\u3053\u3061\u3089 \u2192<\/strong><\/a><\/p>\n<hr \/>\n<h2 id=\"sec11\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">11. \u5f53\u9662\u306eAGEs\u6e2c\u5b9a\u691c\u67fb\u30fbd-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-33.png\" alt=\"AGEs\u6e2c\u5b9a\u5668\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">\u691c\u67fb\u306e\u539f\u7406\uff1a\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08SAF\uff09\u6e2c\u5b9a<\/h3>\n<p>\u5f53\u9662\u306eAGEs\u6e2c\u5b9a\u306f\u3001<strong>\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\uff08Skin Autofluorescence\uff1aSAF\uff09<\/strong>\u3092\u5229\u7528\u3057\u305f\u975e\u4fb5\u8972\u7684\u306a\u691c\u67fb\u3067\u3059\u3002\u76ae\u819a\u306b\u7279\u5b9a\u306e\u6ce2\u9577\uff08300\u301c420nm\uff09\u306e\u7d2b\u5916\u5149\u3092\u7167\u5c04\u3059\u308b\u3068\u3001\u7d44\u7e54\u4e2d\u306b\u84c4\u7a4d\u3057\u305f\u86cd\u5149\u6027AGEs\uff08\u4e3b\u306b\u30da\u30f3\u30c8\u30b7\u30b8\u30f3\uff09\u304c420\u301c600nm\u306e\u86cd\u5149\u3092\u767a\u3057\u307e\u3059\u3002\u3053\u306e\u86cd\u5149\u5f37\u5ea6\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u3067\u3001AGEs\u84c4\u7a4d\u91cf\u3092\u63a8\u5b9a\u3057\u307e\u3059\u3002\u76ae\u819a\u751f\u691c\u3067\u8a55\u4fa1\u3057\u305fAGEs\u91cf\u3068\u306e\u76f8\u95a2\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b<strong>\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u691c\u67fb\u6cd5<\/strong>\u3067\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #e3f2fd; border-left: 6px solid #1976d2; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 12px 0; font-weight: bold; color: #1565c0; font-size: 1.1em;\">\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\uff08AGEs\u6e2c\u5b9a\uff09\u306e\u6982\u8981<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u691c\u67fb\u65b9\u6cd5<\/strong>\uff1a\u8155\u3092\u6e2c\u5b9a\u5668\u306b\u4e57\u305b\u308b\u3060\u3051\uff08\u63a1\u8840\u4e0d\u8981\uff09<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u6240\u8981\u6642\u9593<\/strong>\uff1a\u7d0412\u79d2<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>AGEs\u6e2c\u5b9a\u6599\u91d1<\/strong>\uff1a<strong style=\"color: #c62828; font-size: 1.15em;\">1,000\u5186\uff08\u7a0e\u8fbc\uff09<\/strong><\/p>\n<p style=\"margin: 0 0 6px 0;\">\u203b\u5225\u9014\u3001\u8a3a\u5bdf\u6599<strong>3,000\u5186\uff08\u7a0e\u8fbc\uff09<\/strong>\u304c\u304b\u304b\u308a\u307e\u3059<\/p>\n<p style=\"margin: 0 0 6px 0;\"><strong>\u75db\u307f<\/strong>\uff1a\u306a\u3057\uff08\u5b8c\u5168\u975e\u4fb5\u8972\uff09<\/p>\n<p style=\"margin: 0;\"><strong>\u5bfe\u8c61<\/strong>\uff1a\u5e74\u9f62\u3092\u554f\u308f\u305a\u3069\u306a\u305f\u3067\u3082\u6e2c\u5b9a\u53ef\u80fd\uff08\u5c0f\u5150\u3082\u53ef\uff09<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u5b9a\u671f\u7684\u306b\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u3069\u306e\u7a0b\u5ea6\u8001\u5316\u304c\u9032\u3093\u3067\u3044\u308b\u304b\u3001\u307e\u305f\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u52b9\u679c\u304c\u3069\u306e\u7a0b\u5ea6\u73fe\u308c\u3066\u3044\u308b\u304b\u306e\u6307\u6a19\u306b\u306a\u308a\u307e\u3059\u30023\u301c6\u304b\u6708\u3054\u3068\u306e\u518d\u6e2c\u5b9a\u3092\u304a\u3059\u3059\u3081\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<table style=\"width: 100%; background: #e8f5e9; border-left: 6px solid #2e7d32; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0 0 10px 0; font-weight: bold; color: #1b5e20; font-size: 1.1em;\">\u53d7\u8a3a\u524d\u30c1\u30a7\u30c3\u30af\u30ea\u30b9\u30c8<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 HbA1c\u30fb\u7a7a\u8179\u6642\u8840\u7cd6\u304c\u5883\u754c\u57df\u301c\u7cd6\u5c3f\u75c5\u7bc4\u56f2<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 \u3054\u5bb6\u65cf\u306b\u7cd6\u5c3f\u75c5\u30fb\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\u30fb\u8a8d\u77e5\u75c7\u306e\u65b9\u304c\u3044\u308b<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 \u63da\u3052\u7269\u30fb\u7518\u3044\u7269\u30fb\u52a0\u5de5\u8089\u304c\u597d\u304d<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 \u55ab\u7159\u6b74\u304c\u3042\u308b\uff08\u307e\u305f\u306f\u73fe\u55ab\u7159\uff09<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 \u904b\u52d5\u4e0d\u8db3\u30fb\u7761\u7720\u4e0d\u8db3\u3092\u611f\u3058\u3066\u3044\u308b<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 \u808c\u306e\u304f\u3059\u307f\u30fb\u3057\u308f\u30fb\u305f\u308b\u307f\u304c\u6c17\u306b\u306a\u308b<\/p>\n<p style=\"margin: 0 0 5px 0;\">\u25a1 \u6162\u6027\u7684\u306a\u75b2\u52b4\u611f\u30fb\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u304c\u3042\u308b<\/p>\n<p style=\"margin: 0;\">\u25a1 \u5065\u5eb7\u8a3a\u65ad\u306e\u6570\u5024\u306f\u3044\u3044\u304c\u300c\u8001\u5316\u300d\u3092\u5ba2\u89b3\u7684\u306b\u8a55\u4fa1\u3057\u305f\u3044<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<h3 style=\"color: #00796b; margin-top: 30px;\">d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30fbd-Gs\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\u306e\u3054\u6848\u5185<\/h3>\n<p>\u5f53\u9662\u3067\u306f\u3001\u7cd6\u5316\u5bfe\u7b56\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%90d-gs%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%80%91%e3%80%90d-gs%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%af%e3%83%aa%e3%83%bc%e3%83%a0%e3%80%91%e8%b2%a9%e5%a3%b2\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#00796b;\"><strong>\u3010d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3011\u3010d-Gs\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\u3011<\/strong><\/a>\u3092\u53d6\u308a\u6271\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u8a73\u7d30\u306f<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%90d-gs%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%80%91%e3%80%90d-gs%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%af%e3%83%aa%e3%83%bc%e3%83%a0%e3%80%91%e8%b2%a9%e5%a3%b2\/\" target=\"_blank\" rel=\"noopener\" style=\"color:#00796b;\"><strong>\u3053\u3061\u3089\u306e\u30da\u30fc\u30b8<\/strong><\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/%e3%80%90d-gs%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%80%91%e3%80%90d-gs%e3%82%b9%e3%82%ad%e3%83%b3%e3%82%af%e3%83%aa%e3%83%bc%e3%83%a0%e3%80%91%e8%b2%a9%e5%a3%b2\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2025\/05\/image-2.jpg\" alt=\"d-Gs\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30fb\u30b9\u30ad\u30f3\u30af\u30ea\u30fc\u30e0\" style=\"max-width: 100%; height: auto; display: block; margin: 20px auto;\" \/><\/a><\/p>\n<table style=\"width: 100%; background: #fff3e0; border-left: 6px solid #f57c00; border-radius: 6px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 18px 22px;\">\n<p style=\"margin: 0; line-height:1.7;\"><strong style=\"color:#e65100;\">\u59c9\u59b9\u9662\u306e\u5c02\u9580\u5916\u6765\u3068\u306e\u9023\u643a\uff1a<\/strong>\u7f8e\u5bb9\u76ae\u819a\u79d1\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\uff08\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u30fb\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u70b9\u6ef4\u30fb\u30d7\u30e9\u30bb\u30f3\u30bf\u30fbPURE FLOW\u30fb\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u30fbVISIA\u808c\u8a3a\u65ad\u306a\u3069\uff09\u3092\u3054\u5e0c\u671b\u306e\u65b9\u306b\u306f\u3001<strong>\u4e94\u826f\u4f1a\u30af\u30ea\u30cb\u30c3\u30af\u767d\u91d1\u9ad8\u8f2a\uff082F\u7f8e\u5bb9\u76ae\u819a\u79d1\u30fb\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u5916\u6765\uff09<\/strong>\u3078\u306e\u3054\u7d39\u4ecb\u3082\u53ef\u80fd\u3067\u3059\u3002\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u60c5\u5831\u5171\u6709\u3057\u306a\u304c\u3089\u3001\u5185\u79d1\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u7f8e\u5bb9\u533b\u7642\u3092\u4e00\u4f53\u3067\u9032\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<hr \/>\n<h2 id=\"sec12\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">12. \u3088\u304f\u3042\u308b\u3054\u8cea\u554f\uff08FAQ\uff09<\/h2>\n<h3 style=\"color: #00796b; margin-top: 30px;\">Q1. AGEs\u691c\u67fb\u306f\u4fdd\u967a\u9069\u7528\u3055\u308c\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\uff08\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u6e2c\u5b9a\uff09\u306f<strong>\u81ea\u7531\u8a3a\u7642<\/strong>\u3068\u306a\u308a\u307e\u3059\u3002AGEs\u6e2c\u5b9a1,000\u5186\uff08\u7a0e\u8fbc\uff09\uff0b\u8a3a\u5bdf\u65993,000\u5186\uff08\u7a0e\u8fbc\uff09\u3067\u3059\u3002\u7cd6\u5c3f\u75c5\u30fb\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u3067\u4fdd\u967a\u8a3a\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u65b9\u3082\u3001\u305d\u306e\u65e5\u306b\u540c\u6642\u306b\u53d7\u3051\u3066\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">Q2. HbA1c\u304c\u6b63\u5e38\u3067\u3082AGEs\u304c\u9ad8\u3044\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3001\u5341\u5206\u306b\u3042\u308a\u5f97\u307e\u3059\u3002HbA1c\u306f\u904e\u53bb1\u301c2\u304b\u6708\u306e\u5e73\u5747\u8840\u7cd6\u3092\u53cd\u6620\u3057\u307e\u3059\u304c\u3001AGEs\u306f<strong>\u9577\u671f\u9593\uff08\u5e74\u5358\u4f4d\uff09<\/strong>\u306e\u7cd6\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u84c4\u7a4d\u3092\u53cd\u6620\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u98df\u751f\u6d3b\uff08\u52a0\u5de5\u98df\u54c1\u30fb\u63da\u3052\u7269\u306e\u6442\u53d6\uff09\u3001\u55ab\u7159\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u6162\u6027\u708e\u75c7\u306a\u3069\u3001\u8840\u7cd6\u4ee5\u5916\u306e\u8981\u56e0\u3067\u3082AGEs\u306f\u5897\u52a0\u3057\u307e\u3059\u3002\u300c\u8840\u6db2\u691c\u67fb\u306f\u554f\u984c\u306a\u3044\u306e\u306b\u4f53\u8abf\u304c\u512a\u308c\u306a\u3044\u300d\u3068\u3044\u3046\u65b9\u3053\u305d\u3001AGEs\u6e2c\u5b9a\u306e\u610f\u7fa9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">Q3. AGEs\u306f\u4e00\u5ea6\u84c4\u7a4d\u3057\u305f\u3089\u6e1b\u3089\u305b\u306a\u3044\u306e\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u30b3\u30e9\u30fc\u30b2\u30f3\u306a\u3069\u534a\u6e1b\u671f\u306e\u9577\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u84c4\u7a4d\u3057\u305fAGEs\u306f\u5206\u89e3\u304c\u56f0\u96e3\u3067\u3059\u304c\u3001<strong>\u65b0\u305f\u306a\u84c4\u7a4d\u3092\u6291\u5236\u3059\u308b\u3053\u3068<\/strong>\u3068\u3001<strong>\u7d30\u80de\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3067\u5f90\u3005\u306b\u7f6e\u304d\u63db\u308f\u308b\u7d44\u7e54\uff08\u76ae\u819a\u30fb\u8840\u7ba1\u5185\u76ae\u306a\u3069\uff09\u3067\u306f\u6642\u9593\u3092\u304b\u3051\u3066\u6539\u5584\u304c\u898b\u3089\u308c\u308b<\/strong>\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u5f53\u9662\u3067\u3082\u3001\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u5f8c3\u301c6\u304b\u6708\u3067SAF\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u65b9\u304c\u591a\u304f\u3044\u3089\u3063\u3057\u3083\u3044\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">Q4. \u304a\u5b50\u3055\u3093\u3082\u691c\u67fb\u3067\u304d\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3001\u5e74\u9f62\u3092\u554f\u308f\u305a\u6e2c\u5b9a\u53ef\u80fd\u3067\u3059\u3002\u5f53\u9662\u306f<strong>\u5c0f\u5150\u79d1\u4f75\u8a2d<\/strong>\u3067\u3059\u306e\u3067\u3001\u80a5\u6e80\u50be\u5411\u306e\u304a\u5b50\u3055\u307e\u30fb\u7518\u3044\u7269\u306e\u6442\u53d6\u304c\u591a\u3044\u304a\u5b50\u3055\u307e\u306e\u65e9\u671f\u4ecb\u5165\u3068\u3057\u3066\u3001\u3054\u5bb6\u65cf\u3067\u306e\u3054\u53d7\u8a3a\u3082\u6b53\u8fce\u3057\u3066\u304a\u308a\u307e\u3059\u3002\u571f\u66dc\u5348\u524d\u3082\u8a3a\u7642\u3057\u3066\u304a\u308a\u307e\u3059\u306e\u3067\u3001\u3054\u5bb6\u65cf\u306e\u90fd\u5408\u306b\u5408\u308f\u305b\u3084\u3059\u3044\u304b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">Q5. \u3069\u306e\u304f\u3089\u3044\u306e\u9593\u9694\u3067\u518d\u691c\u67fb\u3059\u308b\u306e\u304c\u826f\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3084\u6cbb\u7642\u4ecb\u5165\u306e\u52b9\u679c\u3092\u78ba\u8a8d\u3059\u308b\u5834\u5408\u306f<strong>3\u301c6\u304b\u6708\u5f8c<\/strong>\u3001\u73fe\u72b6\u7dad\u6301\u30fb\u7d4c\u904e\u89b3\u5bdf\u306e\u5834\u5408\u306f<strong>1\u5e74\u306b1\u56de<\/strong>\u3092\u76ee\u5b89\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u30fbCKD\u30fb\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u304a\u6301\u3061\u306e\u65b9\u306f3\u301c6\u304b\u6708\u6bce\u306e\u8a55\u4fa1\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002<\/p>\n<h3 style=\"color: #00796b; margin-top: 30px;\">Q6. \u6e21\u822a\u524d\u30fb\u5065\u5eb7\u8a3a\u65ad\u3068\u4e00\u7dd2\u306b\u53d7\u3051\u3089\u308c\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3001\u53ef\u80fd\u3067\u3059\u3002\u5f53\u9662\u3067\u306f\u6e21\u822a\u533b\u5b66\u5916\u6765\u30fb\u5065\u5eb7\u8a3a\u65ad\u3068\u7d44\u307f\u5408\u308f\u305b\u3066AGEs\u6e2c\u5b9a\u3092\u884c\u3046\u3053\u3068\u3082\u591a\u304f\u3042\u308a\u307e\u3059\u3002\u3088\u308a\u9ad8\u5ea6\u306a\u6e21\u822a\u533b\u5b66\u76f8\u8ac7\uff08\u9ec4\u71b1\u30fb\u72c2\u72ac\u75c5\u306a\u3069\uff09\u304c\u5fc5\u8981\u306a\u5834\u5408\u306f\u3001\u59c9\u59b9\u9662\u306e<strong>\u4e94\u826f\u4f1a\u30af\u30ea\u30cb\u30c3\u30af\u767d\u91d1\u9ad8\u8f2a<\/strong>\uff08\u6e21\u822a\u533b\u5b66\u8a8d\u5b9a\u533b2\u540d\u5728\u7c4d\uff09\u3068\u9023\u643a\u3057\u3066\u3054\u5bfe\u5fdc\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<hr \/>\n<h2 id=\"sec13\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">13. \u95a2\u9023\u8a18\u4e8b\u30fb\u30b0\u30eb\u30fc\u30d7\u5185\u9023\u643a<\/h2>\n<table style=\"width: 100%; background: #f1f8f6; border: 2px solid #80cbc4; border-radius: 8px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 22px 26px;\">\n<p style=\"margin: 0 0 16px 0; font-weight: bold; color: #004d40; font-size: 1.15em; padding-bottom: 10px; border-bottom: 2px solid #00796b;\">\u95a2\u9023\u8a18\u4e8b\uff5c\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\uff08\u7530\u5712\u8abf\u5e03\uff09<\/p>\n<table style=\"width: 100%; border-collapse: collapse;\">\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/ages-anti-glycation-practical-guide-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">AGEs\uff08\u7cd6\u5316\uff09\u5bfe\u7b56\u306e\u5b9f\u8df5\u30ac\u30a4\u30c9\uff5c\u98df\u4e8b\u30fb\u8abf\u7406\u6cd5\u30fb\u904b\u52d5\u30fb\u85ac\u5264\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u8abf\u7406\u6cd5\u30fb\u98df\u6750\u9078\u3073\u30fb\u98df\u5f8c\u8840\u7cd6\u7ba1\u7406\u30fb\u7cd6\u5c3f\u75c5\u85ac\u306e\u6297\u7cd6\u5316\u4f5c\u7528\u307e\u3067\u3092\u4f53\u7cfb\u7684\u306b\u89e3\u8aac<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/diabetes-treatment-metformin-sglt2-cgm-geroscience-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306e\u6700\u524d\u7dda\uff5c\u30e1\u30c8\u30db\u30eb\u30df\u30f3\u30fbSGLT2\u30fbCGM\u500b\u5225\u5316\uff0b\u6297\u8001\u5316\u306e\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u7cd6\u5c3f\u75c5\u85ac\u306e\u9078\u629e\u30fbCGM\u306b\u3088\u308b\u500b\u5225\u5316\u30fbGeroscience\uff08\u8001\u5316\u533b\u79d1\u5b66\uff09\u306e\u8996\u70b9<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/metabolic-syndrome-diabetes-progression-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u30e1\u30bf\u30dc\u304b\u3089\u7cd6\u5c3f\u75c5\u3078\uff5c2024\u5e74\u65b0\u57fa\u6e96\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3092\u5fb9\u5e95\u89e3\u8aac<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u5185\u81d3\u8102\u80aa\u30fbsd-LDL\u30fb\u96a0\u308c\u30e1\u30bf\u30dc\u3068AGE\u84c4\u7a4d\u306e\u60aa\u5faa\u74b0<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/diabetes-family-history-fh-2026\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u89aa\u304c\u7cd6\u5c3f\u75c5\u3060\u3068\u81ea\u5206\u3082\uff1f\uff5c\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u4eba\u306e\u65e9\u671f\u5bfe\u7b56\u30fb\u62e1\u5927\u8102\u8cea\u691c\u67fb\u30fbFH\u3092\u89e3\u8aac<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u5bb6\u65cf\u6b74\u306e\u3042\u308b\u65b9\u306e\u65e9\u671f\u5bfe\u7b56\u3001\u62e1\u5927\u8102\u8cea\u691c\u67fb\u3001\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff08FH\uff09<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e6%a0%84%e9%a4%8a%e7%9b%b8%e8%ab%87\/%e6%a0%84%e9%a4%8a%e6%8c%87%e5%b0%8e%e3%83%ac%e3%82%b7%e3%83%92\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u7ba1\u7406\u6804\u990a\u58eb\u304a\u3059\u3059\u3081\uff5c\u6297\u7cd6\u5316\u30ec\u30b7\u30d4\u96c6<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u6bce\u65e5\u306e\u98df\u5353\u3067\u5b9f\u8df5\u3067\u304d\u308b\u4f4eAGE\u8abf\u7406\u30ec\u30b7\u30d4<\/span><\/td>\n<\/tr>\n<\/table>\n<\/td>\n<\/tr>\n<\/table>\n<table style=\"width: 100%; background: #f1f8f6; border: 2px solid #80cbc4; border-radius: 8px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 22px 26px;\">\n<p style=\"margin: 0 0 16px 0; font-weight: bold; color: #004d40; font-size: 1.15em; padding-bottom: 10px; border-bottom: 2px solid #00796b;\">\u95a2\u9023\u8a18\u4e8b\uff5c\u4e94\u826f\u4f1a\u30af\u30ea\u30cb\u30c3\u30af\u767d\u91d1\u9ad8\u8f2a\uff08\u6e2f\u533a\uff09<\/p>\n<table style=\"width: 100%; border-collapse: collapse;\">\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/goryokai-shirokanetakanawa.jp\/blog\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u5916\u6765\u30fb\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u30fb\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u70b9\u6ef4<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">2F\u7f8e\u5bb9\u76ae\u819a\u79d1\u306e\u6297\u7cd6\u5316\u30fb\u6297\u9178\u5316\u70b9\u6ef4\u30e1\u30cb\u30e5\u30fc\u3068\u533b\u7642\u75e9\u8eab<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/goryokai-shirokanetakanawa.jp\/blog\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">VISIA\u808c\u8a3a\u65ad\u30fb\u30d4\u30b3\u30ec\u30fc\u30b6\u30fc\u30fbPURE FLOW\uff082F\u7f8e\u5bb9\u76ae\u819a\u79d1\uff09<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u76ae\u819aAGEs\u306b\u3088\u308b\u30b7\u30df\u30fb\u304f\u3059\u307f\u3078\u306e\u7f8e\u5bb9\u533b\u7642\u7684\u30a2\u30d7\u30ed\u30fc\u30c1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/goryokai-shirokanetakanawa.jp\/blog\/\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u7cd6\u5c3f\u75c5\u5185\u79d1\u30fb\u5185\u8996\u93e1\u30fb\u5065\u5eb7\u8a3a\u65ad\u30fb\u6e21\u822a\u533b\u5b66\uff081F\u5185\u79d1\uff09<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u6e21\u822a\u533b\u5b66\u8a8d\u5b9a\u533b2\u540d\u306b\u3088\u308b\u6d77\u5916\u8d74\u4efb\u30fb\u51fa\u5f35\u524d\u306e\u5305\u62ec\u30b5\u30dd\u30fc\u30c8<\/span><\/td>\n<\/tr>\n<\/table>\n<\/td>\n<\/tr>\n<\/table>\n<table style=\"width: 100%; background: #f1f8f6; border: 2px solid #80cbc4; border-radius: 8px; margin: 25px 0;\">\n<tr>\n<td style=\"padding: 22px 26px;\">\n<p style=\"margin: 0 0 16px 0; font-weight: bold; color: #004d40; font-size: 1.15em; padding-bottom: 10px; border-bottom: 2px solid #00796b;\">\u95a2\u9023\u8a18\u4e8b\uff5c\u4e94\u826f\u30d5\u30a1\u30df\u30ea\u30fc\u30af\u30ea\u30cb\u30c3\u30af \u30bb\u30f3\u30bf\u30fc\u5357\uff08\u6a2a\u6d5c\u5e02\u90fd\u7b51\u533a\uff09<\/p>\n<table style=\"width: 100%; border-collapse: collapse;\">\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/goryo-family.clinic\/diabetes-dementia\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u8a8d\u77e5\u75c7\u5916\u6765\u30fbMIND\u98df\u30fb\u6297\u52a0\u9f62\u306e\u30af\u30ed\u30b9\u30dd\u30a4\u30f3\u30c8<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u7cd6\u5c3f\u75c5\u00d7\u8a8d\u77e5\u75c7\u00d7\u6297\u52a0\u9f62\u306e3\u8ef8\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u3092\u89e3\u8aac<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/goryo-family.clinic\/elderly-diabetes-frailty\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u9ad8\u9f62\u8005\u7cd6\u5c3f\u75c5\u30fb\u30d5\u30ec\u30a4\u30eb\u30fb\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u5916\u6765<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u300e\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u30d5\u30ec\u30a4\u30eb\u6804\u990a\u7ba1\u7406\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32025\u300f\u306b\u57fa\u3065\u304f\u5b9f\u8df5\u6307\u5c0e<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 8px 0; vertical-align: top; width: 28px; color: #00796b; font-weight: bold;\">&#x25b6;<\/td>\n<td style=\"padding: 8px 0;\"><a href=\"https:\/\/goryo-family.clinic\/hypertension-jsh2025\" target=\"_blank\" rel=\"noopener\" style=\"color: #00796b; text-decoration: none; font-weight: bold;\">\u9ad8\u8840\u5727\u30fb\u8102\u8cea\u7570\u5e38\u75c7\uff08JSH2025\u5bfe\u5fdc\uff09\u30fb\u982d\u75db\u5916\u6765<\/a><br \/><span style=\"font-size: 0.92em; color: #555;\">\u8840\u7ba1\u8001\u5316\u30fb\u52d5\u8108\u786c\u5316\u3092\u591a\u8ef8\u3067\u8a55\u4fa1\u30fb\u6cbb\u7642<\/span><\/td>\n<\/tr>\n<\/table>\n<\/td>\n<\/tr>\n<\/table>\n<p>\u4e94\u826f\u4f1a\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u7530\u5712\u8abf\u5e03\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\u3001\u6e2f\u533a\u306e\u4e94\u826f\u4f1a\u30af\u30ea\u30cb\u30c3\u30af\u767d\u91d1\u9ad8\u8f2a\u3001\u6a2a\u6d5c\u5e02\u90fd\u7b51\u533a\u306e\u4e94\u826f\u30d5\u30a1\u30df\u30ea\u30fc\u30af\u30ea\u30cb\u30c3\u30af\u30bb\u30f3\u30bf\u30fc\u5357\u304c\u9023\u643a\u3057\u3001\u60a3\u8005\u3055\u307e\u306e\u30e9\u30a4\u30d5\u30b9\u30c6\u30fc\u30b8\u3084\u8ee2\u5c45\u30fb\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5909\u5316\u306b\u5408\u308f\u305b\u3066\u3001<strong>\u540c\u3058\u30b0\u30eb\u30fc\u30d7\u5185\u3067\u7d99\u7d9a\u8a3a\u7642<\/strong>\u304c\u53d7\u3051\u3089\u308c\u308b\u4f53\u5236\u3092\u6574\u3048\u3066\u304a\u308a\u307e\u3059\u3002AGE\u5bfe\u7b56\u306f\u305d\u306e\u57fa\u76e4\u3068\u306a\u308b\u300c\u8001\u5316\u3092\u6e2c\u308a\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u300d\u5171\u901a\u30c4\u30fc\u30eb\u3067\u3059\u3002<\/p>\n<hr \/>\n<h2 id=\"sec_ref\" style=\"color: #004d40; border-bottom: 3px solid #00796b; padding-bottom: 8px; margin-top: 40px;\">\u53c2\u8003\u6587\u732e<\/h2>\n<ol style=\"line-height: 1.9; font-size: 0.95em;\">\n<li>Differential impact of advanced glycation end-products on cardiovascular risk across patient populations measured by skin autofluorescence: a meta-analysis. <em>European Journal of Medical Research<\/em>. 2026.<\/li>\n<li>Association between skin autofluorescence and all-cause mortality, cardiovascular mortality and cardiovascular disease: a systematic review and meta-analysis. <em>Clinical Research in Cardiology<\/em>. 2025.<\/li>\n<li>Advanced Glycation End Products in Disease Development and Potential Interventions. <em>PMC12024296<\/em>. 2025.<\/li>\n<li>Synthetic and Natural Agents Targeting Advanced Glycation End-Products for Skin Anti-Aging: A Comprehensive Review. <em>Antioxidants<\/em>. 2025;14(4):498.<\/li>\n<li>Are Advanced Glycation End-Products and Skin Autofluorescence Associated with E-Selectin and Pulse Wave Velocity as Markers of Atherosclerosis Risk in Children with Obesity? <em>Int J Mol Sci<\/em>. 2025;26(20):9966.<\/li>\n<li>Waqas K, et al. Skin Autofluorescence, a Noninvasive Biomarker of Advanced Glycation End-products, Is Associated With Frailty: The Rotterdam Study. <em>J Gerontol A Biol Sci Med Sci<\/em>. 2022;77(10):2032-2039.<\/li>\n<li>Waqas K, et al. Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Sarcopenia. <em>J Clin Endocrinol Metab<\/em>. 2022;107(2):e793-e803.<\/li>\n<li>Waqas K, et al. Skin Autofluorescence Is Associated With Prevalent Vertebral and Major Osteoporotic Fractures: The Rotterdam Study. <em>J Bone Miner Res<\/em>. 2020;35(10):1904-1913.<\/li>\n<li>Eriksson MD, et al. Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms &#8211; Findings from Helsinki Birth Cohort Study. <em>J Psychosom Res<\/em>. 2021;146:110504.<\/li>\n<li>de Vos LC, et al. Skin autofluorescence is associated with 5-year mortality and cardiovascular events in patients with peripheral artery disease. <em>Arterioscler Thromb Vasc Biol<\/em>. 2014;34(4):933-938.<\/li>\n<li>Lutgers HL, et al. Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population. <em>Diabetologia<\/em>. 2018.<\/li>\n<li>Meerwaldt R, et al. Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. <em>Diabetologia<\/em>. 2004.<\/li>\n<li>Pilleron S, et al. Accumulation of advanced glycation end products evaluated by skin autofluorescence and incident frailty in older adults from the Bordeaux Three-City cohort. <em>PLoS One<\/em>. 2017;12(10):e0186087.<\/li>\n<li>Isami F, et al. Association of advanced glycation end products, evaluated by skin autofluorescence, with lifestyle habits in a general Japanese population. <em>J Diabetes Investig<\/em>. 2018.<\/li>\n<li>Uribarri J, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. <em>J Am Diet Assoc<\/em>. 2010;110(6):911-916.e12.<\/li>\n<li>\u65e5\u672c\u7cd6\u5c3f\u75c5\u5b66\u4f1a. <em>\u7cd6\u5c3f\u75c5\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32024<\/em>. \u7b2c5\u7ae0 \u8840\u7cd6\u964d\u4e0b\u85ac\u306b\u3088\u308b\u6cbb\u7642.<\/li>\n<li>\u65e5\u672c\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u30d5\u30ec\u30a4\u30eb\u5b66\u4f1a, \u307b\u304b. <em>\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u30d5\u30ec\u30a4\u30eb\u306b\u95a2\u3059\u308b\u6804\u990a\u7ba1\u7406\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32025<\/em>. \u5357\u6c5f\u5802.<\/li>\n<li>\u5c71\u5cb8\u660c\u4e00. \u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u76ae\u819a\u81ea\u5bb6\u86cd\u5149\u5024\u6e2c\u5b9a\u306e\u81e8\u5e8a\u7684\u610f\u7fa9. <em>Diabetes Frontier Online<\/em>.<\/li>\n<li>\u65e5\u672c\u5185\u79d1\u5b66\u4f1a\u96d1\u8a8c. \u8a8d\u77e5\u75c7\u3068\u30b5\u30eb\u30b3\u30da\u30cb\u30a2\u30fb\u30d5\u30ec\u30a4\u30eb. 2018;107(9):1702.<\/li>\n<\/ol>\n<hr \/>\n<p><!-- ===== \u30af\u30ea\u30cb\u30c3\u30af\u7d39\u4ecb\u30d5\u30c3\u30bf\u30fc ===== --><\/p>\n<div style=\"border:1px solid #80cbc4; border-radius:12px; overflow:hidden; margin:32px 0;\">\n<div style=\"background:#004d40; padding:18px 24px;\">\n<div style=\"color:#80cbc4; font-size:0.85em; letter-spacing:2px; margin-bottom:4px;\">GORYOKAI GROUP<\/div>\n<div style=\"color:#ffffff; font-size:1.5em; font-weight:bold; line-height:1.3;\">\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662<\/div>\n<\/p><\/div>\n<div style=\"background:#ffffff; padding:24px;\">\n<table style=\"width:100%; border-collapse:separate; border-spacing:4px; margin-bottom:18px;\">\n<tr>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u5185\u79d1<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u5c0f\u5150\u79d1<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u7cd6\u5c3f\u75c5\u5185\u79d1<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u4ee3\u8b1d\u5185\u79d1<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u30a2\u30ec\u30eb\u30ae\u30fc\u79d1<\/td>\n<\/tr>\n<tr>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u76ae\u819a\u79d1<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u751f\u6d3b\u7fd2\u6163\u75c5<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u8a2a\u554f\u8a3a\u7642<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u5fc3\u7642\u5185\u79d1<\/td>\n<td style=\"background:#00796b; color:#fff; padding:8px 10px; border-radius:20px; text-align:center; font-size:0.9em; font-weight:bold;\">\u5065\u5eb7\u8a3a\u65ad<\/td>\n<\/tr>\n<\/table>\n<p style=\"margin:12px 0 4px 0; line-height:1.6;\">\u3012145-0072 \u6771\u4eac\u90fd\u5927\u7530\u533a\u7530\u5712\u8abf\u5e03\u672c\u753a40-12 \u30b3\u30f3\u30c9\u7530\u5712\u8abf\u5e03\uff12\u968e<\/p>\n<p style=\"margin:0 0 12px 0; color:#00796b; font-weight:bold;\">\u6771\u6025\u6771\u6a2a\u7dda\u30fb\u76ee\u9ed2\u7dda\u3000\u591a\u6469\u5ddd\u99c5 \u5f92\u6b695\u5206<\/p>\n<div style=\"display:inline-block; background:#00796b; color:#fff; padding:6px 14px; border-radius:4px; font-size:0.9em; font-weight:bold; margin:8px 0 16px 0;\">\u571f\u66dc\u5348\u524d\u3082\u8a3a\u7642<\/div>\n<table style=\"width:100%; border-collapse:collapse; margin-bottom:18px; font-size:0.92em;\">\n<thead>\n<tr style=\"background:#004d40; color:#fff;\">\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u8a3a\u7642\u6642\u9593<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u6708<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u706b<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u6c34<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u6728<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u91d1<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u571f<\/th>\n<th style=\"padding:8px 4px; border:1px solid #004d40; text-align:center;\">\u65e5\u795d<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; background:#f1f8f6;\">\u5348\u524d<br \/>9:00-12:00<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#bbb; font-size:1.3em;\">\u4f11<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; background:#f1f8f6;\">\u5348\u5f8c<br \/>15:30-19:00<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#00796b; font-weight:bold; font-size:1.3em;\">\u25cb<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#bbb; font-size:1.3em;\">\u4f11<\/td>\n<td style=\"padding:8px 4px; border:1px solid #b2dfdb; text-align:center; color:#bbb; font-size:1.3em;\">\u4f11<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"width:100%; border-collapse:separate; border-spacing:8px 0;\">\n<tr>\n<td style=\"width:25%;\">\n          <a href=\"https:\/\/clinics-app.com\/clinic\/5e01b71c9e974d40c8a4c361\/reservation?method=visit\" style=\"display:block; background:#ffffff; border:2px solid #E53935; border-radius:8px; padding:14px 6px; text-align:center; text-decoration:none; color:#E53935; font-weight:bold;\"><br \/>\n            <img decoding=\"async\" src=\"https:\/\/www.medley.jp\/assets\/img\/logo\/clinics.svg\" alt=\"CLINICS\" style=\"height:28px; display:block; margin:0 auto 6px;\"><br \/>\n            <span style=\"display:block; font-size:1.05em;\">WEB\u4e88\u7d04<\/span><br \/>\n          <\/a>\n        <\/td>\n<td style=\"width:25%;\">\n          <a href=\"https:\/\/clinics-questionnaire.medley.life\/clinic\/639022194dc5ab531c90e7e8\" style=\"display:block; background:#ffffff; border:2px solid #E53935; border-radius:8px; padding:14px 6px; text-align:center; text-decoration:none; color:#E53935; font-weight:bold;\"><br \/>\n            <img decoding=\"async\" src=\"https:\/\/www.medley.jp\/assets\/img\/logo\/melmo.svg\" alt=\"melmo\" style=\"height:28px; display:block; margin:0 auto 6px;\"><br \/>\n            <span style=\"display:block; font-size:1.05em;\">WEB\u554f\u8a3a<\/span><br \/>\n          <\/a>\n        <\/td>\n<td style=\"width:25%;\">\n          <a href=\"https:\/\/lin.ee\/lvrd7tl\" style=\"display:block; background:#06C755; border:2px solid #06C755; border-radius:8px; padding:14px 6px; text-align:center; text-decoration:none; color:#fff; font-weight:bold;\"><br \/>\n            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"28\" height=\"28\" viewBox=\"0 0 24 24\" fill=\"#fff\" style=\"display:block; margin:0 auto 6px;\"><path d=\"M19.365 9.863c.349 0 .63.285.63.631 0 .345-.281.63-.63.63H17.61v1.125h1.755c.349 0 .63.283.63.63 0 .344-.281.629-.63.629h-2.386c-.345 0-.627-.285-.627-.629V8.108c0-.345.282-.63.63-.63h2.386c.346 0 .627.285.627.63 0 .349-.281.63-.63.63H17.61v1.125h1.755zm-3.855 3.016c0 .27-.174.51-.432.596-.064.021-.133.031-.199.031-.211 0-.391-.09-.51-.25l-2.443-3.317v2.94c0 .344-.279.629-.631.629-.346 0-.626-.285-.626-.629V8.108c0-.27.173-.51.43-.595.06-.023.136-.033.194-.033.195 0 .375.104.495.254l2.462 3.33V8.108c0-.345.282-.63.63-.63.345 0 .63.285.63.63v4.771zm-5.741 0c0 .344-.282.629-.631.629-.345 0-.627-.285-.627-.629V8.108c0-.345.282-.63.63-.63.346 0 .628.285.628.63v4.771zm-2.466.629H4.917c-.345 0-.63-.285-.63-.629V8.108c0-.345.285-.63.63-.63.348 0 .63.285.63.63v4.141h1.756c.348 0 .629.283.629.63 0 .344-.282.629-.629.629M24 10.314C24 4.943 18.615.572 12 .572S0 4.943 0 10.314c0 4.811 4.27 8.842 10.035 9.608.391.082.923.258 1.058.59.12.301.079.766.038 1.08l-.164 1.02c-.045.301-.24 1.186 1.049.645 1.291-.539 6.916-4.078 9.436-6.975C23.176 14.393 24 12.458 24 10.314\"\/><\/svg><br \/>\n            <span style=\"display:block; font-size:1.05em; color:#fff;\">LINE<\/span><br \/>\n          <\/a>\n        <\/td>\n<td style=\"width:25%;\">\n          <a href=\"tel:0337215222\" style=\"display:block; background:#D84315; border:2px solid #D84315; border-radius:8px; padding:14px 6px; text-align:center; text-decoration:none; color:#fff; font-weight:bold;\"><br \/>\n            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"28\" height=\"28\" viewBox=\"0 0 24 24\" fill=\"#fff\" style=\"display:block; margin:0 auto 6px;\"><path d=\"M20.01 15.38c-1.23 0-2.42-.2-3.53-.56-.35-.12-.74-.03-1.01.24l-1.57 1.97c-2.83-1.35-5.48-3.9-6.89-6.83l1.95-1.66c.27-.28.35-.67.24-1.02-.37-1.11-.56-2.3-.56-3.53 0-.54-.45-.99-.99-.99H4.19C3.65 3 3 3.24 3 3.99 3 13.28 10.73 21 20.01 21c.71 0 .99-.63.99-1.18v-3.45c0-.54-.45-.99-.99-.99z\"\/><\/svg><br \/>\n            <span style=\"display:block; font-size:1.05em; color:#fff;\">TEL<\/span><br \/>\n          <\/a>\n        <\/td>\n<\/tr>\n<\/table><\/div>\n<\/div>\n<p style=\"text-align:right; font-size:0.9em; color:#555; margin-top:14px;\">\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u3000\u4e94\u85e4 \u826f\u5c06<br \/><span style=\"font-size:0.88em;\">\u65e5\u672c\u6297\u52a0\u9f62\u533b\u5b66\u4f1a\u5c02\u9580\u533b\u30fb\u65e5\u672c\u7cd6\u5c3f\u75c5\u5354\u4f1a\u767b\u9332\u533b\u30fb\u65e5\u672c\u65c5\u884c\u533b\u5b66\u4f1a\u8a8d\u5b9a\u533b<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7686\u3055\u307e\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u306e\u4e94\u85e4\u826f\u5c06\u3067\u3059\u3002 \u300c\u6700\u8fd1\u3001\u304a\u808c\u306e\u304f\u3059\u307f\u3084\u75b2\u308c\u3084\u3059\u3055\u304c\u6c17\u306b\u306a\u308b\u300d\u300c\u7cd6\u5c3f\u75c5\u3060\u3068\u8a00\u308f\u308c\u3066\u3001\u5408\u4f75\u75c7\u304c\u5fc3\u914d\u300d\u300c\u4e21\u89aa\u304c\u8a8d\u77e5\u75c7\u3084\u9aa8\u7c97\u9b06\u75c7\u3067\u3001\u81ea\u5206\u306e\u8001\u5316\u3082\u6c17\u306b\u306a\u308a\u59cb\u3081\u305f\u300d\u2014\u2014\u3053\u3046\u3057\u305f\u304a\u60a9\u307f\u306b\u5171&#8230;<\/p>\n","protected":false},"author":2,"featured_media":2156,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,459,566,814,103,14,12,23,15],"tags":[504,505,245,244,18,35,246,506,507,422],"class_list":["post-2137","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-takeuchi-internal-medicine-and-pediatrics","category-459","category-566","category-814","category-103","category-14","category-12","category-23","category-15","tag-age","tag-505","tag-245","tag-244","tag-18","tag-35","tag-246","tag-506","tag-507","tag-422","wpcat-1-id","wpcat-459-id","wpcat-566-id","wpcat-814-id","wpcat-103-id","wpcat-14-id","wpcat-12-id","wpcat-23-id","wpcat-15-id"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\" \/>\n\t<meta name=\"robots\" content=\"max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n\t<meta name=\"author\" content=\"\u4e94\u85e4 \u826f\u5c06\"\/>\n\t<meta name=\"keywords\" content=\"age\uff53,\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb,\u5185\u79d1,\u591a\u6469\u5ddd,\u5c0f\u5150\u79d1,\u7530\u5712\u8abf\u5e03,\u76ae\u819a\u79d1,\u7cd6\u5316\u7523\u7269,\u7cd6\u8cea,\u7f8e\u5bb9\u76ae\u819a\u79d1\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\n\t\t<script async src=\"https:\/\/www.googletagmanager.com\/gtag\/js?id=G-NMTPHD6S5N\"><\/script>\n<script>\nwindow.dataLayer = window.dataLayer || [];\nfunction gtag(){dataLayer.push(arguments);}\ngtag('js', new Date());\n\ngtag('config', 'G-NMTPHD6S5N');\ngtag('config', 'G-SEDLT798VX');\n<\/script>\n<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':\nnew Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],\nj=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src=\n'https:\/\/www.googletagmanager.com\/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);\n})(window,document,'script','dataLayer','GTM-54V36QRR');<\/script>\n<script async src=\"https:\/\/www.googletagmanager.com\/gtag\/js?id=UA-9162760-67\"><\/script>\n<script>\n window.dataLayer = window.dataLayer || [];\n function gtag(){dataLayer.push(arguments);}\n gtag('js', new Date());\n \n gtag('config', 'UA-143245943-38');\n gtag('config', 'UA-9162760-67');\ngtag('config', 'UA-10175952-2');\n<\/script>\n\t\t<meta property=\"og:locale\" content=\"ja_JP\" \/>\n\t\t<meta property=\"og:site_name\" content=\"\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 |\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\" \/>\n\t\t<meta property=\"og:description\" content=\"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2026-05-10T11:45:00+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2026-05-21T13:41:25+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary\" \/>\n\t\t<meta name=\"twitter:title\" content=\"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662\" \/>\n\t\t<meta name=\"twitter:description\" content=\"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\" \/>\n\t\t<meta name=\"twitter:creator\" content=\"@IinTakeuchi\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#article\",\"name\":\"\\u3010\\u533b\\u5e2b\\u76e3\\u4fee\\u3011AGEs\\uff08\\u7d42\\u672b\\u7cd6\\u5316\\u7523\\u7269\\uff09\\u3068\\u8001\\u5316\\u30fb\\u75c5\\u6c17\\u306e\\u95a2\\u4fc2\\uff5c\\u6700\\u65b0\\u7814\\u7a76\\u30a8\\u30d3\\u30c7\\u30f3\\u30b9\\u3068\\u4f53\\u5185\\u7cd6\\u5316\\u5ea6\\u691c\\u67fb\\u306e\\u3054\\u6848\\u5185 | \\u7af9\\u5185\\u5185\\u79d1\\u5c0f\\u5150\\u79d1\\u533b\\u9662\",\"headline\":\"\\u3010\\u533b\\u5e2b\\u76e3\\u4fee\\u3011AGEs\\uff08\\u7d42\\u672b\\u7cd6\\u5316\\u7523\\u7269\\uff09\\u3068\\u8001\\u5316\\u30fb\\u75c5\\u6c17\\u306e\\u95a2\\u4fc2\\uff5c\\u6700\\u65b0\\u7814\\u7a76\\u30a8\\u30d3\\u30c7\\u30f3\\u30b9\\u3068\\u4f53\\u5185\\u7cd6\\u5316\\u5ea6\\u691c\\u67fb\\u306e\\u3054\\u6848\\u5185\",\"author\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/author\\\/yoshimasa-goto\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/image-33.png\",\"width\":436,\"height\":163},\"datePublished\":\"2026-05-10T20:45:00+09:00\",\"dateModified\":\"2026-05-21T22:41:25+09:00\",\"inLanguage\":\"ja\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#webpage\"},\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#webpage\"},\"articleSection\":\"\\u30af\\u30ea\\u30cb\\u30c3\\u30af, \\u30b5\\u30d7\\u30ea\\u30e1\\u30f3\\u30c8, \\u4e94\\u826f\\u4f1a\\u30af\\u30ea\\u30cb\\u30c3\\u30af, \\u5185\\u670d\\u85ac, \\u6804\\u990a\\u76f8\\u8ac7, \\u7cd6\\u5c3f\\u75c5, \\u81ea\\u8cbb\\u8a3a\\u7642, \\u8a8d\\u77e5\\u75c7, \\u9aa8\\u7c97\\u9b06\\u75c7, AGE\\uff53, \\u4f53\\u5185\\u7cd6\\u5316\\u5ea6\\u691c\\u67fb, \\u5185\\u79d1, \\u591a\\u6469\\u5ddd, \\u5c0f\\u5150\\u79d1, \\u7530\\u5712\\u8abf\\u5e03, \\u76ae\\u819a\\u79d1, \\u7cd6\\u5316\\u7523\\u7269, \\u7cd6\\u8cea, \\u7f8e\\u5bb9\\u76ae\\u819a\\u79d1\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog#listItem\",\"position\":1,\"name\":\"\\u30db\\u30fc\\u30e0\",\"item\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/#listItem\",\"name\":\"\\u81ea\\u8cbb\\u8a3a\\u7642\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/#listItem\",\"position\":2,\"name\":\"\\u81ea\\u8cbb\\u8a3a\\u7642\",\"item\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\\\/#listItem\",\"name\":\"\\u30b5\\u30d7\\u30ea\\u30e1\\u30f3\\u30c8\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog#listItem\",\"name\":\"\\u30db\\u30fc\\u30e0\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\\\/#listItem\",\"position\":3,\"name\":\"\\u30b5\\u30d7\\u30ea\\u30e1\\u30f3\\u30c8\",\"item\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#listItem\",\"name\":\"\\u3010\\u533b\\u5e2b\\u76e3\\u4fee\\u3011AGEs\\uff08\\u7d42\\u672b\\u7cd6\\u5316\\u7523\\u7269\\uff09\\u3068\\u8001\\u5316\\u30fb\\u75c5\\u6c17\\u306e\\u95a2\\u4fc2\\uff5c\\u6700\\u65b0\\u7814\\u7a76\\u30a8\\u30d3\\u30c7\\u30f3\\u30b9\\u3068\\u4f53\\u5185\\u7cd6\\u5316\\u5ea6\\u691c\\u67fb\\u306e\\u3054\\u6848\\u5185\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/#listItem\",\"name\":\"\\u81ea\\u8cbb\\u8a3a\\u7642\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#listItem\",\"position\":4,\"name\":\"\\u3010\\u533b\\u5e2b\\u76e3\\u4fee\\u3011AGEs\\uff08\\u7d42\\u672b\\u7cd6\\u5316\\u7523\\u7269\\uff09\\u3068\\u8001\\u5316\\u30fb\\u75c5\\u6c17\\u306e\\u95a2\\u4fc2\\uff5c\\u6700\\u65b0\\u7814\\u7a76\\u30a8\\u30d3\\u30c7\\u30f3\\u30b9\\u3068\\u4f53\\u5185\\u7cd6\\u5316\\u5ea6\\u691c\\u67fb\\u306e\\u3054\\u6848\\u5185\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/category\\\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\\\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\\\/#listItem\",\"name\":\"\\u30b5\\u30d7\\u30ea\\u30e1\\u30f3\\u30c8\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/#organization\",\"name\":\"\\u7af9\\u5185\\u5185\\u79d1\\u5c0f\\u5150\\u79d1\\u533b\\u9662\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/logo.png\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#organizationLogo\",\"width\":384,\"height\":70},\"image\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#organizationLogo\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/author\\\/yoshimasa-goto\\\/#author\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/author\\\/yoshimasa-goto\\\/\",\"name\":\"\\u4e94\\u85e4 \\u826f\\u5c06\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#authorImage\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/73c40b8ea6534a300f00d213b4a0dc600a88d7166ca3672a375f8dc4b6a94bc2?s=96&d=mm&r=g\",\"width\":96,\"height\":96,\"caption\":\"\\u4e94\\u85e4 \\u826f\\u5c06\"},\"sameAs\":[\"https:\\\/\\\/twitter.com\\\/IinTakeuchi\",\"https:\\\/\\\/www.instagram.com\\\/takeuchi_iin\\\/\",\"https:\\\/\\\/www.youtube.com\\\/@dr.6833\"]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#webpage\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/\",\"name\":\"\\u3010\\u533b\\u5e2b\\u76e3\\u4fee\\u3011AGEs\\uff08\\u7d42\\u672b\\u7cd6\\u5316\\u7523\\u7269\\uff09\\u3068\\u8001\\u5316\\u30fb\\u75c5\\u6c17\\u306e\\u95a2\\u4fc2\\uff5c\\u6700\\u65b0\\u7814\\u7a76\\u30a8\\u30d3\\u30c7\\u30f3\\u30b9\\u3068\\u4f53\\u5185\\u7cd6\\u5316\\u5ea6\\u691c\\u67fb\\u306e\\u3054\\u6848\\u5185 | \\u7af9\\u5185\\u5185\\u79d1\\u5c0f\\u5150\\u79d1\\u533b\\u9662\",\"description\":\"\\u7530\\u5712\\u8abf\\u5e03\\u30fb\\u5927\\u7530\\u533a\\u306e\\u7af9\\u5185\\u5185\\u79d1\\u5c0f\\u5150\\u79d1\\u533b\\u9662 \\u9662\\u9577\\u304c\\u89e3\\u8aac\\u3002AGEs\\uff08\\u7d42\\u672b\\u7cd6\\u5316\\u7523\\u7269\\uff09\\u3068\\u8001\\u5316\\u30fb\\u7cd6\\u5c3f\\u75c5\\u30fb\\u8a8d\\u77e5\\u75c7\\u306e\\u95a2\\u4fc2\\u3092\\u6700\\u65b0\\u30a8\\u30d3\\u30c7\\u30f3\\u30b9\\u3067\\u8a73\\u3057\\u304f\\u8aac\\u660e\\u3002\\u8155\\u3078\\u306e\\u6a5f\\u5668\\u88c5\\u7740\\u3067\\u4f53\\u5185AGEs\\u91cf\\u3092\\u6e2c\\u5b9a\\u3067\\u304d\\u307e\\u3059\\u3002\",\"inLanguage\":\"ja\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#breadcrumblist\"},\"author\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/author\\\/yoshimasa-goto\\\/#author\"},\"creator\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/author\\\/yoshimasa-goto\\\/#author\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/image-33.png\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#mainImage\",\"width\":436,\"height\":163},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\\\/#mainImage\"},\"datePublished\":\"2026-05-10T20:45:00+09:00\",\"dateModified\":\"2026-05-21T22:41:25+09:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/\",\"name\":\"\\u7af9\\u5185\\u5185\\u79d1\\u5c0f\\u5150\\u79d1\\u533b\\u9662\",\"inLanguage\":\"ja\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.takeuchi-iin.jp\\\/blog\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","description":"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002","canonical_url":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/","robots":"max-snippet:-1, max-image-preview:large, max-video-preview:-1","keywords":"age\uff53,\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb,\u5185\u79d1,\u591a\u6469\u5ddd,\u5c0f\u5150\u79d1,\u7530\u5712\u8abf\u5e03,\u76ae\u819a\u79d1,\u7cd6\u5316\u7523\u7269,\u7cd6\u8cea,\u7f8e\u5bb9\u76ae\u819a\u79d1","webmasterTools":{"miscellaneous":"&lt;script async src=\"https:\/\/www.googletagmanager.com\/gtag\/js?id=G-NMTPHD6S5N\"&gt;&lt;\/script&gt;\n&lt;script&gt;\nwindow.dataLayer = window.dataLayer || [];\nfunction gtag(){dataLayer.push(arguments);}\ngtag('js', new Date());\n\ngtag('config', 'G-NMTPHD6S5N');\ngtag('config', 'G-SEDLT798VX');\n&lt;\/script&gt;\n&lt;script&gt;(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':\nnew Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],\nj=d.createElement(s),dl=l!='dataLayer'?'&amp;l='+l:'';j.async=true;j.src=\n'https:\/\/www.googletagmanager.com\/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);\n})(window,document,'script','dataLayer','GTM-54V36QRR');&lt;\/script&gt;\n&lt;script async src=\"https:\/\/www.googletagmanager.com\/gtag\/js?id=UA-9162760-67\"&gt;&lt;\/script&gt;\n&lt;script&gt;\n window.dataLayer = window.dataLayer || [];\n function gtag(){dataLayer.push(arguments);}\n gtag('js', new Date());\n \n gtag('config', 'UA-143245943-38');\n gtag('config', 'UA-9162760-67');\ngtag('config', 'UA-10175952-2');\n&lt;\/script&gt;"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#article","name":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","headline":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185","author":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/author\/yoshimasa-goto\/#author"},"publisher":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/#organization"},"image":{"@type":"ImageObject","url":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-33.png","width":436,"height":163},"datePublished":"2026-05-10T20:45:00+09:00","dateModified":"2026-05-21T22:41:25+09:00","inLanguage":"ja","mainEntityOfPage":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#webpage"},"isPartOf":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#webpage"},"articleSection":"\u30af\u30ea\u30cb\u30c3\u30af, \u30b5\u30d7\u30ea\u30e1\u30f3\u30c8, \u4e94\u826f\u4f1a\u30af\u30ea\u30cb\u30c3\u30af, \u5185\u670d\u85ac, \u6804\u990a\u76f8\u8ac7, \u7cd6\u5c3f\u75c5, \u81ea\u8cbb\u8a3a\u7642, \u8a8d\u77e5\u75c7, \u9aa8\u7c97\u9b06\u75c7, AGE\uff53, \u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb, \u5185\u79d1, \u591a\u6469\u5ddd, \u5c0f\u5150\u79d1, \u7530\u5712\u8abf\u5e03, \u76ae\u819a\u79d1, \u7cd6\u5316\u7523\u7269, \u7cd6\u8cea, \u7f8e\u5bb9\u76ae\u819a\u79d1"},{"@type":"BreadcrumbList","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog#listItem","position":1,"name":"\u30db\u30fc\u30e0","item":"https:\/\/www.takeuchi-iin.jp\/blog","nextItem":{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/#listItem","name":"\u81ea\u8cbb\u8a3a\u7642"}},{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/#listItem","position":2,"name":"\u81ea\u8cbb\u8a3a\u7642","item":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\/#listItem","name":"\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog#listItem","name":"\u30db\u30fc\u30e0"}},{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\/#listItem","position":3,"name":"\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8","item":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#listItem","name":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/#listItem","name":"\u81ea\u8cbb\u8a3a\u7642"}},{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#listItem","position":4,"name":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185","previousItem":{"@type":"ListItem","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\/#listItem","name":"\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8"}}]},{"@type":"Organization","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/#organization","name":"\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","url":"https:\/\/www.takeuchi-iin.jp\/blog\/","logo":{"@type":"ImageObject","url":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#organizationLogo","width":384,"height":70},"image":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#organizationLogo"}},{"@type":"Person","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/author\/yoshimasa-goto\/#author","url":"https:\/\/www.takeuchi-iin.jp\/blog\/author\/yoshimasa-goto\/","name":"\u4e94\u85e4 \u826f\u5c06","image":{"@type":"ImageObject","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#authorImage","url":"https:\/\/secure.gravatar.com\/avatar\/73c40b8ea6534a300f00d213b4a0dc600a88d7166ca3672a375f8dc4b6a94bc2?s=96&d=mm&r=g","width":96,"height":96,"caption":"\u4e94\u85e4 \u826f\u5c06"},"sameAs":["https:\/\/twitter.com\/IinTakeuchi","https:\/\/www.instagram.com\/takeuchi_iin\/","https:\/\/www.youtube.com\/@dr.6833"]},{"@type":"WebPage","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#webpage","url":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/","name":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","description":"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002","inLanguage":"ja","isPartOf":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/#website"},"breadcrumb":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#breadcrumblist"},"author":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/author\/yoshimasa-goto\/#author"},"creator":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/author\/yoshimasa-goto\/#author"},"image":{"@type":"ImageObject","url":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2023\/02\/image-33.png","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#mainImage","width":436,"height":163},"primaryImageOfPage":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/#mainImage"},"datePublished":"2026-05-10T20:45:00+09:00","dateModified":"2026-05-21T22:41:25+09:00"},{"@type":"WebSite","@id":"https:\/\/www.takeuchi-iin.jp\/blog\/#website","url":"https:\/\/www.takeuchi-iin.jp\/blog\/","name":"\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","inLanguage":"ja","publisher":{"@id":"https:\/\/www.takeuchi-iin.jp\/blog\/#organization"}}]},"og:locale":"ja_JP","og:site_name":"\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 |","og:type":"article","og:title":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","og:description":"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002","og:url":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/","og:image":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png","og:image:secure_url":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png","article:published_time":"2026-05-10T11:45:00+00:00","article:modified_time":"2026-05-21T13:41:25+00:00","twitter:card":"summary","twitter:title":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185 | \u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662","twitter:description":"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002","twitter:creator":"@IinTakeuchi","twitter:image":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-content\/uploads\/2019\/10\/logo.png"},"aioseo_meta_data":{"post_id":"2137","title":null,"description":"\u7530\u5712\u8abf\u5e03\u30fb\u5927\u7530\u533a\u306e\u7af9\u5185\u5185\u79d1\u5c0f\u5150\u79d1\u533b\u9662 \u9662\u9577\u304c\u89e3\u8aac\u3002AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u7cd6\u5c3f\u75c5\u30fb\u8a8d\u77e5\u75c7\u306e\u95a2\u4fc2\u3092\u6700\u65b0\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8a73\u3057\u304f\u8aac\u660e\u3002\u8155\u3078\u306e\u6a5f\u5668\u88c5\u7740\u3067\u4f53\u5185AGEs\u91cf\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002","keywords":null,"keyphrases":{"focus":{"keyphrase":"","score":0,"analysis":{"keyphraseInTitle":{"score":0,"maxScore":9,"error":1}}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":{"id":"aioseo-article-63eafb796453e","slug":"article","graphName":"Article","label":"\u8a18\u4e8b","properties":{"type":"BlogPosting","name":"#post_title","headline":"#post_title","description":"#post_excerpt","image":"","keywords":"","author":{"name":"#author_name","url":"#author_url"},"dates":{"include":true,"datePublished":"","dateModified":""}}},"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"Article","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":"{\"article\":{\"articleType\":\"BlogPosting\"},\"course\":{\"name\":\"\",\"description\":\"\",\"provider\":\"\"},\"faq\":{\"pages\":[]},\"product\":{\"reviews\":[]},\"recipe\":{\"ingredients\":[],\"instructions\":[],\"keywords\":[]},\"software\":{\"reviews\":[],\"operatingSystems\":[]},\"webPage\":{\"webPageType\":\"WebPage\"}}","pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":null,"frequency":"default","local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":{"faqs":[],"keyPoints":[],"schemas":[],"titles":[],"descriptions":[],"socialPosts":{"email":[],"linkedin":[],"twitter":[],"facebook":[],"instagram":[]}},"created":"2023-02-07 15:20:50","updated":"2026-05-21 14:29:48","seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\" title=\"\u30db\u30fc\u30e0\">\u30db\u30fc\u30e0<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/\" title=\"\u81ea\u8cbb\u8a3a\u7642\">\u81ea\u8cbb\u8a3a\u7642<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\/\" title=\"\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\">\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"\u30db\u30fc\u30e0","link":"https:\/\/www.takeuchi-iin.jp\/blog"},{"label":"\u81ea\u8cbb\u8a3a\u7642","link":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/"},{"label":"\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8","link":"https:\/\/www.takeuchi-iin.jp\/blog\/category\/%e8%87%aa%e8%b2%bb%e8%a8%ba%e7%99%82\/%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88\/"},{"label":"\u3010\u533b\u5e2b\u76e3\u4fee\u3011AGEs\uff08\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff09\u3068\u8001\u5316\u30fb\u75c5\u6c17\u306e\u95a2\u4fc2\uff5c\u6700\u65b0\u7814\u7a76\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u4f53\u5185\u7cd6\u5316\u5ea6\u691c\u67fb\u306e\u3054\u6848\u5185","link":"https:\/\/www.takeuchi-iin.jp\/blog\/ages%ef%bc%9c%e4%bd%93%e5%86%85%e7%b3%96%e5%8c%96%e5%ba%a6%e6%a4%9c%e6%9f%bb%ef%bc%9e%e3%81%a7%e8%80%81%e5%8c%96%e7%89%a9%e8%b3%aa%e3%81%ae%e8%93%84%e7%a9%8d%e3%82%92%e3%83%81%e3%82%a7%e3%83%83\/"}],"_links":{"self":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts\/2137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/comments?post=2137"}],"version-history":[{"count":18,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts\/2137\/revisions"}],"predecessor-version":[{"id":6998,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/posts\/2137\/revisions\/6998"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/media\/2156"}],"wp:attachment":[{"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/media?parent=2137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/categories?post=2137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.takeuchi-iin.jp\/blog\/wp-json\/wp\/v2\/tags?post=2137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}